New Sources in Living Kidney Donation
The first successful living kidney transplantation occurred in 1954 when Ronald Herrick donated a kidney to his identical twin brother, Richard, at the Peter Bent Brigham Hospital in Boston, Massachusetts. There was no possibility of a rejection of the kidney because the brothers were genetically identical twins. Since then, however, the field of kidney transplantation has evolved so that genetic identity or matching is no longer a necessary criterion for success. Advances in immunosuppressive drugs (and changes in attitudes toward non-directed living donation) currently allow successful kidney transplantation between donors and recipients even with a complete human leukocyte antigen (HLA) mismatch. Despite these advances, the risk of hyperacute rejection has prohibited kidney donation and transplantation between ABO blood type incompatible donors and renal transplant candidates.
KeywordsHuman Leukocyte Antigen Transplant Center Deceased Donor Donor Nephrectomy Human Leukocyte Antigen Antigen
We thank Dr. Kenneth Andreoni, Chair of the OPTN/UNOS Kidney Paired Donation Work Group Committee, and Elizabeth F. Sleeman MHA, UNOS Policy Analyst, for their valuable assistance and insightful comments.
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