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SuperMEN1 pp 59-67 | Cite as

Role of Menin in Bone Development

  • Hiroshi Kaji
  • Lucie Canaffand
  • Geoffrey N. Hendy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 668)

Abstract

Menin function is related to transcriptional regulation and cell cycle control and it physicallyand functionally interacts with osteotropic transcription factors, such as Smad1/5, Smad3, Runx2 and JunD. Menin promotes the commitment of pluripotent mesenchymal stem cells to the osteoblast lineage, mediated by interactions between menin and the BMP signaling molecules, Smad1/S, or Runx2. On the other hand, in mature osteoblasts the interaction of menin and the TGF-β/Smad3 pathway counteracts the BMP-2/Smad1/S- and Runx2-induced transcriptional activities leading to inhibition of late stage osteoblast differentiation. Moreover, menin suppresses osteoblast maturation partly by inhibiting the differentiation actions of JunD. In conclusion, menin plays an important role in osteoblastogenesis and osteoblast differentiation.

Keywords

Mesenchymal Stem Cell Transform Growth Factor Osteoblast Differentiation Multiple Endocrine Neoplasia Type Osteoblast Lineage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Hiroshi Kaji
    • 1
  • Lucie Canaffand
    • 2
    • 3
  • Geoffrey N. Hendy
    • 4
  1. 1.Division of Diabetes, Metabolism and Endocrinology, Department of Internal MedicineKobe University Graduate School of MedicineKobeJapan
  2. 2.Departments of Medicine Physiology and Human GeneticsMcGill University Royal Victoria HospitalMontrealCanada
  3. 3.Calcium Research Laboratory and Hormones and Cancer Research UnitRoyal Victoria HospitalMontrealCanada
  4. 4.Calcium Research LaboratoryRoyal Victoria HospitalMontrealCanada

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