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Colorectal Cancer: Adjuvant Therapy

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Abstract

The stage of disease at presentation is the most important predictor of outcome for colon cancer patients. Stage I (T1-2N0M0) disease carries an excellent prognosis of up to 95% 5-year survival rate after resection, and surgical treatment alone is considered sufficient; adjuvant treatment is not indicated.1 Patients with stage II disease (T3-4N0M0) also have excellent 5-year survival, averaging 70–80%, but a subset of high-risk patients have poorer prognosis.1 As such, it has been suggested that some stage II patients may benefit from adjuvant therapy, but the role of treatment in this patient population remains controversial. In contrast, adjuvant treatment repeatedly has been shown to improve survival for stage III (TanyN1-2M0) disease.

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Authors and Affiliations

  1. Roswell Park Cancer Institute and the University of Buffalo, State University of New York, Buffalo, NY, USA

    Kelli Bullard Dunn MD

  2. Department of Surgery, University of Minnesota, St. Paul, MN, USA

    Judith L. Trudel MD, MSc, MHPE, FRCSC, FACS

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  1. Kelli Bullard Dunn MD
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  2. Judith L. Trudel MD, MSc, MHPE, FRCSC, FACS
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Editor information

Editors and Affiliations

  1. Department of Colon and Rectal Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

    David E. Beck MD, FACS, FASCRS

  2. Department of Colorectal Surgery, Lahey Clinic, Tufts University School of Medicine, Burlington, Massachusetts, USA

    Patricia L. Roberts MD, FACS, FASCRS

  3. Section of Colon and Rectal Surgery, Rush Medical Center, Chicago, Illinois, USA

    Theodore J. Saclarides MD, FACS, FASCRS

  4. Department of Surgery, Spectrum Health, Grand Rapids, Michigan, USA

    Anthony J. Senagore MD, FACS, FASCRS

  5. Department of Surgery, UCI Medical Center, Orange, California, USA

    Michael J. Stamos MD, FACS, FASCRS

  6. Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida, USA

    Steven D. Wexner MD, FACS, FASCRS, FRCS, FRCS(Ed)

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© 2011 ASCRS (American Society of Colon and Rectal Surgeons)

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Dunn, K.B., Trudel, J.L. (2011). Colorectal Cancer: Adjuvant Therapy. In: Beck, D.E., Roberts, P.L., Saclarides, T.J., Senagore, A.J., Stamos, M.J., Wexner, S.D. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1584-9_46

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