Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)

  • C. S. Pitchumoni
  • C. S. Pitchumoni
  • C. S. Pitchumoni


Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder in adults worldwide. NAFLD and nonalcoholic steatohepatitis (NASH) represent the hepatic manifestation of “metabolic syndrome.” NAFLD-related cirrhosis is becoming the most common cause of cirrhosis, a cause of primary hepatocellular carcinoma, and rarely intra-hepatic cholangiocarcinoma. The prevalence of NAFLD after age 75 tends to decrease perhaps due to early mortality from comorbid effects of the metabolic syndrome. Most people with NAFLD are asymptomatic. The majority of patients come to the clinician’s attention usually because of abnormal serum aspartate aminotransferase or alanine aminotransferase. A minority of patients progress to NASH, cirrhosis, and even hepatoma. The diagnosis of NAFLD is made clinically, but NASH is a histological term. Presence of inflammatory cells, ballooning degeneration of hepatocytes, Mallory bodies and perivenular collagen deposition. The treatment is with lifestyle modification, weight reduction, and pharmacological agents. In addition to lipid-lowering agents, metformin, vitamins E and C and rosiglitazone, ursodeoxycholic acid, and pentoxifylline are suggested therapies.


Metabolic Syndrome Bariatric Surgery Liver Biopsy Fatty Liver Liver Fibrosis 
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • C. S. Pitchumoni
    • 1
  • C. S. Pitchumoni
    • 2
  • C. S. Pitchumoni
    • 3
  1. 1.Robert Wood Johnson School of Medicine, Drexel University School of MedicinePhiladelphiaUSA
  2. 2.New York Medical CollegeVallhalaUSA
  3. 3.Gastroenterology, Hepatology and NutritionSaint Peter’s University HospitalNew BrunswickUSA

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