Weaning Failure of Cardiac Origin: Recent Advances
Mechanical ventilation generally exerts negative hemodynamic effects in patients with normal cardiac function mainly because of the reduction in venous return induced by positive intrathoracic pressure at each insufflation . By contrast, positive pressure ventilation exerts beneficial effects in patients with cardiogenic pulmonary edema such that it is routinely used as a therapy in this category of patients [2, 3]. Conversely, cardiac consequences of spontaneous breathing may be responsible for weaning failure in patients with left heart disease, even though the mechanical ventilation was required for respiratory failure of non-cardiac origin. Since its first description more than twenty years ago , cardiogenic pulmonary edema has been recognized as a frequent cause of weaning failure in patients with underlying left cardiac dysfunction.
KeywordsRight Ventricular Chronic Obstructive Pulmonary Disease Patient Spontaneous Breathing Trial Pulmonary Artery Occlusion Pressure Cardiogenic Pulmonary Edema
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