Chemoprevention of Head and Neck Cancers

  • William N. WilliamJr.
  • Christopher H. Lieu
  • Scott M. Lippman


The term “chemoprevention” in reference to cancer was introduced by Sporn in 1976 and was defined as the use of natural, synthetic, or biologic compounds to halt, reverse, or prevent the initial phase of carcinogenesis or the progression of neoplastic cells to cancer [1] . The following three key biologic features of malignant transformation support the development of chemopreventive strategies: it involves the multipath, multistep, and multifocal disruption of normal cellular function.


Oral Cancer Allelic Imbalance Oral Leukoplakia Retinyl Palmitate Oral Epithelial Dysplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • William N. WilliamJr.
    • 1
  • Christopher H. Lieu
    • 1
  • Scott M. Lippman
    • 1
  1. 1.Department of Thoracic/Head and Neck Medical OncologyThe University of Texas M. D. Anderson Cancer CenterHouston, TXUSA

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