Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells
The identification of a rare population of tumour cells capable of transplanting the disease in animal models has radically modified our perception of the biological organization of tumours. These cells, named tumour-initiating cells (TICs), or cancer stem cells (CSCs), share phenotypic and functional characteristics with normal stem cells, most notably their ability to self-renew. Here we discuss regulation of self-renewal in normal haematopoietic and leukaemic stem cells, focusing on the role of cell quiescence and inhibitors of the cell cycle.
KeywordsStem Cell Cancer Stem Cell Acute Myeloid Leukaemia Ataxia Telangiectasia Mutate Normal Stem Cell
We thank Paola Dalton for her scientific editing.
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