Control of Innate Immunity by Memory CD4 T Cells

  • Tara M. Strutt
  • K. Kai McKinstry
  • Susan L. Swain
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 780)


How memory CD4 T cells contribute to protection upon pathogen ­challenge is not fully understood. Beyond traditional helper functions for CD8 T cell and B cell responses, memory CD4 T cells can have a potent impact on the character and a magnitude of inflammatory responses. Here we discuss how memory CD4 T cell control of innate immunity at early time points after pathogen encounters can influence protective responses. We also discuss important aspects of the mechanism whereby memory CD4 T cells directly and indirectly impact the activation status of antigen-presenting cells and production of inflammatory cytokines and chemokines from multiple cell types. We suggest that control of innate immune responses by the adaptive immune system is a powerful protective mechanism associated with the memory state and represents an important fail-safe in the face of pathogens that fail to trigger robust inflammatory responses through conserved pattern recognition receptors.


Antigen Present Cell Innate Immune System Adaptive Immune System Antigen Recognition Mouse Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Businees Media, LLC 2011

Authors and Affiliations

  • Tara M. Strutt
  • K. Kai McKinstry
    • 1
  • Susan L. Swain
  1. 1.Department of PathologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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