The Senescence Secretome and Its Impact on Tumor Suppression and Cancer
Cellular senescence is an irreversible proliferation arrest with an emerging physiological role in tumor suppression. For example, primary cells that acquire a first oncogenic event often enter cellular senescence and this serves to block their further neoplastic transformation. Remarkably, the spectrum of factors secreted by senescent cells differs dramatically from their proliferating counterparts. For example, the “secretome” of senescent cells includes increased production of cytokines, matrix metalloproteases, and altered production of many growth factors. This review discusses these factors, their mechanism of regulation in senescent cells, and their contribution to the senescent phenotype and its role in tumor suppression.
KeywordsTumor Suppression Senescent Cell Replicative Senescence Senescence Program Histone Chaperone
PDA’s lab is funded by CRUK and the NIH. Thanks to all members of the Adams lab, past and present, for stimulating discussions.
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