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Update on Antithrombin for the Treatment of Burn Trauma and Smoke Inhalation Injury

  • S. Rehberg
  • D. L. Traber
  • P. Enkhbaatar

Abstract

A severe imbalance of systemic and alveolar hemeostasis, as evidenced by an increase in pro-coagulant and a decrease in anti-fibrinolytic activities, represents a hallmark of burn trauma and smoke inhalation injury [1]. The resulting hypercoagulable state is established within the initial 24 h after the injury and is characterized by high levels of activated factor VII, thrombin-antithrombin complexes, plasminogen activator inhibitor type-1 (PAI-1), and low levels of protein C as well as antithrombin [2]. Plasma levels of antithrombin decrease by 50% in burn patients within the first five days and represent an independent predictor of length of hospital stay and mortality [1, 3]. However, the host response to burn trauma Cl:s well as to smoke inhalation injury, is not only restricted to coagulation disorders, but also includes a marked activation of the inflammation cascade [4]. Both the systemic inflammatory response syndrome (SIRS) and the pro-coagulatory imbalance in hemostasis ultimately result in multiple organ failure (MOF) and increased mortality rates.

Keywords

Acute Lung Injury Tissue Factor Total Body Surface Area Antithrombin Deficiency Smoke Inhalation Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media Inc. 2010

Authors and Affiliations

  • S. Rehberg
    • 1
  • D. L. Traber
    • 1
  • P. Enkhbaatar
    • 1
  1. 1.Investigational Intensive Care Unit Department of AnesthesiologyThe University of Texas Medical BranchGalvestonUSA

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