Abstract
Dyspepsia, perceived as a very common and sometimes disabling problem, presents a formidable challenge to the clinician and clinical investigator alike. While we all can enumerate a number of symptoms that could be regarded as components of this “syndrome,” many, if not all, are nonspecific in terms of organ of origin or underlying pathophysiology. Overlap with other common symptomatic gastrointestinal disorders, such as functional heartburn and irritable bowel syndrome (IBS), is also an issue; where does dyspepsia end and reflux begin? It is in this context that definitions of dyspepsia, which can guide the clinician in diagnosis and therapy and provide the investigator with coherent study populations, must be developed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Veldhuyzen van Zanten SJ, Flook N, Chiba N, et al. An evidence-based approach to the management of uninvestigated dyspepsia in the era of Helicobacter pylori. Canadian Dyspepsia Working Group. CMAJ. 2000;162 Suppl 12:S3–23.
Halder SLS, Locke 3rd GR, Schleck CD, Zinsmeister AR, Talley NJ. Influence of alcohol consumption on IBS and dyspepsia. Neurogastroenterol Motil. 2006;18:1001–8.
Coppeta L, Pietroiusti A, Magrini A, Somma G, Bergamaschi A. Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust. Scand J Work Environ Health. 2008;34:396–402.
Wildner-Christensen M, Hansen JM, De Muckadell OBS. Risk factors for dyspepsia in a general population: non-steroidal anti-inflammatory drugs, cigarette smoking and unemployment are more important than Helicobacter pylori infection. Scand J Gastroenterol. 2006;41:149–54.
Kulig M, Leodolter A, Vieth M, et al. Quality of life in relation to symptoms in patients with gastro-oesophageal reflux disease: an analysis based on the ProGERD initiative. Aliment Pharmacol Ther. 2003;18:767–76.
Baron JH, Sonnenberg A. Early history of dyspepsia and peptic ulcer in the United States. Am J Gastroenterol. 2009;104:2893–6.
Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut. 1999;45 Suppl 2:II37–42.
Lee SY, Lee KJ, Kim SJ, Cho SW. Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: a population-based study. Digestion. 2009;79:196–201.
Mearin F, Pérez-Oliveras M, Perelló A, et al. Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study. Gastroenterology. 2005;129:98–104.
Kindt S, Tertychnyy A, de Hertogh G, Geboes K, Tack J. Intestinal immune activation in presumed post-infectious functional dyspepsia. Neurogastroenterol Motil. 2009;21:832–e56.
Quigley EMM. Functional dyspepsia (FD) and non-erosive reflux disease (NERD): overlapping or discrete entities? Best Pract Res Clin Gastroenterol. 2004;18:695–706.
Savarino E, Pohl D, Zentilin P, et al. Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. Gut. 2009;58:1185–91.
Galmiche JP, Clouse RE, Bálint A, et al. Functional esophageal disorders. Gastroenterology. 2006;130:1459–65.
Quigley EMM, Keohane J. Dyspepsia. Curr Opin Gastroenterol. 2008;24:692–7.
Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130:1466–79.
Aro P, Talley NJ, Ronkainen J, et al. Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study. Gastroenterology. 2009;137:94–100.
Oshima T, Nakajima S, Yokoyama T, et al. The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia. BMC Med Genet. 2010;11:13.
Hsu Y-C, Liou J-M, Liao S-C, et al. Psychopathology and personality trait in subgroups of functional dyspepsia based on Rome III criteria. Am J Gastroenterol. 2009;104:2534–42.
Quigley EMM. The “con” case. The Rome process and functional gastrointestinal disorders: the barbarians are at the gate! Neurogastroenterol Motil. 2007;19:793–7.
Quigley EMM, Shanahan F. The language of medicine: words as servants and scoundrels. Clin Med. 2009;9:131–5.
Talley NJ, Vakil N, Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005;100:2324–37.
Talley NJ, Vakil NB, Moayyedi P. American gastroenterological association technical review on the evaluation of dyspepsia. Gastroenterology. 2005;129:1756–80.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media LLC
About this chapter
Cite this chapter
Schmidt-Martin, D., Quigley, E.M.M. (2011). The Definition of Dyspepsia. In: Duvnjak, M. (eds) Dyspepsia in Clinical Practice. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1730-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4419-1730-0_1
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-1729-4
Online ISBN: 978-1-4419-1730-0
eBook Packages: MedicineMedicine (R0)