New Sources in Living Kidney Donation

  • Ruthanne L. Hanto
  • Alvin E. Roth
  • M. Utku Ünver
  • Francis L. Delmonico


The first successful living kidney transplantation occurred in 1954 when Ronald Herrick donated a kidney to his identical twin brother, Richard, at the Peter Bent Brigham Hospital in Boston, Massachusetts. There was no possibility of a rejection of the kidney because the brothers were genetically identical twins. Since then, however, the field of kidney transplantation has evolved so that genetic identity or matching is no longer a necessary criterion for success. Advances in immunosuppressive drugs (and changes in attitudes toward non-directed living donation) currently allow successful kidney transplantation between donors and recipients even with a complete human leukocyte antigen (HLA) mismatch. Despite these advances, the risk of hyperacute rejection has prohibited kidney donation and transplantation between ABO blood type incompatible donors and renal transplant candidates.


Human Leukocyte Antigen Transplant Center Deceased Donor Donor Nephrectomy Human Leukocyte Antigen Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Dr. Kenneth Andreoni, Chair of the OPTN/UNOS Kidney Paired Donation Work Group Committee, and Elizabeth F. Sleeman MHA, UNOS Policy Analyst, for their valuable assistance and insightful comments.


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Copyright information

© Springer-Verlag US 2010

Authors and Affiliations

  • Ruthanne L. Hanto
    • 1
  • Alvin E. Roth
    • 2
  • M. Utku Ünver
    • 3
  • Francis L. Delmonico
    • 4
  1. 1.New England Organ Bank, New England Program for Kidney Exchange, Organ Procurement OrganizationNewtonUSA
  2. 2.Department of EconomicsHarvard Business School, Harvard UniversityBostonUSA
  3. 3.Department of EconomicsBoston CollegeChestnut HillUSA
  4. 4.The Transplantation Society, World Health OrganizationMassachusetts General Hospital Transplant CenterNewtonUSA

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