Rheumatological Manifestations of Gastrointestinal Disease

  • Nayan K. Kothari
  • Srilatha Kothandaraman


The prevalence of rheumatic symptoms consonant with colopathies of elderly is impressive. Musculoskeletal manifestations are well-recognized complications of gastrointestinal (GI) disorders and many rheumatological diseases also present with GI manifestations. The pathophysiology of rheumatological manifestations may involve increased intestinal permeability in specific GI disorders causing a “leaky gut” situation whereby antigenic material crosses the gut wall and produces antibodies that cross-react with host antigens and exhibit systemic symptoms. The GI disorders such as reactive arthritis, inflammatory bowel disease, various liver disorders, pancreatic carcinoma, celiac disease, Whipple’s disease, jejunoileal bypass arthritis present with a myriad of rheumatological manifestations. Some of them run parallel with the disease while others are independent of the GI disease activity. Diagnosis becomes a challenge in the geriatric population as presentations may be atypical in addition to the coexistence of other musculoskeletal problems.


Inflammatory Bowel Disease Ulcerative Colitis Celiac Disease Familial Mediterranean Fever Primary Sclerosing Cholangitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Nayan K. Kothari
    • 1
  • Srilatha Kothandaraman
    • 1
  1. 1.Department of MedicineSaint Peter’s University Hospital, Drexel University College of MedicineNew BrunswickUSA

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