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Drug Distribution: Is it a more Important Determinant of Drug Dosing than Clearance?

  • M. Ulldemolins
  • J. A. Roberts
  • J. Rello
Conference paper

Abstract

Appropriate drug dosing in critically ill patients remains an unresolved challenge for clinicians. Severity of disease and aggressive medical management of patients admitted to the intensive care unit (ICU) are known to drive to changes in patient physiology that lead to important variations in pharmacokinetics [1]. However, despite an increasing awareness of differential dosing requirements for critically ill patients, dose-finding studies continue to be performed in healthy volunteers or non-critically ill patients.

Keywords

Continuous Renal Replacement Therapy Antimicrob Agent Drug Distribution Lipophilic Drug Sodium Bromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media Inc. 2010

Authors and Affiliations

  • M. Ulldemolins
    • 1
  • J. A. Roberts
    • 2
  • J. Rello
    • 1
  1. 1.Critical Care DepartmentJoan XXIII University HospitalTarragonaSpain
  2. 2.Burns, Trauma and Critical Care Research Centre, The University of QueenslandRoyal Brisbane and Women's HospitalHerstonAustralia

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