Integrative Control of Carbon, Nitrogen, Hydrogen, and Sulfur Metabolism: The Central Role of the Calvin–Benson–Bassham Cycle

  • Rick Laguna
  • Gauri S. Joshi
  • Andrew W. Dangel
  • Amanda K. Luther
  • F. Robert Tabita
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 675)


Nonsulfur purple (NSP) photosynthetic bacteria use the Calvin–Benson– Bassham (CBB) reductive pentose phosphate pathway for the reduction of CO2 via ribulose 1,5-bisphosphate (RuBP) carboxylase–oxygenase (RubisCO), as a means to build cell mass during chemoautotrophic or photoautotrophic conditions. In addition, the CBB pathway plays an important role in maintaining redox balance during photoheterotrophic growth conditions. In this communication we describe protein– protein interactions between two transcriptional regulators CbbR and RegA and the possible role of the CbbX protein in regulating the CBB pathway in Rhodobacter sphaeroides. In Rhodopseudomonas palustris, the CbbR and the CbbRRS system (a three-protein, two-component regulatory system) regulate the CBB pathway. Moreover, derepression of the nitrogenase complex, and the production of hydrogen gas, appears to be a common mechanism to balance the redox potential in RubisCO-compromised strains of NSP photosynthetic bacteria.


Rhodobacter Sphaeroides Rhodopseudomonas Palustris Photoautotrophic Growth Photoheterotrophic Growth Phosphoglycolate Phosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by grants DE-FG02-07ER64489 and DE-FG02- DE-FG02-08ER15976 from the Office of Biological and Environmental Research (Genomics: GTL Program) and the Chemical Sciences, Geosciences, and Biosciences Division of the Office of Basic Energy Sciences, respectively, of the US Department of Energy


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Rick Laguna
    • 1
  • Gauri S. Joshi
    • 1
  • Andrew W. Dangel
    • 1
  • Amanda K. Luther
    • 1
  • F. Robert Tabita
    • 1
  1. 1.Department of MicrobiologyThe Ohio State UniversityColumbusUSA

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