Skip to main content

Renal Dysfunction in Chronic Liver Disease

  • Conference paper
Intensive Care Medicine

Abstract

Acute kidney injury (AKI), chronic kidney disease, and the evaluation of numerous exogenous and endogenous measures of kidney function and injury continue to be the focus of much research in different patient populations. The key reason behind this effort is the well described independent association that small changes in kidney function are strongly linked with increased mortality, extending to those with chronic liver disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Perz JF, Armstrong GL, Farrington LA, Hutin YJF, Bell BP (2006) The contributions of he patitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 45: 529–538

    Article  PubMed  Google Scholar 

  2. Neuschwander-Tetri BA, Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37: 1202–1219

    Article  PubMed  Google Scholar 

  3. Paschos P, Paletas K (2009) Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia 13: 9–19

    CAS  PubMed  Google Scholar 

  4. Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS (2002) NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 36: 1349–1354

    PubMed  Google Scholar 

  5. Bash LD, Astor BC, Coresh J (2010) Risk of incident ESRD: A comprehensive look at cardiovascular risk factors and 17 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis (in press)

    Google Scholar 

  6. Luyckx VA, Brenner BM (2005) Low birth weight, nephron number, and kidney disease. Kidney Int Suppl Aug: S68–77

    Google Scholar 

  7. Sabry AA, Sobh MA, Irving WL, et al (2002) A comprehensive study of the association between hepatitis C virus and glomerulopathy. Nephrol Dial Transpl 17: 239–245

    Article  Google Scholar 

  8. Alavian SM (2009) A shield against a monster: Hepatitis C in hemodialysis patients. World J Gastroenterol 15: 641–646

    Article  PubMed  Google Scholar 

  9. Appel G (2007) Viral infections and the kidney: HIV, hepatitis B, and hepatitis C. Cleve Clin J Med 74: 353–360

    Article  PubMed  Google Scholar 

  10. Ohba S, Kimura K, Mise N, et al (1997) Differential localization of sand e antigens in hepatitis B virus-associated glomerulonephritis. Clin Nephrol 48: 44–47

    CAS  PubMed  Google Scholar 

  11. Russell RT, Pinson CW (2007) Surgical management of polycystic liver disease. World J Gastro 13: 5052–5059

    Google Scholar 

  12. Snanoudj R, Durrbach A, Gauthier E, et al (2004) Changes in renal function in patients with familial amyloid polyneuropathy treated with orthotopic liver transplantation. Nephrol Dial Transpl 19: 1779–1785

    Article  Google Scholar 

  13. Swan SK (1997) The search continues-an ideal marker of GFR. Clin Chem 43: 913–914

    CAS  PubMed  Google Scholar 

  14. Tomlanovich S, Golbetz H, Perlroth M, Stinson E, Myers BD (1986) Limitations of creatinine in quantifying the severity of cyclosporine-induced chronic nephropathy. Am J Kidney Dis 8: 332–337

    CAS  PubMed  Google Scholar 

  15. Takabatake T, Ohta H, Ishida Y, Hara H, Ushiogi Y, Hattori N (1988) Low serum creatinine levels in severe hepatic disease. Arch Intern Med 148: 1313–1315

    Article  CAS  PubMed  Google Scholar 

  16. Slack AJ, Wendon J (2009) The liver and kidney in critically ill patients. Blood Purif 28: 124-134 17. Epstein M (1999) Hepatorenal syndrome. In: Brady HR, Wilcox CS (eds) Therapy in Nephrology and Hypertension — A companion to Brenner and Rector’s The Kidney. WB Saunders, Mayland Heights, pp 45–50

    Google Scholar 

  17. Cholongitas E, Shusang V, Marelli L, et al (2007) Review article: renal function assessment in cirrhosisc — difficulties and alternative measurements. Aliment Pharmacol Ther 26: 969–978

    Article  CAS  PubMed  Google Scholar 

  18. Mehta RL, Kellum JA, Shah SV, et al (2007) Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: R31

    Article  PubMed  Google Scholar 

  19. Kellum JA (2008) Defining and classifying AKI: one set of criteria. Nephrol Dial Transpl 23: 1471–1472

    Article  Google Scholar 

  20. Cruz DN, Ricci Z, Ronco C (2009) Clinical review: RIFLE and AKIN-time for reappraisal. Crit Care 13: 211

    Article  PubMed  Google Scholar 

  21. Senousy BE, Draganov PV (2009) Evaluation and management of patients with refractory ascites. World J Gastro 15: 67–80

    Article  Google Scholar 

  22. Abuelo J (2007) Normotensive ischemic acute renal failure. N Engl J Med 357: 797–805

    Article  CAS  PubMed  Google Scholar 

  23. Mandall MS, Lindenfield J, Tsou M-Y, Zimmerman M (2008) Cardiac evaluation of liver transplant candidates. World J Gastro 12: 3445–3451

    Article  Google Scholar 

  24. Betrosian AP, Agarwal B, Douzinas EE (2007) Acute renal dysfunction in liver diseases. World J Gastro 13: 5552–5559

    CAS  Google Scholar 

  25. Gines P, Martin P-Y, Niederberger M (1997) Prognostic significance of renal dysfunction in cirrhosis. Kidney Int 51 (Suppl): S77–82

    Google Scholar 

  26. Garcia-Tsao G, Parikh CR, Viola A (2008) Acute Kidney Injury in cirrhosis. Hepatology 48: 2064–2077

    Article  CAS  PubMed  Google Scholar 

  27. Sheer TA, Runyon BA (2005) Spontaneous bacterial peritonitis. Dig Dis 23: 39–46

    Article  PubMed  Google Scholar 

  28. Sanyal A, Boyer T, Garcia-Tsao G, et al (2008) A randomized, prospective, double blind placebo-controlled trial of terlipressin for type I hepatorenal syndrome. Gastroenterology 134: 1360–1368

    Article  CAS  PubMed  Google Scholar 

  29. Martin-Lahi M, Pepin M, Guevara M, et al (2008) Terlipressin and albumin vs albumin in patients with cirrhosis and heptorenal syndrome: a randomized study. Gastroenterology 134: 1352–1359

    Article  Google Scholar 

  30. Coca SG, Yalavarthy R, Concato J, Parikh CR (2008) Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review. Kidney Int 73: 1008–1016

    Article  CAS  PubMed  Google Scholar 

  31. Mishra J, Dent C, Tarabishi R, et al (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365: 1231–1238

    Article  CAS  PubMed  Google Scholar 

  32. Herget-Rosenthal S, Marggraf G, Husing J, et al (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66: 1115–1122

    Article  CAS  PubMed  Google Scholar 

  33. Parikh CR, Abraham E, Ancukiewicz M, Edelstein CL (2005) Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol 16: 3046–3052

    Article  CAS  PubMed  Google Scholar 

  34. Han WK, Waikar SS, Johnson A, et al (2008) Urinary biomarkers for detection of acute kidney injury. Kidney Int 73: 863–869

    Article  CAS  PubMed  Google Scholar 

  35. Uchino S, Kellum JA, Bellomo R, et al (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294: 813–818

    Article  CAS  PubMed  Google Scholar 

  36. Niemann CU, Walia A, Waldman J, et al (2009) Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin. Liver Transpl 15: 1852–1860

    Article  PubMed  Google Scholar 

  37. Kidney Disease Outcomes Quality Initiative (2002) Clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39: 51–266

    Google Scholar 

  38. Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16: 31–41

    Article  CAS  PubMed  Google Scholar 

  39. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351: 1296–1305

    Article  CAS  PubMed  Google Scholar 

  40. Bauer C, Melamed ML, Hostetter TH (2008) Staging of Chronic Kidney Disease: Time for a Course Correction. J Am Soc Nephrol 19: 844–846

    Article  PubMed  Google Scholar 

  41. Levey AS, Greene T, Beck GJ, et al (1999) Dietary protein restriction and the progression of chronic renal disease: what have all of the results of the MDRD study shown? Modification of Diet in Renal Disease Study group. J Am Soc Nephrol 10: 2426–2439

    CAS  PubMed  Google Scholar 

  42. Winearls CG, Glassock RJ (2009) Dissecting and refining the staging of chronic kidney disease. Kidney Int 75: 1009–1014

    Article  PubMed  Google Scholar 

  43. Poggio ED, Rule AD (2008) A critical evaluation of chronic kidney disease-should isolated reduced estimated glomerular filtration rate be considered a ‘disease’? Nephrol Dial Transpl 24: 698–700

    Article  Google Scholar 

  44. Skulzacek PA, Szewc RG, Nolan CR, Riley DJ, Lee S, Pergola PE (2003) Prediciton of GFR in liver transplant candidates. Am J Kidney Dis 42: 1169–1176

    Article  Google Scholar 

  45. Proulx NL, Akbari A, Garg AX, Rostom A, Iaffey J, Clark HD (2005) Measured creatinine clearance from timed urine collections substantially overestimates glomerular filtration rate in patients with liver cirrhosis: a systematic review and individual patient meta-analysis. Nephrol Dial Trans 20: 1617–1622

    Article  CAS  Google Scholar 

  46. Woitas RP, Stoffel-Wagner B, Flommersfeld S, et al (2000) Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis. Clin Chem 46: 712–715

    CAS  PubMed  Google Scholar 

  47. Poge U, Gerhardt T, Stoffel-Wagner B, Klehr HU, Sauerbruch T, Woitas RP (2006) Calculation of glomerular filtration rate based on cystatin C in cirrhotic patients. Nephrol Dial Transpl 21: 660–664

    Article  CAS  Google Scholar 

  48. Bolignano D, Coppolino G, Campo S, et al (2008) Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients. Nephrol Dial Transpl 23: 414–416

    Article  CAS  Google Scholar 

  49. Neuberger JM, Gimson A, Davies M, et al (2008) Selection of patients for liver transplantation and allocation of donated livers in the UK. GUT 57: 252–257

    Article  CAS  PubMed  Google Scholar 

  50. Bahirwani R, Reddy KR (2009) Outcomes after liver transplantation: chronic kidney disease. Liver Transpl 15 Suppl 2: S70–74

    Article  PubMed  Google Scholar 

  51. Bahirwani R, Campbell MS, Siropaides T, et al (2008) Transplantation: impact of pretransplant renal insufficiency. Liver Transpl 14: 665–671

    Article  PubMed  Google Scholar 

  52. Ojo AO, Held PI, Port FK, et al (2003) Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 349: 931–940

    Article  CAS  PubMed  Google Scholar 

  53. Neuberger JM, Mamelokb RD, Neuhausc P, et al (2009) Delayed Introduction of Reduced-Dose Tacrolimus, and Renal Function in Liver Transplantation: The ‘ReSpECT’ Study. Am J Transp 9: 327–336

    Article  CAS  Google Scholar 

  54. EBPG Expert Group on Renal Transplantation (2000) European Best Practice Guidelines for Renal Transplantation. Section I: Evaluation, selection and preparation of the potential transplant recipient. Nephrol Dial Transplant 15 (Suppl 7): 3–38

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science + Business Media Inc.

About this paper

Cite this paper

Slack, A., Yeoman, A., Wendon, J. (2010). Renal Dysfunction in Chronic Liver Disease. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5562-3_33

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-5562-3_33

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-5561-6

  • Online ISBN: 978-1-4419-5562-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics