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FOXL2: At the Crossroads of Female Sex Determination and Ovarian Function

  • Chapter
Forkhead Transcription Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 665))

Abstract

The gene FOXL2 encodes a forkhead transcription factor whose mutations are responsible for the blepharophimosis ptosis epicanthus-inversus syndrome. This genetic disorder is characterized by eyelid and mild craniofacial abnormalities often in association with premature ovarian failure. FOXL2 orthologs are found throughout the animal phylum and its sequence is highly conserved in vertebrates. FOXL2 is one ofthe earliest ovarian markers and it offers,along with its targets, a model to study ovarian development and function. In this chapter, we review recent data concerningits mutations, targets, regulation and functions. Studies ofthe cellular consequences ofFOXL2 mutations seem to indicate that aggregation is a common pathogenic mechanism. However, no reliable genotype/phenotype correlation has been established to predict the exact impact ofpoint mutations in the coding region of FOXL2. FOXL2 has been suggested to be involved in the regulation of cholesterol homeostasis, steroid metabolism, apoptosis, reactive oxygen species detoxification and inflammation processes. Interestingly, all these processes are not equally affected by FOXL2 mutations. The elucidation of the impact of the FOXL2 function in the ovary will allow a better understanding of normal ovarian development and function as well as the pathogenic mechanisms underlying BPES.

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Authors and Affiliations

  1. Institut Jacques Monod, Bâtiment Buffon, 15 rue Hélèna Brion, 75205, Paris Cx 13, France

    Bérénice A. Benayoun, Aurélie Dipietromaria, Claude Bazin & Reiner A. Veitia

  2. Université Paris Diderot-Paris 7, Paris, France

    Bérénice A. Benayoun, Aurélie Dipietromaria, Claude Bazin & Reiner A. Veitia

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  1. Bérénice A. Benayoun
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  2. Aurélie Dipietromaria
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  3. Claude Bazin
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  4. Reiner A. Veitia
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Correspondence to Reiner A. Veitia .

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Editors and Affiliations

  1. Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  2. Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  3. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  4. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  5. Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  6. Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

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Benayoun, B.A., Dipietromaria, A., Bazin, C., Veitia, R.A. (2009). FOXL2: At the Crossroads of Female Sex Determination and Ovarian Function. In: Maiese, K. (eds) Forkhead Transcription Factors. Advances in Experimental Medicine and Biology, vol 665. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1599-3_16

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