Abstract
Autism is a complex neurodevelopmental disorder with strong genetic components. Clinically, it is characterized by impairments in verbal and non-verbal communication and social interactions and the presence of stereotypical behaviors. A wide range of sensorimotor problems have been reported in autism, which include abnormalities in manual motor, postural, and oculomotor control. In this review, we focus on oculomotor impairments as a model system for investigating sensorimotor impairments and their cognitive control in this disorder. Basic aspects of sensorimotor control for saccadic and pursuit eye movements are impaired in this population. Development of visual systems that provide input to sensorimotor systems is also affected, and this may contribute to development of atypical visual sensorimotor behaviors. Cognitive mediation of sensorimotor systems is also impaired in autism. Maturation of brain systems that support cognitive control of eye movements appears to reach a developmental plateau earlier, and as a result, individuals with autism do not achieve the same developmental level of ability and performance in adulthood that is observed in typically developing individuals. Development of visual sensorimotor processing and its cognitive control in autism is heterogeneous, suggesting distinct patterns of atypical brain development in this disorder that may have different genetic etiology and clinical implications.
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Abbreviations
- ACC:
-
Anterior cingulate cortex
- CN:
-
Caudate nucleus
- DLPFC:
-
Dorsolateral prefrontal cortex
- FEF:
-
Frontal eye fields
- MRI:
-
Magnetic resonance imaging
- PCC:
-
Posterior cingulate cortex
- PEF:
-
Parietal eye fields
- PPC:
-
Posterior parietal cortex
- SC:
-
Superior colliculus
- SEF:
-
Supplementary eye fields
- SNpr:
-
Substantia nigra pars reticulata
References
Amaral DG, Schumann CM, Nordahl CW. Neuroanatomy of autism. Trends Neurosci. 2008;31:137–45.
Barash S, Melikyan A, Sivakov A, Zhang M, Glickstein M, Thier P. Saccadic dysmetria and adaptation after lesions of the cerebellar cortex. J Neurosci. 1999;19:10931–9.
Cody H, Pelphrey K, Piven J. Structural and functional magnetic resonance imaging of autism. Int J Dev Neurosci. 2002;20:421–38.
Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, Chisum HJ, Moses P, Pierce K, Lord C, Lincoln AJ, Pizzo S, Schreibman L, Haas RH, Akshoomoff NA, Courchesne RY. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology. 2001;57:245–54.
D’Cruz AM, Mosconi MW, Steele S, Rubin LH, Luna B, Minshew N, Sweeney JA. Lateralized response timing deficits in autism. Biol Psychiatry. 2009;66:393–7.
Edin F, Macoveanu J, Olesen P, Tegner J, Klingberg T. Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood. J Cogn Neurosci. 2007;19:750–60.
Goldberg MC, Lasker AG, Zee DS, Garth E, Tien A, Landa RJ. Deficits in the initiation of eye movements in the absence of a visual target in adolescents with high functioning autism. Neuropsychologia. 2002;40:2039–49.
Herbert MR, Ziegler DA, Makris N, Filipek PA, Kemper TL, Normandin JJ, Sanders HA, Kennedy DN, Caviness VS Jr. Localization of white matter volume increase in autism and developmental language disorder. Ann Neurol. 2004;55:530–40.
Johnston K, Everling S. Neurophysiology and neuroanatomy of reflexive and voluntary saccades in non-human primates. Brain Cogn. 2008;68:271–83.
Kawakubo Y, Kasai K, Okazaki S, Hosokawa-Kakurai M, Watanabe K, Kuwabara H, Ishijima M, Yamasue H, Iwanami A, Kato N, Maekawa H. Electrophysiological abnormalities of spatial attention in adults with autism during the gap overlap task. Clin Neurophysiol. 2007;118:1464–71.
Kemner C, van der Geest JN, Verbaten MN, van Engeland H. In search of neurophysiological markers of pervasive developmental disorders: smooth pursuit eye movements? J Neural Transm. 2004;111:1617–26.
Kemper TL, Bauman ML. Neuropathology of infantile autism. Mol Psychiatry. 2002;7 Suppl 2:S12–3.
Klein C, Feige B. An independent components analysis (ICA) approach to the study of developmental differences in the saccadic contingent negative variation. Biol Psychol. 2005;70:105–14.
Klein C, Foerster F, Hartnegg K, Fischer B. Lifespan development of pro- and anti-saccades: multiple regression models for point estimates. Brain Res Dev Brain Res. 2005;160:113–23.
Luna B, Minshew NJ, Garver KE, Lazar NA, Thulborn KR, Eddy WF, Sweeney JA. Neocortical system abnormalities in autism: an fMRI study of spatial working memory. Neurology. 2002;59:834–40.
Luna B, Garver KE, Urban TA, Lazar NA, Sweeney JA. Maturation of cognitive processes from late childhood to adulthood. Child Dev. 2004;75:1357–72.
Luna B, Doll SK, Hegedus SJ, Minshew NJ, Sweeney JA. Maturation of executive function in autism. Biol Psychiatr. 2007;61:474–81.
Luna B, Velanova K, Geier CF. Development of eye-movement control. Brain Cogn. 2008;68:293–308.
McDowell JE, Dyckman KA, Austin BP, Clementz BA. Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans. Brain Cogn. 2008;68:255–70.
Milne E, Swettenham J, Campbell R. Motion perception and autistic spectrum disorder: a review. Curr Psychol Cogn. 2005;23:3–36.
Minshew NJ, Luna B, Sweeney JA. Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology. 1999;52:917–22.
Munoz DP, Armstrong IT, Hampton KA, Moore KD. Altered control of visual fixation and saccadic eye movements in attention-deficit hyperactivity disorder. J Neurophysiol. 2003;90:503–14.
Reilly JL, Harris MS, Kechavan MS, Sweeney JA. Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia. Biol Psychiatr. 2005;57(2):145–54.
Reilly JL, Lencer R, Bishop JR, Keedy S, Sweeney JA. Pharmacological treatment effects on eye movement control. Brain Cogn. 2008;68:415–35.
Rosenhall U, Johansson E, Gillberg C. Oculomotor findings in autistic children. J Laryngol Otol. 1988;102:435–9.
Scharre JE, Creedon MP. Assessment of visual function in autistic children. Optom Vis Sci. 1992;69:433–9.
Scherf KS, Sweeney JA, Luna B. Brain basis of developmental change in visuospatial working memory. J Cogn Neurosci. 2006;18:1045–58.
Sweeney JA, Takarae Y, Macmillan C, Luna B, Minshew NJ. Eye movements in neurodevelopmental disorders. Curr Opin Neurol. (2004);17:37–42.
Takagi M, Zee DS, Tamargo RJ. Effects of lesions of the oculomotor vermis on eye movements in primate: saccades. J Neurophysiol. 1998;80:1911–31.
Takarae Y, Minshew NJ, Luna B, Krisky CM, Sweeney JA. Pursuit eye movement deficits in autism. Brain. 2004a;127:2584–94.
Takarae Y, Minshew NJ, Luna B, Sweeney JA. Oculomotor abnormalities parallel cerebellar histopathology in autism. J Neurol Neurosurg Psychiatry. 2004b;75:1359–61.
Takarae Y, Minshew NJ, Luna B, Sweeney JA. Atypical involvement of frontostriatal systems during sensorimotor control in autism. Psychiatry Res. 2007;156:117–27.
Takarae Y, Luna B, Minshew NJ, Sweeney JA. Patterns of visual sensory and sensorimotor abnormalities in autism vary in relation to history of early language delay. J Int Neuropsychol Soc. 2008;14:980–9.
van der Geest JN, Kemner C, Camfferman G, Verbaten MN, van Engeland H. Eye movements, visual attention, and autism: a saccadic reaction time study using the gap and overlap paradigm. Biol Psychiatr. 2001;50:614–9.
Velanova K, Wheeler ME, Luna B. Maturational changes in anterior cingulate and frontoparietal recruitment support the development of error processing and inhibitory control. Cereb Cortex. 2008;18:2505–22.
Waiter GD, Williams JH, Murray AD, Gilchrist A, Perrett DI, Whiten A. Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: a voxel-based investigation. Neuroimage. 2005;24:455–61.
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Takarae, Y., Luna, B., Sweeney, J.A. (2012). Development of Visual Sensorimotor Systems and Their Cognitive Mediation in Autism. In: Preedy, V. (eds) Handbook of Growth and Growth Monitoring in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1795-9_83
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