Analytical Epidemiology in Genetic Epidemiology

  • Jørn Olsen
  • Kaare Christensen
  • Jeff Murray
  • Anders Ekbom
Part of the Springer Series on Epidemiology and Public Health book series (SSEH, volume 1)


The recurrence of diseases or correlation in traits can, through studies of adoptees, twins, and half-sibs, provide information about the causes of familial clustering. Other kinds of family studies cannot separate the effect of shared environment and shared genes.


Twin Pair Twin Study Monozygotic Twin Dizygotic Twin Adoption Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Heston LL. Psychiatric disorders in foster home reared children of schizophrenic mothers. Br J Psychiatry 1966;112(489):819–825.PubMedCrossRefGoogle Scholar
  2. 2.
    Plomin R, Owen MJ, McGuffin P. The genetic basis of complex human behaviors. Science 1994 Jun 17;264(5166):1733–1739. Review.PubMedCrossRefGoogle Scholar
  3. 3.
    Sørensen TI, Holst C, Stunkard AJ. Adoption study of environmental modifications of the genetic influences on obesity. Int Obes Relat Metab Disord 1998;22(1):73–81.CrossRefGoogle Scholar
  4. 4.
    Olsen J, Schmidt MM, Christensen K. Evaluation of nature-nurture impact on reproductive health using half-siblings. Epidemiology 1997;8(1):6–11.PubMedCrossRefGoogle Scholar
  5. 5.
    Doll R, Hill AB. Smoking and carcinoma of the lung. Br Med J 1950;4682:739–748.CrossRefGoogle Scholar
  6. 6.
    Kujala UM, Kaprio J, Koskenvuo M. Modifiable risk factors as predictors of all-cause mortality: the roles of genetics and childhood environment. Am J Epidemiol 2002;156(11):985–993.PubMedCrossRefGoogle Scholar
  7. 7.
    Christensen K, Murray JC. What genome-wide association studies can do for medicine. N Engl J Med 2007 Mar 15;356(11):1094–1097.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jørn Olsen
    • 1
  • Kaare Christensen
    • 2
  • Jeff Murray
    • 3
  • Anders Ekbom
    • 4
  1. 1.School of Public HealthUniversity of California, Los AngelesLos AngelesUSA
  2. 2.Institute of Public HealthUniversity of Southern DenmarkOdense CDenmark
  3. 3.Department of Pediatrics, 2182 MedLabsUniversity of IowaIowa CityUSA
  4. 4.Department of MedicineKarolinska InstitutetStockholmSweden

Personalised recommendations