Descriptive Epidemiology: International Patterns

  • Mia Hashibe
  • Jacques Ferlay
  • Rengaswamy Sankaranarayanan


Head and neck cancers (HNC) are a group of neoplasms common in several regions of the world where the prevalence of tobacco habits and alcohol consumption in the population is high. These cancers accounted for 420,000 new cases among males and 142,000 incident cases among females in 2002 around the world (Table 1 ) [1] . They are responsible for 8% of male (257,779/3,092,119) and 4% of female cancers (101,654/2,735,386) in the developing world. In developed countries, they account for 6% of male (163,377/2,698,175) and 2% of female cancers (40,762/2,317,939). The incidence rate of HNC and the distribution of cancers in head and neck anatomical subsites vary greatly in different geographical regions. The variation in cancer distribution by subsites is most likely due to differences in the relative distribution of the known risk factors such as tobacco chewing, smoking, and alcohol consumption. Misclassification of subsites is also a possibility due to the difficulties in assigning the primary site of origin, especially due to the anatomical proximity between the various subsites (for example, cancers of the supraglottic larynx and hypopharynx). However, patterns of disease distribution provide valuable clues for disease prevention and control. We will review the global geographical distribution and trends in incidence and mortality of HNC.


Neck Cancer Laryngeal Cancer Hypopharyngeal Cancer Oral Cavity Cancer Descriptive Epidemiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ferlay J, Bray F, Pisani P, Parkin DM (2004) GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide, version 2.0. IARC CancerBase No. 5. IARCPress, LyonGoogle Scholar
  2. 2.
    Percy C, Van Holten V, Muir C (1990) International Classification of Diseases for Oncology, 2nd edn. World Health Organization, GenevaGoogle Scholar
  3. 3.
    Sun EC, Curtis R, Melbye M, Goedert JJ (1999) Salivary gland cancer in the United States. Cancer Epidemiol Biomarkers Prev 8:1095–100PubMedGoogle Scholar
  4. 4.
    Spano JP, Busson P, Atlan D, Bourhis J, Pignon JP, Esteban C, Armand JP (2003) Nasopharyngeal carcinomas: an update. Eur J Cancer 39(15):2121–35PubMedCrossRefGoogle Scholar
  5. 5.
    Curado MP, Edwards B, Shin HR, Storm H, Ferlay J, Heanue M, Boyle P (2007) Cancer incidence in five continents. IARC Scientific Publications, No. 160, LyonGoogle Scholar
  6. 6.
    Ries LAG, Melbert D, Krapcho M, Stinchcomb DG, Howlader N, Horner MJ, Mariotto A, Miller BA, Feuer EJ, Altekruse SF, Lewis DR, Clegg L et al. (2008) SEER cancer statistics review, 1975–2005, , based on November 2007 SEER data submission, posted to the SEER web site. National Cancer Institute, Bethesda, MD
  7. 7.
    Karim-Kos HE, Vars E, Soerjomataram I, Lemmens V, Siesling S, Coebergh JW (2008) Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer 44:1345–1389PubMedCrossRefGoogle Scholar
  8. 8.
    Richards M (2007) EUROCARE-4 studies bring new data on cancer survival. Lancet Oncol 8(9):752–753PubMedCrossRefGoogle Scholar
  9. 9.
    Sankaranarayanan R, Black RJ, Swaminathan R, Parkin DM (1998) An overview of Cancer Survival in developing countries. In Sankaranarayanan R, Black RJ, Parkin DM (eds) Cancer Survival in Developing Countries IARC Scientific Publications No 145. IARC, Lyon, pp. 135–173Google Scholar
  10. 10.
    WHO (1996) Mortality database. World Health OrganizationGoogle Scholar
  11. 11.
    Bray I, Brennan P, Boffetta P (2000) Projections of alcohol- and tobacco-related cancer mortality in Central Europe. Int J Cancer 87(1):122–128PubMedCrossRefGoogle Scholar
  12. 12.
    Lambda SA, Ferlay J, Bray F, Parkin DM (2001) European Network of Cancer Registries. EUROCIM, version 4.0. European database V2.4 (2003), LyonGoogle Scholar
  13. 13.
    Capocaccia R, Gatta G, Roazzi P, Carrani E, Santaquilani M, De Angelis R, Tavilla A (2003) The EUROCARE-3 database: methodology of data collection, standardisation, quality control and statistical analysis. Ann Oncol 14(suppl. 5):v14–v27PubMedCrossRefGoogle Scholar
  14. 14.
    Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, Bernstein L, Schoenberg JB, Stemhagen A, Fraumeni JF Jr (1988) Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 48(11):3282–3287PubMedGoogle Scholar
  15. 15.
    Negri E, La Vecchia C, Franceschi S, Tavani A (1993) Attributable risk for oral cancer in northern Italy. Cancer Epidemiol Biomarkers Prev 2(3):189–193PubMedGoogle Scholar
  16. 16.
    Balaram P, Sridhar H, Rajkumar T, Vaccarella S, Herrero R, Nandakumar A, Ravichandran K, Ramdas K, Sankaranarayanan R, Gajalakshmi V, Munoz N, Franceschi S (2002) Oral cancer in southern India: the influence of smoking, drinking, paan-chewing and oral hygiene. Int J Cancer 98(3):440–445PubMedCrossRefGoogle Scholar
  17. 17.
    Sankaranarayanan R, Ramadas K, Thomas G, Muwonge R, Thara S, Mathew B, Rajan B (2005) Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet 365(9475):1927–1933PubMedCrossRefGoogle Scholar
  18. 18.
    Marimo C, Hille JJ (2006) The burden of oral malignancies in Zimbabwe 1988 to 1997: a population based study. Cent Afr J Med. 52(5–6):51–5PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Mia Hashibe
    • 1
  • Jacques Ferlay
    • 2
  • Rengaswamy Sankaranarayanan
    • 3
  1. 1.Division of Public Health, Department of Family & Preventive MedicineUniversity of Utah School of MedicineSalt Lake City, Utah
  2. 2.Data Analysis and Interpretation Group, Section of Cancer InformationInternational Agency for Research on CancerLyonFrance
  3. 3.Screening Group, Section of Early Detection and PreventionInternational Agency for Research on CancerLyonFrance

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