Gastrointestinal Hormones and Obesity

  • Yan Wang
  • Efi Kokkotou


Apart from digesting and absorbing nutrients, the gastrointestinal (GI) tract also possesses important sensing and signaling functions. It is estimated that more than 50 hormones and regulatory peptides are synthesized in the GI, primarily in response to food entering the digestive system [1, 2]. The majority of the bioactive peptides are generated from a larger precursor (pro-hormone) by proteolytic cleavage mediated by various proconvertases (PC), and followed by modifications such as amidation [3]. Gut hormones are secreted from specialized enteroendocrine cells, different types of which are located in the stomach (G-cells), duodenum (D-cells), and the large intestine (L-cells).


Gastric Bypass Anorexia Nervosa Gastric Emptying Ghrelin Level Pancreatic Polypeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Gastroenterology Division, Department of Medicine, Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA

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