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Menopause

  • Tonita Wroolie
  • Megan Holcomb
Chapter

Abstract

Menopause transition is an experience all women undergo either naturally or surgically. This chapter defines the stages of menopause including mental health conditions that have been studied in various populations during these life transition periods. Symptomatology including hot flashes, night sweats, insomnia, and psychiatric symptoms is outlined and examined. Theories about the relationship between menopause and depression such as hormonal fluctuations, psychosocial, and neurobiological factors are discussed along with evidence for and against such theories. Use of hormone/estrogen therapy and its effect on depression in perimenopausal and postmenopausal women is also discussed in this chapter. Surgical versus natural menopause is outlined with evidence suggesting many factors interplay with regard to depression and surgical menopause. Implications for treatment of various psychiatric disorders including anxiety, bipolar disorder, and schizophrenia are discussed. Finally, evidence is presented that shows an increase in sexual dysfunction during menopause transition due to multiple factors including no partner, depressed mood, or living with a child. Treatment implications are included to guide care providers working with women who are undergoing this stage of life change.

Keywords

Depressive Symptom Bipolar Disorder Sexual Dysfunction Sexual Functioning Night Sweat 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Alexander, J. L., Dennerstein, L., Woods, N. F., McEwen, B. S., Halbreich, U., Kotz, K., et al. (2007). Role of stressful life events and menopausal stage in wellbeing and health. Expert Review of Neurotherapies, 7(Suppl. 11), 93–113.Google Scholar
  2. Almeida, O. P., Lautenschlager, N., Vasikaram, S., Leedman, P., & Flicker, L. (2005). Association between physiological serum concentration of estrogen and the mental health of community-dwelling postmenopausal women age 70 years and over. American Journal of Geriatric Psychiatry, 13(2), 142–149.Google Scholar
  3. Aloysi, A., Van Dyk, K., & Sano, M. (2006). Women’s cognitive and affective health and neuropsychiatry. Mount Sinai Journal of Medicine, 73(7), 967–975.PubMedGoogle Scholar
  4. Amore, M., Di Donato, P., Papalini, A., Berti, A., Palareti, A., Ferrari, G., et al. (2004). Psychological status at the menopausal transition: An Italian epidemiological study. Maturitas, 48(2), 115–124.PubMedGoogle Scholar
  5. Amsterdam, J., Garcia-España, F., Fawcett, J., Quitkin, F., Reimherr, F., Rosenbaum, J., et al. (1999). Fluoxetine efficacy in menopausal women with and without estrogen replacement. Journal of Affective Disorders, 55, 11–17.PubMedGoogle Scholar
  6. Avis, N. E., Brambilla, D., McKinlay, S. M., & Vass, K. (1994). A longitudinal analysis of the association between menopause and depression: Results from the Massachusetts Women’s Health Study. Annals of Epidemiology, 4(3), 214–220.PubMedGoogle Scholar
  7. Avis, N. E., Crawford, S., Stellato, R., & Longcope, C. (2001). Longitudinal study of hormone levels and depression among women transitioning through menopause. Climacteric, 4(3), 243–249.PubMedGoogle Scholar
  8. Avis, N. E., Kaufert, P. A., Lock, M., McKinlay, S. M., & Vass, K. (1993). The evolution of menopausal symptoms. Baillieres Clinical Endocrinology and Metabolism, 7(1), 17–32.Google Scholar
  9. Avis, N. E., & McKinlay, S. M. (1991). A longitudinal analysis of women’s attitudes toward the menopause: Results from the Massachusetts Women’s Health Study. Maturitas, 13(1), 65–79.PubMedGoogle Scholar
  10. Avis, N. E., & McKinlay, S. M. (1995). The Massachusetts Women’s Health Study: An epidemiologic investigation of the menopause. Journal of American Medical Women’s Association, 50(2), 45–49.Google Scholar
  11. Aziz, A., Brannstrom, M., Berquist, C., & Silfverstolpe, G. (2005). Perimenopausal androgen decline after oophorectomy does not influence sexuality or psychological well-being. Fertility and Sterility, 83, 1021–1028.PubMedGoogle Scholar
  12. Ball, P., Knuppen, R., Haupt, M., & Breuer, H. (1972). Interactions between estrogens and catechol amines. 3. Studies on the methylation of catechol estrogens, catechol amines and other catechols by the ctechol-O-methyltransferases of human liver. Journal of Clinical Endocrinology Metabolism, 34(4), 736–746.PubMedGoogle Scholar
  13. Biegon, A. (1990). Effects of steroid hormones on the serotonergic system. Annals of the New York Academy of Sciences, 600, 426–432.Google Scholar
  14. Blehar, M. C., DePaulo, J. R. Jr., Gershon, E. S., Reich, T., Simpson, S. G., & Nurnberger, J. I. Jr. (1998). Women with bipolar disorder: Findings from the NIMH Genetics Initiative sample. Psychopharmacology Bulletin, 34(3), 239–243.PubMedGoogle Scholar
  15. Booij, L., Van Der Does, W., Benkelfat, C., Bremner, J. D., Cowen, P. J., Fava, M., et al. (2002). Predictors of mood response to acute tryptophan depletion. A reanalysis. Neuropsychopharmacology, 27(5), 852–861.PubMedGoogle Scholar
  16. Bromberger, J. T., Assmann, S. F., Avis, N. E., Schocken, M., Kravitz, H. M., & Cordal, A. (2003). Persistent mood symptoms in a multiethnic community cohort of pre- and perimenopausal women. American Journal of Epidemiology, 158(4), 347–356.PubMedGoogle Scholar
  17. Burger, H., Woods, N. F., Dennerstein, L., Alexander, J. L., Kotz, K., & Richardson, G. (2007). Nomenclature and endocrinology of menopause and perimenopause. Expert Review of Neurotherapies, 7(Suppl. 11), 35–43.Google Scholar
  18. Burt, V. K., Alshuler, L. L., & Rasgon, N. (1998). Depressive symptoms in the perimenopause: Prevalence, assessment, and guidelines for treatment. Harvard Review of Psychiatry, 6, 121–132.PubMedGoogle Scholar
  19. Campbell, S., & Whitehead, M. (1977). Oestrogen therapy and the menopausal syndrome. Clinics in Obstetrics and Gynaecology, 4, 31–47.PubMedGoogle Scholar
  20. Chang, S. H., Kim, C. S., Lee, K. S., Kim, H., Yim, S. V., Lim, Y. J., et al. (2007). Premenopausal factors influencing premature ovarian failure and early menopause. Maturitas, 58(1), 19–30.PubMedGoogle Scholar
  21. Cohen, L. S., Soares, C. N., Vitonis, A. F., Otto, M. W., & Harlow, B. L. (2006). Risk for new onset of depression during the menopausal transition: The Harvard study of moods and cycles. Archives of General Psychiatry, 63(4), 385–390.PubMedGoogle Scholar
  22. Cone, R. I., Davis, G. A., & Goy, R. W. (1981). Effects of ovarian steroids on serotonin metabolism within grossly dissected and microdissected brain regions of the ovariectomized rat. Brain Research Bulletin, 7, 639–644.PubMedGoogle Scholar
  23. Coulam, C. B., Adamson, S. C., & Annegers, J. F. (1986). Incidence of premature ovarian failure. Obstetrics and Gynecology, 67(4), 604–606.PubMedGoogle Scholar
  24. Davies, J., & Doyle, P. (2002). Quality of life studies in unselected gynecological outpatients and inpatients before and after hysterectomy. Journal of Obstetrics and Gynecology, 22, 523–526.Google Scholar
  25. Deecher, D., Andree, T. H., Sloan, D., & Schechter, L. E. (2008). From menarche to menopause: Exploring the underlying biology of depression in women experiencing hormonal changes. Psychoneuroendocrinology, 33, 3–17.PubMedGoogle Scholar
  26. Deeks, A. A., & McCabe, M. P. (2004). Well-being and menopause: An investigation of purpose in life, self-acceptance and social role in premenopausal, perimenopausal and postmenopausal women. Quality of Life Research, 13(2), 389–398.PubMedGoogle Scholar
  27. Dennerstein, L. (1996). Well-being, symptoms and the menopausal transition. Maturitas, 23(2), 147–157.PubMedGoogle Scholar
  28. Dennerstein, L., Dudly, E., & Burger, H. (2001). Are changes in sexual functioning during midlife due to aging or menopause? Fertility and Sterility, 76, 456–460.PubMedGoogle Scholar
  29. Dennerstein, L., Guthrie, J. R., Clark, M., Lehert, P., & Henderson V. W. (2004). A population-based study of depressed mood in middle-aged, Australian-born women. Menopause, 11(5), 563–568.PubMedGoogle Scholar
  30. Dennerstein, L., Lehert, P., & Burger, H. (2005a). The relative effects of hormones and relationship factors on sexual function of women through the natural menopausal transition. Fertility and Sterility, 84, 174–180.Google Scholar
  31. Dennerstein, L., Lehert, P., Burger, H., & Dudley, E. (1999). Mood and the menopausal transition. Journal of Nervous Mental Disease, 187(11), 685–691.Google Scholar
  32. Dennerstein, L., Lehert, P., Burger, H., & Guthrie, J. (2005b). Sexuality. The American Journal of Medicine, 118(12B), 59S–63S.Google Scholar
  33. Dennerstein, L., Smith, A. M., & Morse, C. (1994). Psychological well-being, mid-life and the menopause. Maturitas, 20(1), 1–11.PubMedGoogle Scholar
  34. El-Guebaly, N., Atchison, B., & Hay, W. (1984). The menopause: Stressors and facilitators. Canadian Medical Association Journal, 131(8), 865–869.Google Scholar
  35. Farquhar, C., Harvey, S., Yu, Y., Sadler, L., & Stewart, A. (2006). A prospective study of 3 years of outcomes after hysterectomy with and without oophorectomy. American Journal of Obstetrics and Gynecology, 194, 711–717.PubMedGoogle Scholar
  36. Freeman, E. W., Sammel, M. D., Lin, H., Gracia, C. R., Kapoor, S., & Ferdousi, T. (2005). The role of anxiety and hormonal changes in menopausal hot flashes. Menopause, 12, 258.PubMedGoogle Scholar
  37. Freeman, E. W., Sammel, M. D., Liu, L., Gracia, C. R., Nelson, D. B., & Hollander, L. (2004). Hormones and menopausal status as predictors of depression in women in transition to menopause. Archives of General Psychiatry, 61(1), 62–70.PubMedGoogle Scholar
  38. Freeman, E. W., Sammel, M. D., Lin, H., Gracia, C. R., Pien, G. W., Nelson, D. B., et al. (2007). Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstetrics and Gynecology, 110(2), 230–240.PubMedGoogle Scholar
  39. Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006). Associations of hormones and menopausal status with depressed mood in women with no history of depression. Archives of General Psychiatry, 63(4), 375–382.PubMedGoogle Scholar
  40. Freeman, M. P., Smith, K. W., Freeman, S. A., McElroy, S. L., Kmetz, G. E., Wright, R., et al. (2002). The impact of reproductive events on the course of bipolar disorder in women. Journal of Clinical Psychiatry, 63(4), 284–287.PubMedGoogle Scholar
  41. Friedman, S. H., Sajatovic, M., Schuermeyer, I. N., Safavi, R., Hays, R. W., West, J., et al. (2005). Menopause-related quality of life in chronically mentally ill women. International Journal of Psychiatry in Medicine, 35(3), 259–271.PubMedGoogle Scholar
  42. Gordon, J. H. (1980). Modulation of apomorphine-induced stereotypy by estrogen: Time course and dose response. Brain Research Bulletin, 5(6), 679–682.PubMedGoogle Scholar
  43. Gracia, C. R., Freeman, E. W., Sammel, M. D., Lin, H., & Mogul, M. (2007). Hormones and sexuality during transition to menopause. Obstetrics and Gynecology, 109(4), 831–840.PubMedGoogle Scholar
  44. Graziottin, A. (2007). Prevalence and evaluation of sexual health problems—HSDD in Europe. Journal of Sexual Medicine, 4(Suppl. 3), 211–219.PubMedGoogle Scholar
  45. Guicheney, P., Leger, D., Barrat, J., Trevoux, R., De Lignieres, B., Roques, P., et al. (1988). Platelet serotonin content and plasma tryptophan in peri- and postmenopausal women: Variations with plasma oestrogen levels and depressive symptoms. European Journal of Clinical Investigation, 18(3), 297–304.Google Scholar
  46. Halbreich, U., Rojansky, N., Palter, S., Tworek, H., Hissin, P., & Wang, K. (1995). Estrogen augments serotonergic activity in postmenopausal women. Biological Psychiatry, 37, 434–341.PubMedGoogle Scholar
  47. Hallonquist, J. D., Seeman, M. V., Lang, M., & Rector, N. A. (1993). Variation in symptom severity over the menstrual cycle of schizophrenics. Biological Psychiatry, 33(3), 207–209.PubMedGoogle Scholar
  48. Harlow, B. L., Cramer, D. W., & Annis, K. M. (1995). Association of medically treated depression and age at natural menopause. American Journal of Epidemiology, 141(12), 1170–1176.Google Scholar
  49. Harlow, B. L., & Signorello, L. B. (2000). Factors associated with early menopause. Maturitas, 35(1), 3–9.PubMedGoogle Scholar
  50. Harlow, B. L., Wise, L. A., Otto, M. W., Soares, C. N., & Cohen, L. S. (2003). Depression and its influence on reproductive endocrine and menstrual cycle markers associated with menopausal transition: The Harvard Study of Moods and Cycles. Journal of Women’s Health and Gender Based Medicine, 60, 29–36.Google Scholar
  51. Hartmann, U., Philippsohn, S., Heiser, K., & Ruffer-Hesse, C. (2004). Low sexual desire in midlife and older women: Personality factors, psychosocial development, present sexuality. Menopause, 11(6), 726–740.PubMedGoogle Scholar
  52. Hunter, M. (1992). The south-east England longitudinal study of the climacteric and postmenopause. Maturitas, 14(2), 117–26.PubMedGoogle Scholar
  53. Joffe, H., Hall, J. E., Soares, C. N., Hennen, J., Reilly, C. J., Carlson, K., et al. (2002). Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care. Menopause, 9, 392.PubMedGoogle Scholar
  54. Kaufert, P. A., Gilbert, P., & Tate, R. (1992). The Manitoba Project: A re-examination of the link between menopause and depression. Maturitas, 14(2), 143–155.PubMedGoogle Scholar
  55. Kjerulff, K., Langenberg, P., Rhodes, J., Harvey, L. A., Guzinski, G. M., & Stolley, P. D. (2000). Effectiveness of hysterectomy. Obstetrics and Gynecology, 95(3), 319–326.PubMedGoogle Scholar
  56. Klaiber, E. L., Broverman, D. M., Vogel, W., & Kobayashi, Y. (1979). Estrogen therapy for severe persistent depressions in women. Archives of General Psychiatry, 36, 550–554.PubMedGoogle Scholar
  57. Kravitz, H. M., Ganz, P. A., Bromberger, J., Powell, L. H., Sutton-Tyrrel, K., & Meyer, P. M. (2003). Sleep difficulty in women at midlife: A community survey of sleep and the menopausal transition. Menopause, 10, 19–28.PubMedGoogle Scholar
  58. Kuh, D. L., Wadsworth, M., & Hardy, R. (1997). Women’s health in midlife: The influence of the menopause, social factors and health in earlier life. British Journal of Obstetrics and Gynaecolgy, 104, 923–933.Google Scholar
  59. Kukopulos, A., Reginaldi, D., Laddomada, P., Floris, G., Serra, G., & Tondo, L. (1980). Course of the manic-depressive cycle and changes caused by treatment. Pharmakopsychiatrie Neuropsychopharmakologie, 13(4), 156–167.Google Scholar
  60. Kumar, M. S., Chen, C. L., & Muther, T. F. (1979). Changes in the pituitary and hypothalamic content of methionine-enkephalin during the estrous cycle of rats. Life Sciences, 25(19), 1687–1696.Google Scholar
  61. Landau, S., & Milan, F. B. (1996). Assessment and treatment of depression during the menopause: A preliminary report. Menopause, 3, 201–207.Google Scholar
  62. Leppert, P. C., Legro, R. S., & Kjerulff, K. H. (2007). Hysterectomy and loss of fertility: Implications for women’s mental health. Journal of Psychosomatic Research, 63, 269–274.PubMedGoogle Scholar
  63. Liao, K. L., Wood, N., & Conway, G. S. (2000). Premature menopause and psychological well-being. Journal of Psychosomatic Obstetrics and Gynecology, 21(3), 167–174.PubMedGoogle Scholar
  64. Lindamer, L. A., Lohr, J. B., Harris, M. J., & Jeste, D. V. (1997). Gender, estrogen, and schizophrenia. Psychopharmacology Bulletin, 33(2), 221–228.PubMedGoogle Scholar
  65. Luine, V. N., Khylchevskaya, R. I., & McEwen, B. (1975). Effect of gonadal steroids on activities of monoaminooxidase and choline acetylase in rat brain. Brain Research, 86, 293–306.PubMedGoogle Scholar
  66. Maciejewski, P. K., Prigerson, H. G., & Mazure, C. M. (2001). Sex differences in event-related risk for major depression. Psychological Medicine, 31(4), 593–604.PubMedGoogle Scholar
  67. Martens, L. W., Leusink, G. L., Knottnerus, J. A., Smeets, C. G., & Pop, V. J. (2001). Climacteric complaints in the community. Family Practice, 18, 189–194.Google Scholar
  68. Matthews, K. A. (1992). Myths and realities of the menopause. Psychosomatic Medicine, 54, 1–9.PubMedGoogle Scholar
  69. McKinlay, S. M. (1996). The normal menopause transition: An overview. Maturitas, 23, 137–145.PubMedGoogle Scholar
  70. McKinlay, S. M., & Jefferys, M. (1974). The menopausal syndrome. British Journal of Preventive and Social Medicine, 28, 108–115.PubMedGoogle Scholar
  71. McKinlay, J. B., McKinlay, S. M., & Brambilla, D. (1987). The relative contributions of endocrine changes and social circumstances to depression in mid-aged women. Journal of Health and Social Behavior, 28(4), 345–363.PubMedGoogle Scholar
  72. Meltzer, H. Y. (1990). Role of serotonin in depression. Annals of the New York Academy of Sciences, 600, 486–500.Google Scholar
  73. Mitchell, E. S., & Woods, N. F. (1996). Symptom experiences of midlife women: Observations from the Seattle Midlife Women’s Health Study. Maturitas, 25(1), 1–10.PubMedGoogle Scholar
  74. Moreno, F. A., McGahuey, C. A., Freeman, M. P., & Delgado, P. L. (2006). Sex differences in depressive response during monoamine depletions in remitted depressive subjects. Journal of Clinical Psychiatry, 67(10), 1618–1623.Google Scholar
  75. Morrison, J. H., Brinton, R. D., Schmidt, P. J., & Gore, A. C. (2006). Estrogen, menopause, and the aging brain: How basic neuroscience can inform hormone therapy in women. Journal of Neuroscience, 26(41), 10332–10348.PubMedGoogle Scholar
  76. Morrison, M. F., Kallan, M. J., Have, T. T., Katz, I., Tweedy, K., & Battistini, M. (2004). Lack of efficacy of estadiol for depression in postmenpausal women: A randomized, controlled trial. Biological Psychiatry, 55, 406–412.PubMedGoogle Scholar
  77. National Institutes of Health. (2005, March 21–23). NIH State-of-the-Science Conference Statement on Management of Menopause-Related Symptoms. State-of-the-Science Conference Statement.Google Scholar
  78. Nelson, D. B., Sammel, M. D., Freeman, E. W., Liu, L., Langan, E., & Gracia, C. R. (2004). Predicting participation in prospective studies of ovarian aging. Menopause, 11(5), 543–548.PubMedGoogle Scholar
  79. Nelson, H. D., Vesco, K. K., Haney, E., Fu, R., Nedrow, A., Miller, J., et al. (2006). Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. Journal of the American Medical Association, 295(17), 2057–2071.PubMedGoogle Scholar
  80. North American Menopause Society. (2000). Clinical challenges of perimenopause: Consensus opinion of the North American Menopause Society. Menopause, 7, 5–13.Google Scholar
  81. Novaes, C., Almeida, O. P., & de Melo, N. R. (1998). Mental health among perimenopausal women attending a menopause clinic: Possible association with premenstrual syndrome? Climacteric, 1(4), 264–270.PubMedGoogle Scholar
  82. Osborn, M., Hawton, K., & Gath, D. (1988). Sexual dysfunction among middle-aged women in the community. British Medical Journal, 296, 959–962.PubMedGoogle Scholar
  83. Pham, K. C., Grisso, J. A., & Freeman, E. W. (1997). Ovarian Aging and Hormone Replacement Therapy Hormonal Levels, Symptoms, and Attitudes of African-American and White Women. Journal of General Internal Medicine, 12, 230–236.PubMedGoogle Scholar
  84. Prange, A. J., Wilson, I. C., & Alltop, L. B. (1972). Estrogen may well affect response to antidepressants. Journal of the American Medical Association, 219, 143–144.Google Scholar
  85. Rapkin, A. J., Mikacich, J. A., Moatakef-Imani, B., & Rasgon, N. (2002). The clinical nature and formal diagnosis of premenstrual, postpartum, and perimenopausal affective disorders. Current Psychiatry Reports, 4(6), 419–428.PubMedGoogle Scholar
  86. Rasgon, N. L., Dunkin, J., Fairbanks, L., Altshuler, L. L., Troung, C., Elman, S., et al. (2007). Estrogen and response to sertraline in postmenopausal women with major depressive disorder: A pilot study. Journal of Psychiatric Research, 41(3–4), 338–343.PubMedGoogle Scholar
  87. Rasgon, N., Shelton, S., & Halbreich, U. (2005). Perimenopausal mental disorders: Epidemiology and phenomenology. CNS Spectrums, 10(6), 471–478.PubMedGoogle Scholar
  88. Reed, S. D., Newton, K. M., LaCroix, A. Z., Grothaus, L. C., & Ehrlich, K. (2007). Night sweats, sleep disturbance, and depression associated with diminished libido in late menopausal transition and early postmenopause: Baseline data from the Herbal Alternative for Menopause Trial (HALT). American Journal of Obstetrics and Gynecology, 196, 593.e1–593.e7.PubMedGoogle Scholar
  89. Rehman, H. U., & Masson, E. A. (2005). Neuroendocrinology of female aging. Gender Medicine, 2(1), 41–56.Google Scholar
  90. Riecher-Rössler, A., Häfner, H., Dütsch-Strobel, A., Oster, M., Stumbaum, M., van Gülick-Bailer, M., et al. (1994). Further evidence for a specific role of estradiol in schizophrenia? Biological Psychiatry, 36(7), 492–494.PubMedGoogle Scholar
  91. Rödström, K., Bengtsson, C., Lissner, L., Milsom, I., Sundh, V., & Björkelund, C. (2002). A longitudinal study of the treatment of hot flushes: The population study of women in Gothenburg during a quarter of a century. Menopause, 9(3), 156–161.PubMedGoogle Scholar
  92. Rosen, R., Brown, C., Heiman, J., Leiblum, S., Meston, C., Shabsigh, R., et al. (2000). The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. Journal of Sex & Marital Therapy, 26(2), 191–208.Google Scholar
  93. Sajatovic, M., Friedman, S. H., Schuermeyer, I. N., Safavi, R., Ignacio, R. V., Hays, R. W., et al. (2006). Menopause knowledge and subjective experience among peri- and postmenopausal women with bipolar disorder, schizophrenia and major depression. Journal of Nervous Mental Disease, 194(3), 173–178.Google Scholar
  94. Saletu, B., Brandstatter, N., Metka, M., Stamenkovic, M., Anderer, P., Semlitsch, H. V., et al. (1996). Hormonal syndromal and EEG mapping studies in menopausal syndrome patients with and without depression compared with controls. Maturitas, 23, 91–105.PubMedGoogle Scholar
  95. Santoro, N., Brown, J. R., Adel, T., & Skurnick, J. H. (1996). Characterization of reproductive hormonal dynamics in the perimenopause. Journal of Clinical Endocrinology & Metabolism, 81(4), 1495–1501.Google Scholar
  96. Schmidt, P. J. (2005). Mood, depression, and reproductive hormones in the menopausal transition. American Journal of Medicine, 118(Suppl. 12B), 54–58.PubMedGoogle Scholar
  97. Schmidt, P. J., Haq, N., & Rubinow, D. R. (2004a). A longitudinal evaluation of the relationship between reproductive status and mood in perimenopausal women. American Journal of Psychiatry, 161(12), 2238–2244.Google Scholar
  98. Schmidt, P. J., Murphy, J. H., Haq, N., Danaceau, M. A., & St. Clair, L. (2002). Basal plasma hormone levels in depressed perimenopausal women. Psychoneuroendocrinology, 27(8), 907–920.PubMedGoogle Scholar
  99. Schmidt, P. J., Murphy, J. H., Haq, N., Rubinow, D. R., & Danaceau, M. A. (2004b). Stressful life events, personal losses, and perimenopause-related depression. Archives of Women’s Mental Health, 7(1), 19–26.Google Scholar
  100. Schmidt, P. J., & Rubinow, D. R. (2006). Reproductive ageing, sex steroids and depression. The Journal of the British Menopause Society, 12(4), 178–185.PubMedGoogle Scholar
  101. Schneider, L. S, Small, G. W., Hamilton, S. H., Bystritsky, A., Nemeroff, C. B., & Meyers, B. S. (1997). Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. Fluoxetine Collaborative Study Group. American Journal of Geriatric Psychiatry, 5(2), 97–106.Google Scholar
  102. Shapira, B., Oppenheim, G., Zohar, J., Segal, M., Malach, D., & Belmaker, R. H. (1985). Lack of efficacy of estrogen supplementation to imipramine in resistant female depressives. Biological Psychiatry, 20, 576–579.PubMedGoogle Scholar
  103. Sherwin, B. B., & Suranyi-Cadotte, B. E. (1990). Up-regulatory effect of estrogen on platelet 3H-imipramine binding sites in surgically postmenopausal women. Biological Psychiatry, 28, 339–348.PubMedGoogle Scholar
  104. Shifren, J. L., & Avis, N. E. (2007). Surgical menopause: Effects on psychological well-being and sexuality. Menopause, 14(3), 586–591.PubMedGoogle Scholar
  105. Shors, T. J., & Leuner, B. (2003). Estrogen-mediated effects on depression and memory formation in females. Journal of Affective Disorders, 74, 85–96.PubMedGoogle Scholar
  106. Simpkins, J. W. (1984). Spontaneous skin flushing episodes in the aging female rat. Maturitas, 6(3), 269–278.PubMedGoogle Scholar
  107. Smith, A. M., Shelley, J. M., & Dennerstein, L. (1994). Self-rated health: Biological continuum or social discontinuity? Social Science and Medicine, 39(1), 77–83.PubMedGoogle Scholar
  108. Soares, C. N., Poitras, J. R., & Prouty, J. (2003). Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause. Drugs and Aging, 20, 85–100.PubMedGoogle Scholar
  109. Soules, M. R., Sherman, S., Parrott, E., Rebar, R., Santoro, N., Utian, W., et al. (2001). Stages of reproductive aging workshop (STRAW). Journal of Women’s Health & Gender-Based Medicine, 10(9), 843–848.Google Scholar
  110. Stewart, D. E., & Boydell, K. M. (1993). Psychologic distress during menopause: Associations across the reproductive life cycle. International Journal of Psychiatry in Medicine, 23, 157–162.PubMedGoogle Scholar
  111. Wiegel, M., Meston, C., & Rosen, R. (2005). The female sexual function index (FSFI): Cross-validation and development of clinical cutoff scores. Journal of Sex and Marital Therapy, 32, 1–20.Google Scholar
  112. Williams, R. E., Kalilani, L., Dibenedetti, D. B., Zhou, X., Granger, A. L., Fehnel, S. E., et al. (2008). Frequency and severity of vasomotor symptoms among peri- and postmenopausal women in the United States. Climacteric, 11(1), 32–43.PubMedGoogle Scholar
  113. Wise, L. A., Krieger, N., Zierler, S., & Harlow, B. L. (2002). Lifetime socioeconomic position in relation to onset of perimenopause. Journal of Epidemiology and Community Health, 56(11), 851–860.Google Scholar
  114. Wood, J. M., Mansfield, P. K., & Koch, P. B. (2007). Negotiating sexual agency: Postmenopausal women’s meaning and experience of sexual desire. Qualitative Health Research, 17, 189–200.PubMedGoogle Scholar
  115. Woods, N. F., Mariella, A., & Mitchell, E. S. (2002). Patterns of depressed mood across the menopausal transition: Approaches to studying patterns in longitudinal data. Acta Obstetricia Et Gynecologica Scandinavica, 81(7), 623–632.Google Scholar
  116. Wylie, K., Daines, B., Jannini, E. A., Hallam-Jones, R., Boul, L., Wilson, L., et al. (2007). Loss of sexual desire in the postmenopausal woman. Journal of Sexual Medicine, 4(2), 395–405.Google Scholar

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Authors and Affiliations

  • Tonita Wroolie
    • 1
  • Megan Holcomb
  1. 1.Department of Psychiatry and Behavioral Sciences, Center for Neuroscience in Women’s HealthStanford University, School of MedicineStanfordUSA

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