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MicroRNAs: Key Components of Immune Regulation

  • Donald T. Gracias
  • Peter D. Katsikis
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 780)

Abstract

The regulation of gene expression at the posttranscriptional level has revealed important control levels for genes important to the immune system. MicroRNAs (miRNAs) are small RNAs that regulate gene expression by inhibiting protein translation or by degrading the mRNA transcript. A single miRNA can potentially regulate the expression of multiple genes and the proteins encoded. MiRNA can influence molecular signaling pathways and regulate many biological processes including immune function. Although the role of miRNAs in development and oncogenesis has been well characterized, their role in the immune system has only begun to emerge. During the past few years, many miRNAs have been found to be important in the development, differentiation, survival, and function of B and T lymphocytes, dendritic cells, macrophages, and other immune cell types. We discuss here recent findings revealing important roles for miRNA in immunity and how miRNAs can regulate innate and adaptive immune responses.

Keywords

Treg Cell Adaptive Immune Response iNKT Cell Innate Immune Cell Monocyte Derive Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Businees Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyDrexel University College of MedicinePhiladelphiaUSA

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