The Epidemiology of Cancer in People with HIV

  • Andrew E. Grulich
  • Diego Serraino
  • Denise Whitby


Three types of cancer, namely Kaposi’s sarcoma (KS), non-Hodgkin’s lymphoma (NHL), and cervical cancer, are formally designated as AIDS-defining cancers. KS occurs many thousandfold more commonly in people with HIV than in the general population and is causally associated with infection with human herpesvirus-8. Incidence of KS has greatly decreased in recent years in those populations of people with HIV who have access to highly active antiretroviral therapy (HAART). NHL occurs 50- to 100-fold more commonly in people with HIV than in the general population and in a proportion of cases is related to Epstein–Barr virus (EBV) infection. Use of HAART has also resulted in substantial declines in incidence of NHL. Cervical cancer occurs up to 20 times more commonly in people with HIV than in the general population, and rates have been little affected by HAART use in recent years.

In addition to the AIDS-defining cancers, it has recently become clear that a wider range of mostly viral-associated cancers occur at increased rates in people with HIV. These include Hodgkin’s disease, the range of anogenital and oropharyngeal human papillomavirus associated cancers, liver cancer, and conjunctival cancers. Whether or not other cancers – including lung cancer and non-melanoma skin cancer – are associated with HIV infection is the subject of ongoing study.


Cervical Cancer Hodgkin Lymphoma Primary Central Nervous System Lymphoma Anal Cancer Burkitt Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Adami, J., Gabel, H., Lindelof, B., Ekstrom, K., Rydh, B., Glimelius, B., et al. (2003). Cancer risk following organ transplantation: a nationwide cohort study in Sweden. Br J Cancer 89, 1221–1227.PubMedCrossRefGoogle Scholar
  2. Babiker, A., Darbyshire, J., Pezzotti, P., Porter, K., Rezza, G., Walker, S. A., et al. (2002). Changes over calendar time in the risk of specific first AIDS-defining events following HIV seroconversion, adjusting for competing risks. Int J Epidemiol 31, 951–958.PubMedCrossRefGoogle Scholar
  3. Bahl, S., Theis, B., Nishri, D., and Marrett, L. D. (2008). Changing incidence of AIDS-related Kaposi sarcoma and non-Hodgkin lymphoma in Ontario, Canada. Cancer Causes Control 19, 1251–1258.PubMedCrossRefGoogle Scholar
  4. Banks, P., and Warnke, R. (2001). Primary effusion lymphoma. In: Jaffe, E., Harris, N., Stein, H., and Vardiman, J., eds. Pathology and Genetics of Tumours of the Haematopoetic and Lymphoid Tissues – World Health Organisation Classification of Tumours, pp. 179–180 (Lyon, France: IARC Press).Google Scholar
  5. Bedimo, R., Chen, R. Y., Accortt, N. A., Raper, J. L., Linn, C., Allison, J. J., et al. (2004). Trends in AIDS-defining and non-AIDS-defining malignancies among HIV-infected patients: 1989–2002. Clin Infect Dis 39, 1380–1384.PubMedCrossRefGoogle Scholar
  6. Beral, V., and Newton, R. (1998). Overview of the epidemiology of immunodeficiency-associated cancers. J Natl Cancer Inst Monogr 23, 1–6.PubMedCrossRefGoogle Scholar
  7. Beral, V., Peterman, T. A., Berkelman, R. L., and Jaffe, H. W. (1990). Kaposi’s sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335, 123–128.PubMedCrossRefGoogle Scholar
  8. Beral, V., Peterman, T., Berkelman, R., and Jaffe, H. (1991). AIDS-associated non-Hodgkin lymphoma. Lancet 337, 805–809.PubMedCrossRefGoogle Scholar
  9. Bhaskaran, K., Brettle, R., Porter, K., and Walker, A. S. (2004). Systemic non-Hodgkin lymphoma in individuals with known dates of HIV seroconversion: incidence and predictors. AIDS 18, 673–681.PubMedCrossRefGoogle Scholar
  10. Birkeland, S. A., Lokkegaard, H., and Storm, H. H. (2000). Cancer risk in patients on dialysis and after renal transplantation. Lancet 355, 1886–1887.PubMedCrossRefGoogle Scholar
  11. Bouvard, V., Baan, R., Straif, K., Grosse, Y., Secretan, B., El Ghissassi, F., et al. (2009). A review of human carcinogens – Part B: biological agents. Lancet Oncology 10, 321–322.PubMedCrossRefGoogle Scholar
  12. Bower, M., Powles, T., Nelson, M., Mandalia, S., Gazzard, B., and Stebbing, J. (2006). Highly active antiretroviral therapy and human immunodeficiency virus-associated primary cerebral lymphoma. J Natl Cancer Inst 98, 1088–1091.PubMedCrossRefGoogle Scholar
  13. Bower, M., Powles, T., Nelson, M., Shah, P., Cox, S., Mandelia, S., and Gazzard, B. (2003). HIV-related lung cancer in the era of highly active antiretroviral therapy. AIDS 17, 371–375.PubMedCrossRefGoogle Scholar
  14. Bower, M., Powles, T., Newsom-Davis, T., Thirlwell, C., Stebbing, J., Mandalia, S., et al. (2004). HIV-associated anal cancer: has highly active antiretroviral therapy reduced the incidence or improved the outcome? J Acquir Immune Defic Syndr 37, 1563–1565.PubMedCrossRefGoogle Scholar
  15. Brettle, R. P., Foreman, A., and Povey, S. (1996). Clinical features of AIDS in the Edinburgh City Hospital cohort. Int J STD AIDS 7, 190–196.PubMedCrossRefGoogle Scholar
  16. Burkes, R. L., Meyer, P. R., Gill, P. S., Parker, J. W., Rasheed, S., and Levine, A. M. (1986). Rectal lymphoma in homosexual men. Arch Intern Med 146, 913–915.PubMedCrossRefGoogle Scholar
  17. CDC. (1985). Revision of the case definition of acquired immunodeficiency syndrome for national reporting – United States. MMWR 34, 373–375.Google Scholar
  18. Cancer IAfRo. (2007). Human Papillomaviruses, Vol. 90 (Lyon, France: IARC Press).Google Scholar
  19. Carpenter, L. M., Newton, R., Casabonne, D., Ziegler, J., Mbulaiteye, S., Mbidde, E., et al. (2008). Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: a case-control study in Uganda. Int J Cancer 122, 1319–1323.PubMedCrossRefGoogle Scholar
  20. Casabona, J., Melbye, M., and Biggar, R. J. (1991). Kaposi’s sarcoma and non-Hodgkin’s lymphoma in European AIDS cases. No excess risk of Kaposi’s sarcoma in Mediterranean countries. Int J Cancer 47, 49–53.PubMedCrossRefGoogle Scholar
  21. Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M., and Moore, P. S. (1994). Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 266, 1865–1869.PubMedCrossRefGoogle Scholar
  22. Chiao, E. Y., Giordano, T. P., Richardson, P., and El-Serag, H. B. (2008). Human immunodeficiency virus-associated squamous cell cancer of the anus: epidemiology and outcomes in the highly active antiretroviral therapy era. J Clin Oncol 26, 474–479.PubMedCrossRefGoogle Scholar
  23. Clifford, G. M., Polesel, J., Rickenbach, M., Dal Maso, L., Keiser, O., Kofler, A., et al. (2005). Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst 97, 425–432.PubMedCrossRefGoogle Scholar
  24. Clifford, G. M., Rickenbach, M., Polesel, J., Dal Maso, L., Steffen, I., Ledergerber, B., et al. (2008). Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma. AIDS 22, 2135–2141.PubMedCrossRefGoogle Scholar
  25. Cogliano, V., Baan, R., Straif, K., Grosse, Y., Secretan, B., and El Ghissassi, F. (2005). Carcinogenicity of human papillomaviruses. Lancet Oncol 6, 204.PubMedCrossRefGoogle Scholar
  26. Cote, T. R., Manns, A., Hardy, C. R., Yellin, F. J., and Hartge, P. (1996). Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome. AIDS/Cancer Study Group. J Natl Cancer Inst 88, 675–679.PubMedCrossRefGoogle Scholar
  27. Dal Maso, L., Franceschi, S., Polesel, J., Braga, C., Piselli, P., Crocetti, E., et al. (2003). Risk of cancer in persons with AIDS in Italy, 1985–1998. Br J Cancer 89, 94–100.PubMedCrossRefGoogle Scholar
  28. Dal Maso, L., Polesel, J., Serraino, D., and Franceschi, S. (2003). Lung cancer in persons with AIDS in Italy, 1985–1998. AIDS 17, 2117–2119.PubMedCrossRefGoogle Scholar
  29. Dal Maso, L., Polesel, J., Serraino, D., Lise, M., Piselli, P., Falcini, F., et al. (2009). Pattern of cancer risk in persons with AIDS in Italy in the HAART era. Br J Cancer 100, 840–847.PubMedCrossRefGoogle Scholar
  30. Dal Maso, L., Serraino, D., and Franceschi, S. (2001). Epidemiology of AIDS-related tumours in developed and developing countries. Eur J Cancer 37, 1188–1201.PubMedCrossRefGoogle Scholar
  31. Daling, J. R., Weiss, N. S., Hislop, T. G., Maden, C., Coates, R. J., Sherman, K. J., et al. (1987). Sexual practices, sexually transmitted diseases, and the incidence of anal cancer. N Engl J Med 317, 973–977.PubMedCrossRefGoogle Scholar
  32. de Koning, M. N., Waddell, K., Magyezi, J., Purdie, K., Proby, C., Harwood, C., et al. (2008). Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: a case-control study in Uganda. Infect Agent Cancer 3, 12.PubMedCrossRefGoogle Scholar
  33. Di Martino, V., Rufat, P., Boyer, N., Renard, P., Degos, F., Martinot-Peignoux, M., et al. (2001). The influence of human immunodeficiency virus coinfection on chronic hepatitis C in injection drug users: a long-term retrospective cohort study. Hepatology 34, 1193–1199.PubMedCrossRefGoogle Scholar
  34. Diamond, C., Taylor, T. H., Aboumrad, T., and Anton-Culver, H. (2006). Changes in acquired immunodeficiency syndrome-related non-Hodgkin lymphoma in the era of highly active antiretroviral therapy: incidence, presentation, treatment, and survival. Cancer 106, 128–135.PubMedCrossRefGoogle Scholar
  35. Diamond, C., Taylor, T. H., Aboumrad, T., Bringman, D., and Anton-Culver, H. (2005). Increased incidence of squamous cell anal cancer among men with AIDS in the era of highly active antiretroviral therapy. Sex Transm Dis 32, 314–320.PubMedCrossRefGoogle Scholar
  36. Dorfman, R. F., Burke, J. S., and Berard, C. W. (1982). A working formulation of non-Hodgkin’s lymphomas: background, recommendations, histological criteria, and relationship to other classifications. In: Rosenberg, S., and Kaplan, H. S., eds. Malignant Lymphomas, pp. 351–368 (New York, NY: Academic Press, Inc.).Google Scholar
  37. D’Souza, G., Wiley, D. J., Li, X., Chmiel, J. S., Margolick, J. B., Cranston, R. D., and Jacobson, L. P. (2008). Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study. J Acquir Immune Defic Syndr 48, 491–499.PubMedCrossRefGoogle Scholar
  38. Elford, J., McDonald, A., and Kaldor, J. (1993). Kaposi’s sarcoma as a sexually transmissible infection: an analysis of Australian AIDS surveillance data. The National HIV Surveillance Committee. AIDS 7, 1667–1671.PubMedCrossRefGoogle Scholar
  39. Ellerbrock, T. V., Chiasson, M. A., Bush, T. J., Sun, X. W., Sawo, D., Brudney, K., and Wright, T. C., Jr. (2000). Incidence of cervical squamous intraepithelial lesions in HIV-infected women. JAMA 283, 1031–1037.PubMedCrossRefGoogle Scholar
  40. Engels, E. A., Biggar, R. J., Hall, H. I., Cross, H., Crutchfield, A., Finch, J. L., et al. (2008). Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer 123, 187–194.PubMedCrossRefGoogle Scholar
  41. Engels, E. A., Brock, M. V., Chen, J., Hooker, C. M., Gillison, M., and Moore, R. D. (2006). Elevated incidence of lung cancer among HIV-infected individuals. J Clin Oncol 24, 1383–1388.PubMedCrossRefGoogle Scholar
  42. Engels, E. A., Frisch, M., Goedert, J. J., Biggar, R. J., and Miller, R. W. (2002). Merkel cell carcinoma and HIV infection. Lancet 359, 497–498.PubMedCrossRefGoogle Scholar
  43. Engels, E. A., Pfeiffer, R. M., Goedert, J. J., Virgo, P., McNeel, T. S., Scoppa, S. M., and Biggar, R. J. (2006). Trends in cancer risk among people with AIDS in the United States 1980–2002. AIDS 20, 1645–1654.PubMedCrossRefGoogle Scholar
  44. Feng, H., Shuda, M., Chang, Y., and Moore, P. S. (2008). Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319, 1096–1100.PubMedCrossRefGoogle Scholar
  45. Franceschi, S., Maso, L. D., Rickenbach, M., Polesel, J., Hirschel, B., Cavassini, M., et al. (2008). Kaposi sarcoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy. Br J Cancer 99, 800–804.PubMedCrossRefGoogle Scholar
  46. Frisch, M., Biggar, R. J., Engels, E. A., and Goedert, J. J. (2001). Association of cancer with AIDS-related immunosuppression in adults. JAMA 285, 1736–1745.PubMedCrossRefGoogle Scholar
  47. Frisch, M., Biggar, R. J., and Goedert, J. J. (2000). Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 92, 1500–1510.PubMedCrossRefGoogle Scholar
  48. Galceran, J., Marcos-Gragera, R., Soler, M., Romaguera, A., Ameijide, A., Izquierdo, A., et al. (2007). Cancer incidence in AIDS patients in Catalonia, Spain. Eur J Cancer 43, 1085–1091.PubMedCrossRefGoogle Scholar
  49. Gao, S. J., Kingsley, L., Li, M., Zheng, W., Parravicini, C., Ziegler, J., et al. (1996). KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi’s sarcoma. Nat Med 2, 925–928.PubMedCrossRefGoogle Scholar
  50. Giordano, T. P., and Kramer, J. R. (2005). Does HIV infection independently increase the incidence of lung cancer? Clin Infect Dis 40, 490–491.PubMedCrossRefGoogle Scholar
  51. Goedert, J. J., Cote, T. R., Virgo, P., Scoppa, S. M., Kingma, D. W., Gail, M. H., et al. (1998). Spectrum of AIDS-associated malignant disorders. Lancet 351, 1833–1839.PubMedCrossRefGoogle Scholar
  52. Graham, C. S., Baden, L. R., Yu, E., Mrus, J. M., Carnie, J., Heeren, T., and Koziel, M. J. (2001). Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis. Clin Infect Dis 33, 562–569.PubMedCrossRefGoogle Scholar
  53. Grulich, A. E. (1999). AIDS-associated non-Hodgkin’s lymphoma in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 21(Suppl 1), S27–S30.PubMedGoogle Scholar
  54. Grulich, A. E., Li, Y., McDonald, A. M., Correll, P. K., Law, M. G., and Kaldor, J. M. (2001). Decreasing rates of Kaposi’s sarcoma and non-Hodgkin’s lymphoma in the era of potent combination anti-retroviral therapy. AIDS 15, 629–633.PubMedCrossRefGoogle Scholar
  55. Grulich, A. E., van Leeuwen, M. T., Falster, M. O., and Vajdic, C. M. (2007). Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370, 59–67.PubMedCrossRefGoogle Scholar
  56. Guech-Ongey, M., Engels, E. A., Goedert, J. J., Biggar, R. J., and Mbulaiteye, S. M. (2008). Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States. Int J Cancer 122, 2590–2593.PubMedCrossRefGoogle Scholar
  57. Harris, N. L., Jaffe, E. S., Stein, H., Banks, P. M., Chan, J. K., Cleary, M. L., et al. (1994). A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84, 1361–1392.PubMedGoogle Scholar
  58. Herida, M., Mary-Krause, M., Kaphan, R., Cadranel, J., Poizot-Martin, I., Rabaud, C., et al. (2003). Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients. J Clin Oncol 21, 3447–3453.PubMedCrossRefGoogle Scholar
  59. Hermans, P., Lundgren, J., Sommereijns, B., Pedersen, C., Vella, S., Katlama, C., et al. (1996). Epidemiology of AIDS-related Kaposi’s sarcoma in Europe over 10 years. AIDS in Europe Study Group. AIDS 10, 911–917.PubMedCrossRefGoogle Scholar
  60. Hessol, N. A., Pipkin, S., Schwarcz, S., Cress, R. D., Bacchetti, P., and Scheer, S. (2007). The impact of highly active antiretroviral therapy on non-aids-defining cancers among adults with AIDS. Am J Epidemiol 165, 1143–1153PubMedCrossRefGoogle Scholar
  61. International Collaboration on HIV and Cancer. (2000). Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults. J Natl Cancer Inst 92, 1823–1830.CrossRefGoogle Scholar
  62. Jacobson, L. P., Munoz, A., Fox, R., Phair, J. P., Dudley, J., Obrams, G. I., et al. (1990). Incidence of Kaposi’s sarcoma in a cohort of homosexual men infected with the human immunodeficiency virus type 1. The Multicenter AIDS Cohort Study Group. J Acquir Immune Defic Syndr 3(Suppl 1), S24–S31.PubMedGoogle Scholar
  63. Jacobson, L. P., Yamashita, T. E., Detels, R., Margolick, J. B., Chmiel, J. S., Kingsley, L. A., et al. (1999). Impact of potent antiretroviral therapy on the incidence of Kaposi’s sarcoma and non-Hodgkin’s lymphomas among HIV-1-infected individuals. Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 21(Suppl 1), S34–S41.PubMedCrossRefGoogle Scholar
  64. Jaffe, E. S., Harris, N. L., Stein, H., and Vardiman, J. W., eds. (2001). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (Lyon, France: IARC Press).Google Scholar
  65. Kasiske, B. L., Snyder, J. J., Gilbertson, D. T., and Wang, C. (2004). Cancer after kidney transplantation in the United States. Am J Transplant 4, 905–913.PubMedCrossRefGoogle Scholar
  66. Kedes, D. H., Operskalski, E., Busch, M., Kohn, R., Flood, J., and Ganem, D. (1996). The seroepidemiology of human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 2, 918–924.PubMedCrossRefGoogle Scholar
  67. Kelly, G. L., and Rickinson, A. B. (2007). Burkitt lymphoma: revisiting the pathogenesis of a virus-associated malignancy. Hematology Am Soc Hematol Educ Program 2007, 277–284.CrossRefGoogle Scholar
  68. Kestelyn, P., Stevens, A. M., Ndayambaje, A., Hanssens, M., and van de Perre, P. H. I. V. (1990). conjunctival malignancies. Lancet 336, 51–52.PubMedCrossRefGoogle Scholar
  69. Kirk, G. D., Merlo, C., O’ Driscoll, P., Mehta, S. H., Galai, N., Vlahov, D., et al. (2007). HIV infection is associated with an increased risk for lung cancer, independent of smoking. Clin Infect Dis 45, 103–110.PubMedCrossRefGoogle Scholar
  70. Krown, S. E., Lee, J. Y., and Dittmer, D. P. (2008). More on HIV-associated Kaposi’s sarcoma. N Engl J Med 358, 535–536, author reply 536.PubMedCrossRefGoogle Scholar
  71. Kyllonen, L., Salmela, K., and Pukkala, E. (2000). Cancer incidence in a kidney-transplanted population. Transpl Int 13(Suppl 1), S394–S398.PubMedCrossRefGoogle Scholar
  72. Lanoy, E., Dores, G. M., Madeleine, M. M., Toro, J. R., Fraumeni, J. F., Jr., and Engels, E. A. (2009). Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS 23, 385–393.PubMedCrossRefGoogle Scholar
  73. Levine, A. M., Sullivan-Halley, J., Pike, M. C., Rarick, M. U., Loureiro, C., Bernstein-Singer, M., et al. (1991). Human immunodeficiency virus-related lymphoma. Prognostic factors predictive of survival. Cancer 68, 2466–2472.PubMedCrossRefGoogle Scholar
  74. Louie, J. K., Hsu, L. C., Osmond, D. H., Katz, M. H., and Schwarcz, S. K. (2002). Trends in causes of death among persons with acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy, San Francisco, 1994–1998. J Infect Dis 186, 1023–1027.PubMedCrossRefGoogle Scholar
  75. Martro, E., Esteve, A., Schulz, T. F., Sheldon, J., Gambus, G., Munoz, R., et al. (2007). Risk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi’s sarcoma among men who have sex with men in a European multicentre study. Int J Cancer 120, 1129–1135.PubMedCrossRefGoogle Scholar
  76. Maurer, T., Ponte, M., and Leslie, K. (2007). HIV-associated Kaposi’s sarcoma with a high CD4 count and a low viral load. N Engl J Med 357, 1352–1353.PubMedCrossRefGoogle Scholar
  77. McGinnis, K. A., Fultz, S. L., Skanderson, M., Conigliaro, J., Bryant, K., and Justice, A. C. (2006). Hepatocellular carcinoma and non-Hodgkin’s lymphoma: the roles of HIV, hepatitis C infection, and alcohol abuse. J Clin Oncol 24, 5005–5009.PubMedCrossRefGoogle Scholar
  78. Mocroft, A., Kirk, O., Clumeck, N., Gargalianos-Kakolyris, P., Trocha, H., Chentsova, N., et al. (2004). The changing pattern of Kaposi sarcoma in patients with HIV, 1994–2003: the EuroSIDA Study. Cancer 100, 2644–2654.PubMedCrossRefGoogle Scholar
  79. Morris, J. D., Eddleston, A. L., and Crook, T. (1995). Viral infection and cancer. Lancet 346, 754–758.PubMedCrossRefGoogle Scholar
  80. Morton, L. M., Turner, J. J., Cerhan, J. R., Linet, M. S., Treseler, P. A., Clarke, C. A., et al. (2007). Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph). Blood 110, 695–708.PubMedCrossRefGoogle Scholar
  81. Morton, L. M., Wang, S. S., Devesa, S. S., Hartge, P., Weisenburger, D. D., and Linet, M. S. (2006). Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood 107, 265–276.PubMedCrossRefGoogle Scholar
  82. Mutalima, N., Molyneux, E., Jaffe, H., Kamiza, S., Borgstein, E., Mkandawire, N., et al. (2008). Associations between Burkitt lymphoma among children in Malawi and infection with HIV, EBV and malaria: results from a case-control study. PLoS ONE 3, e2505.PubMedCrossRefGoogle Scholar
  83. Newnham, A., Harris, J., Evans, H. S., Evans, B. G., and Moller, H. (2005). The risk of cancer in HIV-infected people in southeast England: a cohort study. Br J Cancer 92, 194–200.PubMedCrossRefGoogle Scholar
  84. Newton, R., Carpenter, L., Casabonne, D., Beral, V., Babiker, A., Darbyshire, J., et al. (2006). A prospective study of Kaposi’s sarcoma-associated herpesvirus and Epstein-Barr virus in adults with human immunodeficiency virus-1. Br J Cancer 94, 1504–1509.PubMedCrossRefGoogle Scholar
  85. Newton, R., Ziegler, J., Ateenyi-Agaba, C., Bousarghin, L., Casabonne, D., Beral, V., et al. (2002). The epidemiology of conjunctival squamous cell carcinoma in Uganda. Br J Cancer 87, 301–308.PubMedCrossRefGoogle Scholar
  86. Newton, R., Ziegler, J., Beral, V., Mbidde, E., Carpenter, L., Wabinga, H., et al. (2001). A case-control study of human immunodeficiency virus infection and cancer in adults and children residing in Kampala, Uganda. Int J Cancer 92, 622–627.PubMedCrossRefGoogle Scholar
  87. Orlando, G., Tanzi, E., Beretta, R., Amendola, A., Fasolo, M. M., Bianchi, S., et al. (2008). Human papillomavirus genotypes and anal-related lesions among HIV-1-infected men in Milan, Italy. J Acquir Immune Defic Syndr 47, 129–131.PubMedCrossRefGoogle Scholar
  88. Osmond, D. H., Buchbinder, S., Cheng, A., Graves, A., Vittinghoff, E., Cossen, C. K., et al. (2002). Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. JAMA 287, 221–225.PubMedCrossRefGoogle Scholar
  89. Patel, P., Hanson, D. L., Sullivan, P. S., Novak, R. M., Moorman, A. C., Tong, T. C., et al. (2008). Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann Intern Med 148, 728–736.PubMedGoogle Scholar
  90. Piketty, C., Selinger-Leneman, H., Grabar, S., Duvivier, C., Bonmarchand, M., Abramowitz, L., et al. (2008). Marked increase in the incidence of invasive anal cancer among HIV-infected patients despite treatment with combination antiretroviral therapy. AIDS 22, 1203–1211.PubMedCrossRefGoogle Scholar
  91. Polesel, J., Clifford, G. M., Rickenbach, M., Dal Maso, L., Battegay, M., Bouchardy, C., et al. (2008). Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy. AIDS 22, 301–306.PubMedCrossRefGoogle Scholar
  92. Rezza, G., Dorrucci, M., Serraino, D., Andreoni, M., Giuliani, M., Zerboni, R., et al. (2000). Incidence of Kaposi’s sarcoma and HHV-8 seroprevalence among homosexual men with known dates of HIV seroconversion. Italian Seroconversion Study. AIDS 14, 1647–1653.PubMedCrossRefGoogle Scholar
  93. Robotin, M. C., Law, M. G., Milliken, S., Goldstein, D., Garsia, R. J., Dolan, G. M., et al. (2004). Clinical features and predictors of survival of AIDS-related non-Hodgkin’s lymphoma in a population-based case series in Sydney, Australia. HIV Med 5, 377–384.PubMedCrossRefGoogle Scholar
  94. Serraino, D., Angeletti, C., Carrieri, M. P., Longo, B., Piche, M., Piselli, P., et al. (2005). Kaposi’s sarcoma in transplant and HIV-infected patients: an epidemiologic study in Italy and France. Transplantation 80, 1699–1704.PubMedCrossRefGoogle Scholar
  95. Serraino, D., Boschini, A., Carrieri, P., Pradier, C., Dorrucci, M., Dal Maso, L., et al. (2000). Cancer risk among men with, or at risk of, HIV infection in southern Europe. AIDS 14, 553–559.PubMedCrossRefGoogle Scholar
  96. Serraino, D., Carbone, A., Franceschi, S., and Tirelli, U. (1993). Increased frequency of lymphocyte depletion and mixed cellularity subtypes of Hodgkin’s disease in HIV-infected patients. Italian Cooperative Group on AIDS and Tumours. Eur J Cancer 29A, 1948–1950.PubMedCrossRefGoogle Scholar
  97. Serraino, D., Piselli, P., Busnach, G., Burra, P., Citterio, F., Arbustini, E., et al. (2007). Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Eur J Cancer 43(14), 2117–2123.PubMedCrossRefGoogle Scholar
  98. Simpson, G. R., Schulz, T. F., Whitby, D., Cook, P. M., Boshoff, C., Rainbow, L., et al. (1996). Prevalence of Kaposi’s sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 348, 1133–1138.PubMedCrossRefGoogle Scholar
  99. Stebbing, J., Gazzard, B., Mandalia, S., Teague, A., Waterston, A., Marvin, V., et al. (2004). Antiretroviral treatment regimens and immune parameters in the prevention of systemic AIDS-related non-Hodgkin’s lymphoma. J Clin Oncol 22, 2177–2183.PubMedCrossRefGoogle Scholar
  100. Stein, L., Urban, M. I., O‘Connell, D., Yu, X. Q., Beral, V., Newton, R., et al. (2008). The spectrum of human immunodeficiency virus-associated cancers in a South African black population: results from a case-control study, 1995–2004. Int J Cancer 122, 2260–2265.PubMedCrossRefGoogle Scholar
  101. Thio, C. L., Seaberg, E. C., Skolasky, R., Jr., Phair, J., Visscher, B., Munoz, A., and Thomas, D. L. (2002). HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). Lancet 360, 1921–1926.PubMedCrossRefGoogle Scholar
  102. Vajdic, C. M., McDonald, S. P., McCredie, M. R., van Leeuwen, M. T., Stewart, J. H., Law, M., et al. (2006). Cancer incidence before and after kidney transplantation. JAMA 296, 2823–2831.PubMedCrossRefGoogle Scholar
  103. Vajdic, C. M., van Leeuwen, M. T., McDonald, S. P., McCredie, M. R., Law, M., Chapman, J. R., et al. (2007). Increased incidence of squamous cell carcinoma of eye after kidney transplantation. J Natl Cancer Inst 99, 1340–1342.PubMedCrossRefGoogle Scholar
  104. Waddell, K. M., Downing, R. G., Lucas, S. B., and Newton, R. (2006). Corneo-conjunctival carcinoma in Uganda. Eye 20, 893–899.PubMedCrossRefGoogle Scholar
  105. Waddell, K. M., Lewallen, S., Lucas, S. B., Atenyi-Agaba, C., Herrington, C. S., and Liomba, G. (1996). Carcinoma of the conjunctiva and HIV infection in Uganda and Malawi. Br J Ophthalmol 80, 503–508.PubMedCrossRefGoogle Scholar
  106. Weber, R., Sabin, C. A., Friis-Moller, N., Reiss, P., El-Sadr, W. M., Kirk, O., et al. (2006). Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med 166, 1632–1641.PubMedCrossRefGoogle Scholar
  107. Whitby, D. (2009). Searching for targets of viral microRNAs. Nat Genet 41, 7–8.PubMedCrossRefGoogle Scholar
  108. Whitby, D., Howard, M. R., Tenant-Flowers, M., Brink, N. S., Copas, A., Boshoff, C., et al. (1995). Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi’s sarcoma. Lancet 346, 799–802.PubMedCrossRefGoogle Scholar
  109. Wilkes, M. S., Fortin, A. H., Felix, J. C., Godwin, T. A., and Thompson, W. G. (1988). Value of necropsy in acquired immunodeficiency syndrome. Lancet 2, 85–88.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Andrew E. Grulich
    • 1
  • Diego Serraino
    • 2
  • Denise Whitby
    • 3
  1. 1.National Centre in HIV Epidemiology and Clinical Research, University of New South WalesSydney 2010Australia
  2. 2.Epidemiology and Biostatistics, IRCCS Centro di Riferimento OncologicoAvianoItaly
  3. 3.Viral Oncology Section, AIDS and Cancer Virus Program, Viral Epidemiology LaboratorySAIC-Frederick NCI-FrederickFrederickUSA

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