Merkel Cell Carcinoma

  • Steven D. Billings
  • Melissa P. Piliang
Part of the Molecular Pathology Library book series (MPLB, volume 3)


Merkel cells are neural crest-derived cells found in the basal layer of the epidermis and tactile hair discs of Pinkus that serve as mechanoreceptors. Ultrastructurally, they demonstrate neuroendocrine differentiation with membrane-bound dense core neurosecretory granules. Primary neuroendocrine carcinomas of the skin are thought to derive from Merkel cells and have thus been designated Merkel cell carcinoma.


Sentinel Lymph Node Biopsy BRAF Mutation Merkel Cell Carcinoma Negative Sentinel Lymph Node Biopsy Cutaneous Malignancy 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Steven D. Billings
    • 1
  • Melissa P. Piliang
    • 2
  1. 1.Departments of Anatomic Pathology and DermatologyCleveland Clinic FoundationClevelandUSA
  2. 2.Departments of Dermatology and Anatomic PathologyCleveland Clinic FoundationClevelandUSA

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