Modulation of the Interaction of Enteric Bacteria with Intestinal Mucosa by Stress-Related Catecholamines



Stress associated with parturition, transport or mixing has long been correlated with enhanced faecal excretion of diarrhoeal zoonotic pathogens in animals such as Salmonella enterica and Escherichia coli. It may also predispose humans to infection and/or be associated with more severe outcomes. One possible explanation for this phenomenon is the ability of enteric bacterial pathogens to sense and respond to host stress-related catecholamines. This article reviews evidence of the ability of catecholamine hormones to modulate interactions between Gram-negative diarrhoeal pathogens and intestinal mucosa, as well as the molecular mechanisms that may be at work.


Faecal Excretion Virulence Gene Expression Shiga Toxin Ussing Chamber Ileal Loop 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author gratefully acknowledges the support of the Biotechnology and Biological Sciences Research Council U.K. (grant ref. BB/C518022/1).


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Copyright information

© Springer-Verlag New York 2010

Authors and Affiliations

  1. 1.Division of MicrobiologyInstitute for Animal HealthComptonUK

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