HIV Replication



Knowledge of HIV replication is critical for understanding AIDS pathogenesis and the proper design of therapeutic interventions. HIV–1 replication is a complex, multistep process of virus–host interaction, dependent on both viral and host cell factors. HIV–1 utilizes host cell machinery extensively at each step of viral replication. Transient events that occur during HIV–1 replication include viral fusion, trafficking of the viral nucleoprotein complex in the cytoplasm, reverse transcription, relocation of proviral DNA into the nucleus, integration, transcription, and export of mRNA to the cytoplasm, assembly of new virions at the host cell membrane, budding, and maturation of viral particles (see Fig. 10.1). The proteolytically cleaved HIV proteins are essential for forming infectious virus particles able to start the next round of viral infection.


Preintegration Complex Viral Regulatory Protein Coreceptor Binding Site Host Transcription Factor Viral Nucleoprotein Complex 
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Immunology and Infectious DiseasesHarvard School of Public HealthBostonUSA
  2. 2.Department of Immunology and Infectious DiseasesHarvard School of Public HealthBostonUSA

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