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Influenza Vaccines: What Do We Want and How Can We Get It?

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Crossroads between Innate and Adaptive Immunity III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 780))

Abstract

Influenza vaccines have been in use for more than 60 years and have proven to be efficacious in protecting from influenza infections during epidemics and the recent H1N1 pandemic. The development of influenza vaccines has so far been largely based on empirical grounds, which leaves room for vaccine improvement by implementation of recent insights in innate and adaptive immunity. Also, evaluation and approval of new vaccines rely on rather broad correlates of protection such as the hemagglutination inhibition titre, thereby neglecting qualitative aspects of the immune response. Here we discuss how current inactivated influenza vaccine formulations differ in the type of immune response they elcit, their protective capacity, and what causes these differences. Finally, we will discuss how this knowledge can guide the development of new adjuvants that optimize the protective efficacy of influenza vaccines.

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Acknowledgements

We would like to thank Jan Wilschut, at the University Medical Center Groningen, for helpful comments on the manuscript. F.G. worked under the auspices of the Netherlands Influenza Vaccine Research Centre (NIVAREC), which is financially supported by the Netherlands Organisation for Health Research and Development (ZonMw).

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Authors and Affiliations

  1. Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, 30001, EBC 88, Groningen, NL-9700 RB, The Netherlands

    Anke Huckriede

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  1. Felix Geeraedts
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Correspondence to Anke Huckriede .

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Editors and Affiliations

  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

  2. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  3. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

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Geeraedts, F., Huckriede, A. (2011). Influenza Vaccines: What Do We Want and How Can We Get It?. In: Pulendran, B., Katsikis, P., Schoenberger, S. (eds) Crossroads between Innate and Adaptive Immunity III. Advances in Experimental Medicine and Biology, vol 780. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5632-3_13

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