Biological Detection with Terahertz Spectroscopy

Part of the Integrated Analytical Systems book series (ANASYS)


This chapter describes the basic principles of resolved vibrational spectroscopy of biological macromolecules and species in the sub-terahertz spectral range of radiation and the application of this technology for the biological detection including material in air. The origin of THz spectroscopic signatures specific to bioparticles is based upon low energy internal molecular vibrations that absorb radiation at characteristic frequencies. The multiple resonance features provide distinctive spectral fingerprints for detection and identification of harmful biological species. The sensitivity and selectivity of THz biosensing is demonstrated. The possibility to make THz detector systems for the biological detection is discussed.


Biological Macromolecule Sample Preparation Technique Spectroscopic Signature Absorption Absorption Fourier Transform Spectroscopy 



This work is supported by contracts from the ARO #W911NF-08-C-0049 & #W911NF-10-C-0076 and by the Defense Threat Reduction Agency, grant #HDTRA1-08-1-0038.


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© Springer-Verlag New York 2014

Authors and Affiliations

  1. 1.University of VirginiaCharlottesvilleUSA

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