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Instrumentation in the Cytogenetics Laboratory

Chapter

Abstract

All laboratory procedures were essentially manual at one time. Primitive centrifuges were hand operated, and the earliest microscopes (examples of “new technology” in their own time) utilized operator-positioned mirrors to gather sunlight or candlelight before the discovery of electricity and the invention of the electric light bulb. Today, however, the typical clinical laboratory is dominated by technology, computers, and automated instrumentation. These have improved laboratory practice in three basic ways:
  • Automation of tasks, which can free up technologist time, thereby improving efficiency and reducing costs

  • An increase in the speed, accuracy, and reproducibility at which tasks can be performed

  • Performance of tasks that cannot be accomplished manually

Keywords

Comparative Genomic Hybridization Cytogenetic Laboratory Camera Adapter Electric Light Bulb Automate Imaging System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Special thanks to John Fonte of MetaSystems Group, Inc. for his contribution to the section on automated imaging systems.

References

  1. 1.
    Spurbeck JL, Zinmeister AR, Meyer KJ, Jalal SM. Dynamics of chromosome spreading. Am J Med Genet. 1996;61:387–93.PubMedCrossRefGoogle Scholar
  2. 2.
    Deng W, Tsao SW, Lucas J, Leung CS, Cheung LM. A new method for improving metaphase chromosome spreading. Cytometry A. 2003;51A:46–51.CrossRefGoogle Scholar
  3. 3.
    Public Law 104-191 August 21, 1996. http://www.gpo.gov/fdsys/pkg/PLAW-104publ191/pdf/PLAW-104publ191.pdf . Accessed 19 Oct 2011.
  4. 4.
    Public Law 111-5 February 17, 2009. http://www.gpo.gov/fdsys/pkg/PLAW-111publ5/pdf/PLAW-111publ5.pdf. Accessed 19 Oct 2011.
  5. 5.
    Azofeifa J, Fauth C, Kraus J, Maierhofer C, Langer S, Bolzer A, Reichman J, Schuffenhauer S, Speicher MR. An optimized probe set for the detection of small interchromosomal aberrations by use of 24-color FISH. Am J Hum Genet. 2000;66:1684–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Cytogenetics LaboratoryAmeriPath NortheastSheltonUSA

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