Targeting Signal Transduction Pathways for the Treatment of Kaposi Sarcoma
Kaposi sarcoma (KS) is a multi-focal angioproliferative disease driven by infection of cells by Kaposi sarcoma herpesvirus/human herpesvirus-8 (KSHV/HHV8). KSHV/HHV8 infection activates numerous sequential and parallel signaling pathways creating an angiogenic–inflammatory state that leads to the development of Kaposi sarcoma. These pathways can be grouped into KSHV/HHV8- specific pathways and cellular growth/angiogenic pathways that are “pirated” by KSHV/HHV8. Advances in our understanding of the pathogenesis of KS parallel the clinical development of signal transduction inhibitors. This chapter reviews the signaling pathways active in KSHV/HHV8-infected cells and discusses the use of clinical inhibitors of these pathways in the treatment of KS.
KeywordsVascular Endothelial Growth Factor Vascular Endothelial Growth Factor Expression Fibroblast Growth Factor Receptor Acquire Immune Deficiency Syndrome Vascular Endothelial Growth Factor Pathway
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