Oncogenesis in all organ systems is generally considered to be an extremely complex process, with poorly understood etiology and drivers. There is substantial evidence that much of carcinogenesis is driven by changes at the molecular level, at the DNA, RNA, or the protein expression level. New evidence also suggests that alterations in small RNA molecules (microRNA) can contribute to carcinogenesis, though this process is incompletely understood. Finally, environmental, nutritional, and external factors are almost certainly linked to carcinogenesis in some organ systems. It is precisely because of the complexity in all of these widely divergent drivers of carcinogenesis that we continue to search for the causes of cancer in most organ systems.
KeywordsThyroid Cancer Familial Adenomatous Polyposis Short Tandem Repeat Paraffin Embed Tissue Short Tandem Repeat Locus
- 15.Heinrich MC, Owzar K, Corless CL, et al. Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group. J Clin Oncol. 2008;26:5360–5367.CrossRefPubMedGoogle Scholar
- 31.Shakhtarin VV, Tsyb AF, Stepanenko VF, Orlov MY, Kopecky KJ, Davis S. Iodine deficiency, radiation dose, and the risk of thyroid cancer among children and adolescents in the Bryansk region of Russia following the Chernobyl power station accident. Int J Epidemiol. 2003;32:584–591.CrossRefPubMedGoogle Scholar