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The Senescence Secretome and Its Impact on Tumor Suppression and Cancer

  • Alyssa Kennedy
  • Peter D. Adams
Chapter
Part of the Current Cancer Research book series (CUCR)

Abstract

Cellular senescence is an irreversible proliferation arrest with an emerging physiological role in tumor suppression. For example, primary cells that acquire a first oncogenic event often enter cellular senescence and this serves to block their further neoplastic transformation. Remarkably, the spectrum of factors secreted by senescent cells differs dramatically from their proliferating counterparts. For example, the “secretome” of senescent cells includes increased production of cytokines, matrix metalloproteases, and altered production of many growth factors. This review discusses these factors, their mechanism of regulation in senescent cells, and their contribution to the senescent phenotype and its role in tumor suppression.

Keywords

Tumor Suppression Senescent Cell Replicative Senescence Senescence Program Histone Chaperone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

PDA’s lab is funded by CRUK and the NIH. Thanks to all members of the Adams lab, past and present, for stimulating discussions.

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Fox Chase Cancer CenterPhiladelphiaUK
  2. 2.Cancer Research UK Beatson LabsUniversity of GlasgowGlasgowUK

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