Lipoxins as an Immune-Escape Mechanism
Here, we discuss the mechanisms of repression of signaling pathways that are triggered by Lipoxin (LX) and are responsible for control of pro-inflammatory response during chronic phase of Toxoplasma gondii infection. We also discuss this mechanism from the perspective of the pathogen, which pirates the host s lipoxygenase machinery to its own advantage as a probable immune-escape mechanism. Pro-inflammatory mediators such as IL-12, IFN-y and TNF are essential in controlling parasite growth during T. gondii infection. However, it is clear that exacerbated production of these cytokines results in host tissue damage. LX, an anti-inflammatory eicosanoid, plays an important role in regulation of immune response to T. gondii.
KeywordsAryl Hydrocarbon Receptor Toxoplasma Gondii Toxoplasma Infection Aryl Hydrocarbon Receptor Nuclear Translocator Host Tissue Damage
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