Fibromyalgia pp 101-114 | Cite as

Sleep Disturbance

Chapter

Key Chapter Points

  • Sleep disturbance is a frequent co-morbidity in fibromyalgia, with substantial loss of time spent in deeper, restorative stages of sleep.

  • Sleep disturbance lowers the pain threshold and deficiencies in deeper, restorative stages of sleep have been linked to the development of musculoskeletal discomfort and mood disturbances typical of fibromyalgia.

  • Poor sleep also predicts poorer general health.

  • Sleep quality can be reliably measured using an 11-point scale from best (0) to worst possible sleep (10).

  • Sleep improves acutely with benzodiazepine receptor agonists or behavioral interventions, although long-term benefits are superior with behavioral interventions.

  • Several categories of fibromyalgia treatments, including antidepressants and neuromodulating antiepileptics, result in improvements in both pain and sleep.

Keywords

Cardiovascular risk Diabetes Insomnia Obesity Pain threshold Sleep assessment 

References

  1. 1.
    Prinz PN, Bailey SL, Woods DL. Sleep impairments in healthy seniors: roles of stress, cortisol, and interleukin-1 beta. Chronobiol Int. 2000;17:391–404.PubMedCrossRefGoogle Scholar
  2. 2.
    Blackman MR. Age-related alterations in sleep quality and neuroendocrine function. Interrelationships and implications. JAMA. 2000;284:879–81.PubMedCrossRefGoogle Scholar
  3. 3.
    Cajochen C, Münch M, Knoblauch V, Blatter K, Wirz-Justice A. Age-related changes in the circadian and homestatic regulation of human sleep. Chronobiol Int. 2006;23:461–74.PubMedCrossRefGoogle Scholar
  4. 4.
    Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000;284:861–8.PubMedCrossRefGoogle Scholar
  5. 5.
    National Sleep Foundation 2008 Sleep in America Poll. Available at www.sleepfoundation.org. Accessed July 2008.
  6. 6.
    Ohayon MM. Prevalence and correlates of nonrestorative sleep complaints. Arch Intern Med. 2005;165:35–41.PubMedCrossRefGoogle Scholar
  7. 7.
    Steptoe A, Peacey V, Wardle J. Sleep duration and health in young adults. Arch Intern Med. 2006;166:1689–92.PubMedCrossRefGoogle Scholar
  8. 8.
    Pearson NJ, Johnson LL, Nahin RL. Insomnia, trouble sleeping, and complementary and alternative medicine. Analysis of the 2002 National Health Interview Survey. Arch Int Med. 2006;166:1775–82.CrossRefGoogle Scholar
  9. 9.
    Vanitallie TB. Sleep and energy balance: interactive homeostatic systems. Metabolism. 2006;55:S30–5.PubMedCrossRefGoogle Scholar
  10. 10.
    Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol. 2005;99:2008–19.PubMedCrossRefGoogle Scholar
  11. 11.
    Takase B, Akima T, Satomura K, et al. Effects of chronic sleep deprivation on autonomic activity by examining heart rate variability, plasma catecholamine, and intracellular magnesium levels. Biomed Pharmacother. 2004;58:S35–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Bryant PA, Trinder J, Curtis N. Sick and tired: does sleep have a vital role in the immune system? Nat Rev. 2004;4:457–67.Google Scholar
  13. 13.
    Lange T, Dimitriov S, Fehm H, Westermann J, Born J. Shift of monocyte function toward cellular immunity during sleep. Arch Intern Med. 2006;116:1695–700.CrossRefGoogle Scholar
  14. 14.
    Roehrs T, Hyde M, Blaisdell B, Greenwald M, Roth T. Sleep loss and REM sleep loss are hyperalgesic. Sleep. 2006;29:145–51.PubMedGoogle Scholar
  15. 15.
    Prather AA, Marsland AL, Hall M, et al. Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production. Biol Psychol. 2009;82:12–17.PubMedCrossRefGoogle Scholar
  16. 16.
    Mullington JM, Haack M, Toth M, Serrador JM, Meier-Ewert HK. Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation. Prog Cardiovasc Dis. 2009;51:294–302.PubMedCrossRefGoogle Scholar
  17. 17.
    Irwin MR, Carrillo C, Olmstead R. Sleep loss activates cellular markers of inflammation: sex difference. Brain Behav Immun. 2010;24:54–7.PubMedCrossRefGoogle Scholar
  18. 18.
    Gangwisch JE, Heymsfield SB, Boden-Albala B, et al. Short sleep duration as a risk factor for hypertension. Analyses of the first National Health and Nutrition Examination Survey. Hypertension. 2006;47:833–9.PubMedCrossRefGoogle Scholar
  19. 19.
    Ayas NT, White DP, Manson JE, et al. A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med. 2003;163:205–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med. 2006;166:1756–62.PubMedCrossRefGoogle Scholar
  21. 21.
    Gangwisch JE, Malaspina D, Boden-Albala B, Heymsfield SB. Inadequate sleep as a risk factor for obesity: analyses of the NHANES I. Sleep. 2005;28:1289–96.PubMedGoogle Scholar
  22. 22.
    Mallon L, Broman J, Hetta J. High incidence of diabetes in men with sleep complaints or short sleep duration. Diabetes Care. 2005;28:2762–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Yaggi HK, Araujo AB, McKinlay JB. Sleep duration as a risk factor for the development of Type 2 diabetes. Diabetes Care. 2006;29:657–61.PubMedCrossRefGoogle Scholar
  24. 24.
    Knutson KL, Ryden AM, Mander BA, van Cauter E. Role of sleep duration and quality in the risk and severity of Type 2 diabetes mellitus. Arch Intern Med. 2006;166:1768–74.PubMedCrossRefGoogle Scholar
  25. 25.
    Roehrs T, Hyde M, Blaisdell B, Greenwald M, Roth T. Sleep loss and REM sleep loss are hyperalgesic. Sleep. 2006;29:145–51.PubMedGoogle Scholar
  26. 26.
    Roth T. Comorbid insomnia: current directions and future challenges. Am J Manag Care. 2009;15:S6–13.PubMedGoogle Scholar
  27. 27.
    Zoppi M, Maresca M. Symptoms accompanying fibromyalgia. Reumatismo. 2008;60:217–20.PubMedGoogle Scholar
  28. 28.
    Cappelleri JC, Bushmakin AG, McDermott AM, et al. Measurement properties of the Medical Outcomes Study Sleep Scale in patients with fibromyalgia. Sleep Med. 2009;10:766–70.PubMedCrossRefGoogle Scholar
  29. 29.
    Moldofsky H, Scarisbrick P, England R, Smythe H. Musculoskeletal symptoms and non-REM sleep disturbance in patients with “fibrositis syndrome” and healthy subjects. Psychosom Med. 1975;37:341–51.PubMedGoogle Scholar
  30. 30.
    Cappelleri JC, Bushmakin AG, McDermott AM, et al. Psychometric properties of a single-item scale to assess sleep quality among individuals with fibromyalgia. Health Qual Life Outcomes. 2009;7:54.PubMedCrossRefGoogle Scholar
  31. 31.
    Neubauer DN. Current and new thinking in the management of comorbid insomnia. Am J Manag Care. 2009;15:S24–32.PubMedGoogle Scholar
  32. 32.
    Riemann D, Perlis ML. The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies. Sleep Med Rev. 2009;13:205–14.PubMedCrossRefGoogle Scholar
  33. 33.
    Uçeyler N, Häuser W, Sommer C. A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. Arthritis Care Res. 2008;59:1279–98.CrossRefGoogle Scholar
  34. 34.
    Häuser W, Bernardy K, Uçeyler N, Sommer C. Treatment of fibromyalgia syndrome with gabapentin and pregabalin – A meta-analysis of randomized controlled trials. Pain. 2009;145:69–81.PubMedCrossRefGoogle Scholar
  35. 35.
    Russell IJ, Crofford LJ, Leon T, et al. The effects of pregabalin on sleep disturbance symptoms among individuals with fibromyalgia syndrome. Sleep Med. 2009;10:604–10.PubMedCrossRefGoogle Scholar
  36. 36.
    Malanga GA, Gwynn MW, Smith R, Miller D. Tizanidine is effective in the treatment of myofascial pain syndrome. Pain Physician. 2002;5:422–32.PubMedGoogle Scholar
  37. 37.
    Scharf MB, Baumann M, Berkowitz DV. The effects of sodium oxybate on clinical symptoms and sleep patterns in patients with fibromyalgia. J Rheumatol. 2003;30:1070–4.PubMedGoogle Scholar
  38. 38.
    Russell IJ, Perkins AT, Michalek JE. Sodium oxybate relieves pain and improves function in fibromyalgia syndrome: a randomized, double-blind, placebo-controlled, multicenter clinical trial. Arthritis Rheum. 2009;60:299–309.PubMedCrossRefGoogle Scholar
  39. 39.
    Vincent N, Lewycky S. Logging on for better sleep: RCT fo the effectiveness of online treatment for insomnia. Sleep. 2009;32:807–15.PubMedGoogle Scholar
  40. 40.
    Gellis LA, Lichstein KL. Sleep hygiene practices of good and poor sleepers in the United States: an Internet-based study. Behav Ther. 2009;40:1–9.PubMedCrossRefGoogle Scholar
  41. 41.
    Edinger JD, Olsen MK, Stechuchak KM, et al. Cognitive behavioral therapy for patients with primary insomnia or insomnia associated predominantly with mixed psychiatric disorders: a randomized clinical trial. Sleep. 2009;32:499–510.PubMedGoogle Scholar
  42. 42.
    Morin CM, Vallières A, Guay B, et al. Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial. JAMA. 2009;301:2005–15.PubMedCrossRefGoogle Scholar
  43. 43.
    Reiter RJ, Acuna-Castroviejo D, Tan DX. Meatlonin therapy in fibromyalgia. Curr Pain Headache Rep. 2007;11:339–42.PubMedCrossRefGoogle Scholar
  44. 44.
    Yeung WF. Chung KF. Leung YK, Zhang SP. Law AC. Traditional needle acupuncture treatment for insomnia: a systematic review of randomized controlled trials. Sleep Med. 2009;10:694–704.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of PittsburghPittsburghUSA
  2. 2.Division of Arthritis & Rheumatic Diseases (OP09)Oregon Health & Science UniversityPortlandUSA

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