Abstract
The lipid A receptor consists of several subunits. Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14. The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation. TLR4 associates with MD-2, which is required for surface expression and recognition of lipid A. In addition, the RP 10S-MD-1 complex mediates TLR4-mediated response in B cells and negatively regulates TLR4-mediated response in dendritic cells. Thus, lipid A receptor’s function varies among cell populations.
Keywords
- Mouse Peritoneal Macrophage
- Toll Receptor
- Therapy Dendritic Cell
- Human Heat Shock Protein
- Large Polymeric Protein
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2009 Landes Bioscience and Springer Science+Business Media
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Takeda, K. (2009). The Lipid A Receptor. In: Jeannin, JF. (eds) Lipid A in Cancer Therapy. Advances in Experimental Medicine and Biology, vol 667. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1603-7_5
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DOI: https://doi.org/10.1007/978-1-4419-1603-7_5
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