Classification, Clinical Features, and Molecular Genetic Models

  • Wayne M. Koch
  • Melonie Nance


Squamous cell carcinoma of the upper aerodigestive tract (head and neck squamous cell carcinoma, HNSCC) is often considered to be a single disease based on the cell of origin (mucosal epithelium) and histologic features. However, distinctive phenotypic patterns and genotypic correlates increasingly suggest that it might be more accurately thought of as consisting of different entities. These observations have been evolving in the context of the more traditional paradigms of tumor classification based on well established parameters such as primary tumor anatomical site, stage, and histologic features. Taken together, clinicians seek to use new and traditional tumor features to categorize tumors, predict their potential clinical course, and select appropriate strategies for their detection and treatment.


Human Papilloma Virus Neck Dissection Neck Squamous Cell Carcinoma Oral Squamous Cell Carcinoma Lichen Planus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Wayne M. Koch
    • 1
  • Melonie Nance
    • 2
  1. 1.Department of Otolaryngology – Head and Neck SurgeryJohns Hopkins University 601NBaltimore, MD
  2. 2.Department of Otolaryngology – Head and Neck SurgeryIndiara UniversityIndiara

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