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The Calcium-Sensing Receptor: Physiology and Pathophysiology

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Diseases of the Parathyroid Glands

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Abstract

The complex control of calcium by the calcium-sensing receptor is the substance of this chapter. It describes the role of this critical receptor at the parathyroid glands and kidneys and focuses on the molecular abnormalities of the receptor and its role in the causation of hypocalcemic and hypercalcemic disorders. It describes how activating and inactivating mutations of the receptor lead to the problems such as familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and other clinical states. It notes the use of genetic analysis of the calcium sensing receptor gene in the diagnosis of these complex problems and provides some therapeutic options for treatment.

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  1. Endocrine Practice, Bruckenstr. 21, Heidelberg, 69120, Germany

    Friedhelm Raue MD

  2. Laboratory of Molecular Genetics, Endocrine Practice, Im Weiher 12, Heidelberg, 61921, Germany

    Christine Haag PhD

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  1. , DEPTS BIOMED ENG & ENDOCRIN-METABOL, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, 44195-5036, Ohio, USA

    Angelo A. Licata

  2. Section of Nephrology, University of Illinois at, Department of Medicine, Associates in Nephrology, SC, Chicago, 60402, Illinois, USA

    Edgar V. Lerma

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Raue, F., Haag, C. (2012). The Calcium-Sensing Receptor: Physiology and Pathophysiology. In: Licata, A., Lerma, E. (eds) Diseases of the Parathyroid Glands. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5550-0_4

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