Targeting Signal Transduction Pathways for the Treatment of Kaposi Sarcoma
Kaposi sarcoma (KS) is a multi-focal angioproliferative disease driven by infection of cells by Kaposi sarcoma herpesvirus/human herpesvirus-8 (KSHV/HHV8). KSHV/HHV8 infection activates numerous sequential and parallel signaling pathways creating an angiogenic–inflammatory state that leads to the development of Kaposi sarcoma. These pathways can be grouped into KSHV/HHV8- specific pathways and cellular growth/angiogenic pathways that are “pirated” by KSHV/HHV8. Advances in our understanding of the pathogenesis of KS parallel the clinical development of signal transduction inhibitors. This chapter reviews the signaling pathways active in KSHV/HHV8-infected cells and discusses the use of clinical inhibitors of these pathways in the treatment of KS.
KeywordsMigration Leukemia Heparin Serine Sarcoma
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