Assessing Thyroid Function in Pregnancy

Chapter
Part of the Thyroid Function Testing book series (ENDO, volume 28)

Abstract

The role of iodine in ensuring normal fetal development has been appreciated for more than 100 years [1]. Cretinism, defined as an infant or child with an IQ of 40 or less, was described in many severely iodine-deficient areas of the world and prevention of this state was achieved by iodine supplementation before or early in gestation [2]. It was not thought that thyroid hormone crossed the placental barrier to enter the developing fetus until the opposite was shown in 1989 [3]. Not only has this physiological fact now been verified, but there is now a wealth of data on the importance of maternal-derived thyroxine (T4) in fetal brain development (Table 11.1).

Keywords

Migration Filtration Albumin Carbohydrate Estrogen 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Centre for Endocrine and Diabetes SciencesUniversity Hospital of WalesWalesUK

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