Immunomodulatory Activity and Therapeutic Potential of the Filarial Nematode Secreted Product, ES-62

  • William Harnett
  • Margaret M. Harnett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 666)


ES-62 is a protein that is actively secreted by filarial nematodes during parasitism of the vertebrate host. The molecule is able to direcdy interact with a number of cells of the immune system including B-lymphocytes, dendritic cells, macrophages and mast cells. Interaction appears to be dependent on complexing with TLR4 and results in modulation of the activity of a number of signal transduction molecules including MAP kinases, PI-3 kinase and NF-κB. Immunomodulatory activity of ES-62 appears to be largely due to the presence of phosphorylcholine (PC) moieties covalendy attached to N-type glycans. The net effect of ES-62’s interaction with the immune system is the generation of an antiinflammatory immunological phenotype. As a consequence of this, ES-62 demonstrates striking drug-like activity in models of disease associated with aberrant inflammation, in particular those associated with autoimmunity and allergy.


Mast Cell Sphingosine Kinase Filarial Nematode Airway Hypersensitivity Parasite Immunol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Strathclyde Institute of Pharmacy and Biomedical SciencesUniversity of StrathclydeGlasgowUK
  2. 2.Division of Inflammation Infection and ImmunityUniversity of GlasgowGlasgowUK

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