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Fertility Preservation pp 29–43Cite as

Ovarian Follicle Development and Fertility Preservation

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Abstract

There are strong incentives to better understand the basic physiology of the mammalian ovary. Functioning ovaries have an enormous impact on the health and well-being of women beyond their role in conception. Further, survivorship after treatment for cancer and other life-threatening illnesses is increasing. Maintaining ovarian function during and after treatment is therefore critical, given the health benefits of functional ovaries and the potential desire to conceive. Basic research efforts have resulted in increased access to human ovary tissue, and a number of key technologies moving into widespread clinical use in less than a decade. In this chapter, we review the basic biology of the ovary and ovarian follicle, including recent data on stem cell support of the organ, and clarify the difference between oocyte and follicle maturation in vivo with the clinical goal of “oocyte maturation.” Breakthroughs will continue to result from the interplay among infertility treatment, efforts to preserve fertility, and advances in our understanding of basic ovarian biology.

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Authors and Affiliations

  1. Department of Animal Sciences, Washington State University, Pullman, WA, USA

    Yuichi Niikura PhD (Research Assistant Professor)

  2. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

    Joshua Johnson PhD (Assistant Professor)

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  1. Yuichi Niikura PhD
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  2. Joshua Johnson PhD
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Correspondence to Joshua Johnson PhD .

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Editors and Affiliations

  1. School of Medicine, Department of Obstetrics, Gynecology, Yale University, Cedar St. 333, New Haven, 06510, Connecticut, USA

    Emre Seli

  2. , Director, Center for Reproductive, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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Niikura, Y., Johnson, J. (2012). Ovarian Follicle Development and Fertility Preservation. In: Seli, E., Agarwal, A. (eds) Fertility Preservation. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1783-6_3

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