Adipokines in Health and Disease

  • Rexford S. Ahima
  • Marcus D. Goncalves


Obesity has become a major public health problem [1]. It is currently estimated that more than 1.6 billion adults worldwide are overweight [body mass index (BMI) >25] and 400 million are obese (BMI >30). The incidence of obesity in children is also very high [1]. The obesity epidemic is attributed mainly to excessive intake of foods rich in fat and sugar, and lack of exercise [1]. Obesity increases the risk of diabetes, hypertension, coronary artery disease, sleep apnea, cancer, and various diseases; therefore, there is enormous interest in understanding the pathogenesis of obesity [1, 2].


Fatty Acid Oxidation Subcutaneous Adipose Tissue Arcuate Nucleus Gastric Inhibitory Polypeptide Induce Insulin Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by grant RO1-DK62348 and PO1-DK49210 from the National Institutes of Health.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and MetabolismUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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