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Pain After Traumatic Brain Injury

  • Jason K. Ough
  • Devi E. Nampiaparampil
Chapter

Abstract

Traumatic brain injury (TBI) is a significant worldwide public health problem. The annual incidence of TBI in the United States has been cited as 1.7 million cases, but this is likely an underestimate due to underreporting and misdiagnosis, and does not take into account the increasing number of military patients with TBI. It is a contributing factor in nearly one-third of all injury-related deaths in the United States. Total lifetime costs are estimated to be over $60 billion per year. The hallmark features of TBI include head injury with loss of consciousness or alteration of mental status. Consequences of TBI include cognitive deficits, mental health issues, as well as physical pain complaints. Chronic pain is a common complication of TBI and may be exacerbated by psychiatric conditions such as depression and posttraumatic stress disorder. In this chapter, we will emphasize a multidisciplinary approach, incorporating physical, pharmacologic, and psychological modalities for the treatment of pain associated with TBI. Further research into the pathophysiology and diagnosis of TBI and its complications may lead to improved treatments.

Keywords

Traumatic Brain Injury Heterotopic Ossification Severe Traumatic Brain Injury Complex Regional Pain Syndrome Traumatic Brain Injury Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Andary, M. T., Vincent, F., & Esselman, P. C. (1993). Chronic pain following head injury. Physical Medicine and Rehabilitation Clinics, 4(1), 141–150.Google Scholar
  2. Anstey, K. J., Butterworth, P., Jorm, A. F., Christensen, H., Rodgers, B., & Windsor, T. D. (2004). A population survey found an association between self-reports of traumatic brain injury and increased psychiatric symptoms. Journal of Clinical Epidemiology, 57(11), 1202–1209.PubMedCrossRefGoogle Scholar
  3. Barlow, K. M., Thomson, E., Johnson, D., & Minnis, R. A. (2005). Late neurologic and cognitive sequelae of inflicted traumatic brain injury in infancy. Pediatrics, 116, e174–e185.PubMedCrossRefGoogle Scholar
  4. Bazarian, J. J., McClung, J., Shah, M. N., Cheng, Y., Flesher, W., & Kraus, J. (2005). Mild traumatic brain injury in the United States, 1998–2000. Brain Injury, 19, 85–91.PubMedCrossRefGoogle Scholar
  5. Bell, K. R., & Sandell, M. E. (1998). Brain Injury rehabilitation. Post acute rehabilitation and community integration. Archives of Physical Medicine and Rehabilitation, 79, S21–S25.CrossRefGoogle Scholar
  6. Berry, C., Ley, E. J., Mirocha, J., & Salim, A. (2010). Race affects mortality after moderate to severe traumatic brain injury. The Journal of Surgical Research, 163(2), 303–308.PubMedCrossRefGoogle Scholar
  7. Bhullar, I. S., Roberts, E. E., Brown, L., & Lipei, H. (2010). The effect of age on blunt traumatic brain-injured patients. American Surgeon, 76(9), 966–968.PubMedGoogle Scholar
  8. Blyth, B. J., & Bazarian, J. J. (2010). Traumatic alterations in consciousness: Traumatic brain injury. Emergency Medicine Clinics of North America, 28, 571–594.PubMedCrossRefGoogle Scholar
  9. Bohnen, N., & Jolles, J. (1992). Neurobehavioral aspects of post concussive symptoms after mild head injury. The Journal of Nervous and Mental Disease, 180, 183–192.CrossRefGoogle Scholar
  10. Branca, B., & Lake, A. E. (2004). Psychological and neuropsychological integration in multidisciplinary pain management after TBI. The Journal of Head Trauma Rehabilitation, 19(1), 40–57.PubMedCrossRefGoogle Scholar
  11. Bryant, R. A. (2008). Disentangling mild traumatic brain injury and stress reactions. The New England Journal of Medicine, 358(5), 525–527.PubMedCrossRefGoogle Scholar
  12. Bryant, R. A., Marosszeky, J. E., Crooks, J., et al. (1999). Interaction of posttraumatic stress disorder and chronic pain following traumatic brain injury. The Journal of Head Trauma Rehabilitation, 14(6), 588–594.PubMedCrossRefGoogle Scholar
  13. Cassidy, J. D., Carroll, L. J., Peloso, P. M., et al. (2004). Incidence, risk factors and prevention of mild traumatic brain injury: Results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. Journal of Rehabilitation Medicine, 36, 28–60.CrossRefGoogle Scholar
  14. Cernich, A. N., Kurtz, S. M., Mordecai, K. L., & Ryan, P. B. (2010). Cognitive rehabilitation in traumatic brain injury. Current Treatment Options in Neurology, 12(5), 412–423.PubMedCrossRefGoogle Scholar
  15. Collins, M. W., Grindel, S. H., Lovell, M. R., et al. (1999). Relationship between concussion and neuropsychological performance in college football players. The Journal of the American Medical Association, 282, 964–970.CrossRefGoogle Scholar
  16. Corrigan, J. D. (1995). Substance abuse as a mediating factor in outcome from traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 76(4), 302–309.PubMedCrossRefGoogle Scholar
  17. Corrigan, J. D., Selassie, A. W., & Orman, J. A. (2010). The epidemiology of traumatic brain injury. The Journal of Head Trauma Rehabilitation, 25(2), 72–80.PubMedCrossRefGoogle Scholar
  18. Deb, S., Lyons, I., Koutzoukis, C., et al. (1999). Rate of psychiatric illness 1 year after traumatic brain injury. American Journal of Psychiatry, 156(3), 374–378.Google Scholar
  19. DeKosky, S. T., Ikonomovic, M. D., & Gandy, S. (2010). Traumatic brain injury – football, warfare, and long-term effects. The New England Journal of Medicine, 363(14), 1293–1296.PubMedCrossRefGoogle Scholar
  20. DePalma, R. G., Burris, D. G., Champion, H. R., & Hodgson, M. J. (2005). Blast injuries. The New England Journal of Medicine, 352(13), 1335–1342.PubMedCrossRefGoogle Scholar
  21. DeWall, J. (2010). The ABCs of TBI evidence-based guidelines for adult traumatic brain injury care. The Journal of Emergency Medicine Services, 35, 54–61.CrossRefGoogle Scholar
  22. Faul, M., Xu, L., Wald, M. M., & Coronado, V. G. (2010). Traumatic brain injury in the United States: Emergency department visits, hospitalizations and deaths 2002–2006. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control.Google Scholar
  23. Fichtenberg, N. L., Millis, S. R., Mann, N. R., et al. (2000). Factors associated with insomnia among post-acute traumatic brain injury survivors. Brain Injury, 14(7), 659–667.PubMedCrossRefGoogle Scholar
  24. Garland, D. E., Blum, C. E., & Waters, R. L. (1980). Periarticular ossification in head-injured adults. The Journal of Bone and Joint Surgery, 62, 1143–1146.PubMedGoogle Scholar
  25. Gary, K. W., Arango-Lasprilla, J. C., & Stevens, L. F. (2009). Do racial/ethnic differences exist in post-injury outcomes after TBI? A comprehensive review of the literature. Brain Injury, 23(10), 775–789.PubMedCrossRefGoogle Scholar
  26. Gellman, H., Keenan, M. E., & Botte, M. J. (1996). Recognition and management of upper extremity pain syndromes in the patient with brain injury. The Journal of Head Trauma Rehabilitation, 11(4), 23–30.CrossRefGoogle Scholar
  27. Gellman, H., Keenan, M. E., Stone, L., et al. (1992). Reflex sympathetic dystrophy in brain-injured patients. Pain, 51(3), 307–311.PubMedCrossRefGoogle Scholar
  28. Giza, C. C., Mink, R. B., & Madikians, A. (2007). Pediatric traumatic brain injury: Not just little adults. Current Opinion in Critical Care, 13, 143–152.PubMedCrossRefGoogle Scholar
  29. Gomez, P. A., Lobato, R. D., Boto, G. R., et al. (2000). Age and outcome after severe head injury. Acta Neurochir (Wien), 142, 373–381.CrossRefGoogle Scholar
  30. Hallén, M., Karlsson, M., Carlhed, R., et al. (2010). S-100B in serum and urine after traumatic head injury in children. Journal of Trauma, 69(2), 284–289.PubMedCrossRefGoogle Scholar
  31. Herrmann, M., Curio, N., Jost, S., et al. (2001). Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury. Journal of Neurology Neurosurgery Psychiatry, 70(1), 95–100.CrossRefGoogle Scholar
  32. Hoffman, J. M., Pagulayan, K. F., Zawaideh, N., et al. (2007). Understanding pain after traumatic brain injury: Impact on community participation. American Journal of Physical Medicine & Rehabilitation, 86(12), 962–969.CrossRefGoogle Scholar
  33. Hoge, C. W., McGurk, D., Thomas, J. L., et al. (2008). Mild traumatic brain injury in U.S. Soldiers returning from Iraq. The New England Journal of Medicine, 358(5), 453–463.PubMedCrossRefGoogle Scholar
  34. Iezzi, T., Duckworth, M. P., Mercer, V., & Vuong, L. (2007). Chronic pain and head injury following motor vehicle collisions: A double whammy or different sides of a coin. Psychology, Health & Medicine, 12(2), 197–212.CrossRefGoogle Scholar
  35. Ivanhoe, C. B., & Hartman, E. T. (2004). Clinical caveats on medical assessment and treatment of pain after TBI. The Journal of Head Trauma Rehabilitation, 19(1), 29–39.PubMedCrossRefGoogle Scholar
  36. Jennekens, N., de Casterlé, B. D., & Dobbels, F. (2010). A systematic review of care needs of people with traumatic brain injury (TBI) on a cognitive, emotional and behavioural level. Journal of Clinical Nursing, 19(9–10), 1198–1206.PubMedCrossRefGoogle Scholar
  37. Jensen, O. K., & Nielsen, F. F. (1990). The influence of sex and pre-traumatic headache on the incidence and severity of headache after head injury. Cephalalgia, 10, 285–293.PubMedCrossRefGoogle Scholar
  38. Jones, E., Fear, N. T., & Wessely, S. (2007). Shell shock and mild traumatic brain injury: A historical review. American Journal of Psychiatry, 164(11), 1641–1645.PubMedCrossRefGoogle Scholar
  39. Kay, D. W., Kerr, T. A., & Lassman, L. P. (1971). Brain trauma and the postconcussional syndrome. Lancet, 13, 1052–1055.CrossRefGoogle Scholar
  40. Keenan, H. T., Runyan, D. K., & Nocera, M. (2006). Child outcomes and family characteristics 1 year after severe inflicted or noninflicted traumatic brain injury. Pediatrics, 117, 317–324.PubMedCrossRefGoogle Scholar
  41. Kennedy, J. E., Jaffee, M. S., Leskin, G. A., et al. (2007). Posttraumatic stress disorder and posttraumatic stress disorder-like symptoms and mild traumatic brain injury. Journal of Rehabilitation Research and Development, 44(7), 895–919.PubMedCrossRefGoogle Scholar
  42. Khan, F., Baguley, I. J., & Cameron, I. D. (2003). Rehabilitation after traumatic brain injury. The Medical Journal of Australia, 178(6), 290–295.PubMedGoogle Scholar
  43. Koponen, S., Taiminen, T., Portin, R., et al. (2002). Axis I and II psychiatric disorders after traumatic brain injury: A 30-year follow-up study. American Journal of Psychiatry, 159(8), 1315–1321.CrossRefGoogle Scholar
  44. Lahz, S., & Bryant, R. A. (1996). Incidence of chronic pain following traumatic brain injury. Arch Phys Med Rehab, 77(9), 889–891.CrossRefGoogle Scholar
  45. Lane, J. C., & Arciniegas, D. B. (2002). Posttraumatic headache. Current Treatment Options in Neurology, 4(1), 89–104.PubMedCrossRefGoogle Scholar
  46. Langlois, J. A., Kegler, S. R., Butler, J. A., et al. (2003). Traumatic brain injury-related hospital discharges: Results from a 14-state surveillance system, 1997. MMWR Surveillance Summaries, 52(4), 1–20.Google Scholar
  47. Langlois, J. A., Rutland-Brown, W., & Thomas, K. E. (2006). Traumatic brain injury in the United States: Emergency department visits, hospitalizations, and deaths. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control.Google Scholar
  48. Lanzi, G., Balotti, U., Borgatti, R., et al. (1985). Late post-traumatic headache in pediatric age. Cephalalgia, 5, 211–215.PubMedCrossRefGoogle Scholar
  49. Leung, J., Moseley, A., Fereday, S., et al. (2007). The prevalence and characteristics of shoulder pain after traumatic brain injury. Clinical Rehabilitation, 21(2), 171–181.PubMedCrossRefGoogle Scholar
  50. Lingsma, H. F., Roozenbeek, B., Steyerberg, E. W., et al. (2010). Early prognosis in traumatic brain injury: From prophecies to predictions. Lancet Neurology, 9(5), 543–554.PubMedCrossRefGoogle Scholar
  51. Lux, W. E. (2007). A neuropsychiatric perspective on traumatic brain injury. Journal of Rehabilitation Research and Development, 44(7), 951–961.PubMedCrossRefGoogle Scholar
  52. Maas, A. I., Marmarou, A., Murray, G. D., Teasdale, G. M., & Steyerberg, E. W. (2007). Prognosis and clinical trial design in traumatic brain injury: The IMPACT study. Journal of Neurotrauma, 24, 232–238.PubMedCrossRefGoogle Scholar
  53. Masel, B. E., & DeWitt, D. S. (2010). Traumatic brain injury: A disease process, not an event. Journal of Neurotrauma, 27(8), 1529–1540.PubMedCrossRefGoogle Scholar
  54. Matser, E. J., Kessels, A. G., Lezak, M. D., et al. (1999). Neuropsychological impairment in amateur soccer players. The Journal of the American Medical Association, 282, 971–973.CrossRefGoogle Scholar
  55. McKinlay, A., Grace, R. C., Horwood, L. J., Ridder, E. M., MacFarlane, M. R., & Fergusson, D. M. (2008). Prevalence of traumatic brain injury among children, adolescents and young adults: Prospective evidence from a birth cohort. Brain Injury, 22(2), 175–181.PubMedCrossRefGoogle Scholar
  56. McKinlay, A., Grace, R. C., Horwood, L. J., et al. (2009). Adolescent psychiatric symptoms following preschool childhood mild traumatic brain injury: Evidence from a birth cohort. The Journal of Head Trauma Rehabilitation, 24(3), 221–227.PubMedCrossRefGoogle Scholar
  57. Mooney, G., Speed, J., & Sheppard, S. (2005). Factors related to recovery after mild traumatic brain injury. Brain Injury, 19(12), 975–987.PubMedCrossRefGoogle Scholar
  58. Nampiaparampil, D. E. (2008). Prevalence of chronic pain after traumatic brain injury: A systematic review. The Journal of the American Medical Association, 300(6), 711–719.CrossRefGoogle Scholar
  59. National Center for Injury Prevention and Control. (2003). Report to congress on mild traumatic brain injury in the United States: Steps to prevent a serious public health problem. Atlanta: Centers for Disease Control and Prevention.Google Scholar
  60. Necajauskaite, O., Endziniene, M., & Jurieniene, K. (2005). Prevalence, clinical features, and accompanying signs of post-traumatic headache in children. Medicine (Kaunas), 41(2), 100–108.Google Scholar
  61. Okie, S. (2005). Traumatic brain injury in the war zone. The New England Journal of Medicine, 352(20), 2043–2047.PubMedCrossRefGoogle Scholar
  62. Ouellet, M. C., Beaulieu-Bonneau, S., & Morin, C. M. (2006). Insomnia in patients with traumatic brain injury: Frequency, characteristics, and risk factors. The Journal of Head Trauma Rehabilitation, 21(3), 199–212.PubMedCrossRefGoogle Scholar
  63. Overweg-Plandsoen, W. C. G., Kodde, A., van Straaten, M., et al. (1999). Mild closed head injury in children compared to traumatic fractured bone; neurobehavioral sequelae in daily life 2 years after the accident. Neuropediatrics, 158, 249–252.Google Scholar
  64. Redell, J.B., Moore, A.N., Ward, N.H., et al. (2010). Human traumatic brain injury alters plasma microRNA levels. J Neurotraum, 27(12), 2147–56.Google Scholar
  65. Rimel, R. W., Giordani, B., Barth, J. T., Boll, T. J., & Jane, J. A. (1981a). Disability caused by minor head injury. Neurosurgery, 9, 221–228.PubMedCrossRefGoogle Scholar
  66. Rimel, R. W., Giordani, B., Barth, J. T., Boll, T. J., & Jane, J. A. (1981b). Disability caused by minor head injury. Neurosurgery, 9(3), 221–228.PubMedCrossRefGoogle Scholar
  67. Rimel, R. W., Giordani, B., Barth, J. T., & Jane, J. A. (1982). Moderate head injury: Completing the clinical spectrum of brain trauma. Neurosurgery, 11, 344–351.PubMedCrossRefGoogle Scholar
  68. Saatman, K. E., Duhaime, A. C., Bullock, R., et al. (2008). Classification of traumatic brain injury for targeted therapies. Journal of Neurotrauma, 25, 719–738.PubMedCrossRefGoogle Scholar
  69. Schwab, K. A., Warden, D., Lux, W. E., Shupenko, L. A., & Zitnay, G. (2007). Defense and veterans brain injury center: Peacetime and wartime missions. Journal of Rehabilitation Research and Development, 44(7), xiii–xxi.PubMedGoogle Scholar
  70. Selassie, A. W., Pickelsimer, E. E., Frazier, L., Jr., et al. (2004). The effect of insurance status, race, and gender on emergency department disposition of persons with traumatic brain injury. The American Journal of Emergency Medicine, 22, 465–473.PubMedCrossRefGoogle Scholar
  71. Selassie, A. W., Zaloshnja, E., Langlois, J. A., et al. (2008). Incidence of long-term disability following traumatic brain injury hospitalization in the United States. The Journal of Head Trauma Rehabilitation, 23(2), 123–131.PubMedCrossRefGoogle Scholar
  72. Sherman, K. B., Goldberg, M., & Bell, K. R. (2006). Traumatic brain injury and pain. Physical Medicine and Rehabilitation Clinics, 17(2), 473–490.PubMedGoogle Scholar
  73. Silver, J., Kramer, R., Greenwald, S., & Weissman, M. (2001). The association between head injuries and psychiatric disorders: Findings from the New Haven NIMH Epidemiologic Catchment Area Study. Brain Injury, 15(11), 935–945.PubMedCrossRefGoogle Scholar
  74. Smith-Seemiller, L., Fow, N. R., Kant, R., & Franzen, M. D. (2003). Presence of post-concussion syndrome symptoms in patients with chronic pain vs mild traumatic brain injury. Brain Injury, 17(3), 199–206.PubMedCrossRefGoogle Scholar
  75. Sosin, D. M., Sniezek, J. E., & Thurman, D. J. (1996). Incidence of mild and moderate brain injury in the United States, 1991. Brain Injury, 10(1), 47–54.PubMedCrossRefGoogle Scholar
  76. Svetstkova, O., Angerova, Y., Sladkova, P., Bickenbach, J.E., & Raggi, A. (2010). Functioning and disability in traumatic brain injury. Disabil Rehabil, 32, Suppl 1, S68–77.Google Scholar
  77. Tagliaferri, F., Compagnone, C., Korsic, M., & Servadei, F. (2006). A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien), 148, 255–268.CrossRefGoogle Scholar
  78. Thornhill, S., Teasdale, G. M., Murray, G. D., et al. (2000). Disability in young people and adults one year after head injury: Prospective cohort study. British Medical Journal, 320, 1631–1635.PubMedCrossRefGoogle Scholar
  79. Thurman, D. J., Alverson, C., Dunn, K. A., Guerrero, J., & Sniezek, J. E. (1999). Traumatic brain injury in the United States: A public health perspective. The Journal of Head Trauma Rehabilitation, 14, 602–615.PubMedCrossRefGoogle Scholar
  80. Thurman, D. J., Kraus, J. F., & Romer, C. J. (1995a). Standards for surveillance of neurotrauma. Geneva: World Health Organization.Google Scholar
  81. Thurman, D. J., Sniezek, J. E., Johnson, D., et al. (1995b). Guidelines for surveillance of central nervous system injury. Atlanta: Centers for Disease Control and Prevention, US Department of Health and Human Services.Google Scholar
  82. Timonen, M., Miettunen, J., Hakko, H., et al. (2002). The association of preceding traumatic brain injury with mental disorders, alcoholism and criminality: The northern Finland 1966 birth cohort study. Psychiatry Research, 113(3), 217–226.PubMedCrossRefGoogle Scholar
  83. Tyrer, S., & Lievesley, A. (2003). Pain following traumatic brain injury: Assessment and management. Neuropsychological Rehabilitation, 13(1), 189–210.PubMedCrossRefGoogle Scholar
  84. Uomoto, J. M., & Esselman, P. C. (1993). Traumatic brain injury and chronic pain: Differential types and rates by head injury severity. Arch Phys Med Rehab, 74(1), 61–64.Google Scholar
  85. Viguier, D., Dellatolas, G., Gasquet, I., et al. (2001). A psychological assessment of adolescent and young adult inpatients after traumatic brain injury. Brain Injury, 15(3), 263–271.PubMedCrossRefGoogle Scholar
  86. Walker, W. C., Seel, R. T., Curtiss, G., & Warden, D. L. (2005). Headache after moderate and severe traumatic brain injury: A longitudinal analysis. The Archieves of Physical Medicne Rehabiliatation, 86(9), 1793–1800.CrossRefGoogle Scholar
  87. Warden, D. (2006). Military TBI during the Iraq and Afghanistan wars. The Journal of Head Trauma Rehabilitation, 21(5), 398–402.PubMedCrossRefGoogle Scholar
  88. Willemse-van Son, A. H., Ribbers, G. M., Hop, W. C., et al. (2009). Community integration following moderate to severe traumatic brain injury: A longitudinal investigation. Journal of Rehabilitation Medicine, 41, 521–527.PubMedCrossRefGoogle Scholar
  89. Winqvist, S., Jokelainen, J., Luukinen, H., et al. (2006). Adolescents’ drinking habits predict later occurrence of traumatic brain injury: 35-year follow-up of the northern Finland 1966 birth cohort. The Journal of Adolescent Health, 39(2), 275.e1–275.e7.CrossRefGoogle Scholar
  90. Winqvist, S., Jokelainen, J., Luukinen, H., et al. (2007a). Parental alcohol misuse is a powerful predictor for the risk of traumatic brain injury in childhood. Brain Injury, 21(10), 1079–1085.PubMedCrossRefGoogle Scholar
  91. Winqvist, S., Lehtilahti, M., Jokelainen, J., Hillbom, M., & Luukinen, H. (2007b). Traumatic brain injuries in children and young adults: A birth cohort study from northern Finland. Neuroepidemiology, 29(1/2), 136–142.PubMedCrossRefGoogle Scholar
  92. Young, J. A. (2007). Pain and traumatic brain injury. Physical Medicine and Rehabilitation Clinics, 18(1), 145–163.PubMedGoogle Scholar
  93. Zaloshnja, E., Miller, T., Langlois, J. A., & Selassie, A. W. (2008). Prevalence of long-term disability from traumatic brain injury in the civilian population of the United States, 2005. The Journal of Head Trauma Rehabilitation, 23(6), 394–400.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Department of AnesthesiologyNew York University Langone Medical Center, NYU School of MedicineNew YorkUSA
  2. 2.Department of Rehabilitation MedicineNYU School of MedicineNew YorkUSA
  3. 3.Department of Veterans AffairsNew York Harbor Health Care SystemNew YorkUSA

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