The primary focus of this chapter will be on systemic lupus erythematosus (SLE), a multisystem autoimmune disorder that most frequently affects young women, although we will later make some remarks regarding asthma and its relation to life stress and synergism with air pollution. In SLE, arthritis, skin rash, osteoporosis, cataracts, accelerated atherosclerotic vascular disease (ASVD), central nervous system dysfunction, and renal disease, are the most common manifestations. The severity of symptoms may markedly fluctuate over time, and the damage of the disease is of ‘Type III’, i.e., mediated by immune complexes ranging from just a few molecules to relatively huge structures involving whole cells coated or cross-linked by antibody.
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