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Inflammation and Adipose Dysfunction

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Abstract

While inflammatory changes in obesity have been recognized for many years, the pathophysiology underlying these alterations is still being elucidated. In fact, the primarycausal mechanisms by which obesity results in activation of immune pathways are not yet fully understood. Some of the prominent theories are explored here.

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Acknowledgments

R.S. is supported by a K12 award from the University of Pennsylvania Clinical and Translational Science Award (UL1RR024134) from the National Center for Research Resources (NCRR). R.S. and M.P.R. receive support from the Diabetes and Endocrine Research Center (P30-DK 019525) at the University of Pennsylvania. M.P.R. is supported by RO1-DK071224 and P50 HL-083799-SCCOR from the National Institutes of Health.

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  1. Cardiovascular Institute and the Institute for Diabetes, Obesity and Metabolism, and the Institute for Translational Medicine and Therapeutics, Departments of Medicine and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Muredach P. Reilly

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  1. Rachana Shah
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Correspondence to Muredach P. Reilly .

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  1. School of Medicine, Div. Endocrinology, Diabetes, &, University of Pennsylvania, Curie Blvd. 415, Philadelphia, 19104, Pennsylvania, USA

    Rexford S. Ahima

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Shah, R., Reilly, M.P. (2011). Inflammation and Adipose Dysfunction. In: Ahima, R. (eds) Metabolic Basis of Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1607-5_9

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