Advertisement

Principles of Cryoablation

  • Nicholas Kujala
  • Michael D. Beland
Chapter

Abstract

Cryoablation is a minimally invasive treatment option that utilizes cryogens to apply freezing temperatures and destroy target tissues. It may be used as a primary treatment for localized tumors or as a palliative therapy for large or painful tumors. Improvements in image guidance allowing for real-time monitoring and improvements in cryoablative equipment with enhanced freezing capacity and smaller diameter cryoapplicators are fostering the continued development of this well-tolerated treatment in many clinical settings.

Keywords

Electrical Impedance Tomography Giant Cell Tumor Ablation Zone High Intensity Focus Ultrasound High Intensity Focus Ultrasound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Baust JG, Gage AA, Robilotto AT, Baust JM. The pathophysiology of thermoablation: optimizing cryoablation. Curr Opin Urol. 2009;19(2):127–32.PubMedCrossRefGoogle Scholar
  2. 2.
    Cooper SM, Dawber RPR. The history of cryosurgery. JR Soc Med. 2001;94(4):196–201.Google Scholar
  3. 3.
    Beland MD, Dupuy DE, Mayo-Smith WW. Percutaneous cryoablation of symptomatic extraabdominal metastatic disease: preliminary results. AJR Am J Roentgenol. 2005;184:926–30.PubMedGoogle Scholar
  4. 4.
    Arnott J. On the treatment of cancer by the regulated application of an anaesthetic temperature. London: Churchill; 1851.Google Scholar
  5. 5.
    Cooper IS. Cryogenic surgery: a new method of deconstruction or extirpation of benign or malignant tissues. N Eng J Med. 1963;268:743–9.CrossRefGoogle Scholar
  6. 6.
    Gonder M, Sloanes W, Smith V. Experimental prostate cryosurgery. Invest Urol. 1964;1:610–9.PubMedGoogle Scholar
  7. 7.
    Bush IM, Santoni E, Lieberman PH, Cahan WG, Whitmore WF. Some effects of freezing the rat kidney in situ. Cryobiology. 1964;2:163–70.CrossRefGoogle Scholar
  8. 8.
    Gage AA. History of cryosurgery. Semin Surg Oncol. 1998;14:99–109.PubMedCrossRefGoogle Scholar
  9. 9.
    Gage AA, Baust JG. Cryosurgery for tumors. J Am Coll Surg. 2007;205(2):342–56.PubMedCrossRefGoogle Scholar
  10. 10.
    Baust JG, Gage AA. The molecular basis of cryosurgery. BJU Int. 2005;95:1187–91.PubMedCrossRefGoogle Scholar
  11. 11.
    Baust JG, Gage AA, Clarke D, Baust JM, Van Buskirk R. Cryosurgery – a putative approach to molecular-based optimization. Cryobiology. 2004;48:190–204.PubMedCrossRefGoogle Scholar
  12. 12.
    Carvalhal EF, Novick AC, Gill IS. Renal cryoablation application in nephron-sparing treatment. Braz J Urol. 2000;26:558–70.Google Scholar
  13. 13.
    Clarke D, Hollister WR, Baust JG, van Buskirk RG. Cryosurgical modeling: sequence of freezing and cytotoxic agent application affects cell death. Mol Urol. 1999;3:25–31.PubMedGoogle Scholar
  14. 14.
    Klossner DP, Clarke DM, VanBuskirk RG, et al. Cryosurgical technique: assessment of the fundamental variables using human prostate cancer model systems. Cryobiology. 2007;55:189–99.PubMedCrossRefGoogle Scholar
  15. 15.
    Gage AA, Baust JG. Mechanisms of tissue injury in cryosurgery. Cryobiology. 1998;37:171–86.PubMedCrossRefGoogle Scholar
  16. 16.
    Cohen J, Miller R, Shuman B. Urethral warming catheter for use during cryoablation of the prostate. Urology. 1995;45:861–4.PubMedCrossRefGoogle Scholar
  17. 17.
    Yang WL, Addona T, Nair DG, et al. Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. Int J Cancer. 2001;103:360–9.CrossRefGoogle Scholar
  18. 18.
    Campbell SC, Krishnamurthy V, Chow G, Hale J, Myles J, Novick AC. Renal cryosurgery; experimental evaluation of treatment parameters. Urology. 1998;52:29–34.PubMedCrossRefGoogle Scholar
  19. 19.
    Saliken JC, Cohen J, Miller R, et al. Laboratory evaluation of ice formation around a 3-mm accuprobe. Cryobiology. 1995;32:285–95.CrossRefGoogle Scholar
  20. 20.
    Hewitt PM, Zhao J, Akhter J, Morris DL. A comparative laboratory study of liquid nitrogen and argon gas cryosurgery systems. Cryobiology. 1997;35:303–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Baissalov R, Sandison GA, Donnelly BJ, et al. A semi-empirical treatment planning model for optimization of multiprobe cryosurgery. Phys Med Biol. 2000;45:1085–98.PubMedCrossRefGoogle Scholar
  22. 22.
    Baissalov R, Sandison GA, Reynolds D, Muldrew K. Simultaneous optimization of cryoprobe placement and thermal protocol for cryosurgery. Phys Med Biol. 2001;46:1799–814.PubMedCrossRefGoogle Scholar
  23. 23.
    Brewer WH, Austin RS, Capps G, Neifeld JP. Intraoperative monitoring and postoperative imaging of hepatic cryosurgery. Semin Surg Oncol. 1998;14:129–55.PubMedCrossRefGoogle Scholar
  24. 24.
    Silverman SG, Sun MR, Tuncali K, et al. Three-dimensional assessment of MRI-guided percutaneous cryotherapy of liver metastases. AJR Am J Roentgenol. 2004;183:707–12.PubMedGoogle Scholar
  25. 25.
    Silverman SG, Tuncali K, van Sonnenberg E, et al. Renal tumors: MR imaging-guided percutaneous cryotherapy–initial experience in 23 patients. Radiology. 2005;236:716–24.PubMedCrossRefGoogle Scholar
  26. 26.
    Tacke J, Speetzen R, Heschel I, et al. Imaging of interstitial cryotherapy – an in vitro comparison of ultrasound, computed tomography, and magnetic resonance imaging. Cryobiology. 1999;38:250–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Onik G, Cobb C, Cohen J, et al. US characteristics of frozen prostate. Radiology. 1988;168:629–31.PubMedGoogle Scholar
  28. 28.
    Anderson JK, Shingleton WB, Cadedda JA. Imaging associated with percutaneous and intraoperative management of renal tumors. Urol Clin North Am. 2006;33:339–52.PubMedCrossRefGoogle Scholar
  29. 29.
    Silverman SG, Tuncali K, Adams DF, et al. MR imaging-guided percutaneous cryotherapy of liver tumors: initial experience. Radiology. 2000;217:657–64.PubMedGoogle Scholar
  30. 30.
    Gupta A, Allaf ME, Kavoussi LR, et al. Computerized tomography guided percutaneous renal cryoablation with the patient under conscious sedation: initial clinical experience. J Urol. 2006;175:447–53.PubMedCrossRefGoogle Scholar
  31. 31.
    Permpongkosol S, Sulman A, Solomon SB, et al. Percutaneous computerized tomography guided renal cryoablation using local anesthesia: pain assessment. J Urol. 2006;176:915–8.PubMedCrossRefGoogle Scholar
  32. 32.
    Saliken JC, McKinnon JG, Gray R. CT for monitoring cryotherapy. AJR Am J Roentgenol. 1996;166:853–5.PubMedGoogle Scholar
  33. 33.
    McDannold NJ, Jolesz FA. Magnetic resonance image-guided thermal ablations. Top Magn Reson Imaging. 2000;11(3):191–202.PubMedCrossRefGoogle Scholar
  34. 34.
    Mala T, Samset E, Aurdal L, et al. Magnetic resonance imaging-estimated three-dimensional temperature distribution in liver cryolesions; a study of cryolesion characteristics assumed necessary for tumor ablation. Cryobiology. 2001;43:268–75.PubMedCrossRefGoogle Scholar
  35. 35.
    Harada J, Dohi M, Magnami T, et al. Initial experience of percutaneous renal cryosurgery under the guidance of a horizontal open MRI system. Radiat Med. 2001;19:291–6.PubMedGoogle Scholar
  36. 36.
    Mala T, Edwin B, Samset E, Gladhaug I, et al. Magnetic-resonance guided percutaneous cryoablation of hepatic tumours. Eur J Surg. 2001;167:610–7.PubMedCrossRefGoogle Scholar
  37. 37.
    Samset E, Mala T, Edwin B, et al. Validation of estimated 3D temperature maps during hepatic cryo surgery. Magn Reson Imaging. 2001;19:715–21.PubMedCrossRefGoogle Scholar
  38. 38.
    Mala T. Cryoablation of liver tumors – a review of mechanisms, techniques, and clinical outcome. Minim Invasive Ther Allied Technol. 2006;15:9–17.PubMedCrossRefGoogle Scholar
  39. 39.
    Seifert JK, Springer A, Baier P, Junginger T. Liver resection or cryotherapy for colorectal liver metastasis: a prospective case control study. Int J Colorectal Dis. 2005;20:507–20.PubMedCrossRefGoogle Scholar
  40. 40.
    Adam R, Hagopian EJ, Linhares M, et al. A comparison of percutaneous cryosurgery and percutaneous radiofrequency for unresectable hepatic malignancies. Arch Surg. 2002;137:1332–9. discussion 1340.PubMedCrossRefGoogle Scholar
  41. 41.
    Crews KA, Kuhn JA, McCarty TM, et al. Cryosurgical ablation of hepatic tumors. Am J Surg. 1997;174:614–7. discussion 617–8.PubMedCrossRefGoogle Scholar
  42. 42.
    Sarantou T, Bilchik A, Ramming K. Complications of hepatic cryosurgery. Semin Surg Oncol. 1998;14:156–62.PubMedCrossRefGoogle Scholar
  43. 43.
    Zhou XD, Tang ZY. Cryotherapy for primary liver cancer. Semin Surg Oncol. 1998;14:171–4.PubMedCrossRefGoogle Scholar
  44. 44.
    Permpongkosol S, Nielsen ME, Solomon SB. Percutaneous renal cryoablation. Urology. 2006;68:19–25.PubMedCrossRefGoogle Scholar
  45. 45.
    Rodriguez R, Chan DY, Bishoff JT, et al. Renal ablative cryosurgery in selected patients with peripheral renal masses. Urology. 2000;55:25–30.PubMedCrossRefGoogle Scholar
  46. 46.
    Hegarty NJ, Gill IS, Desai MM, et al. Probe-ablative nephron-sparing surgery: cryoablation versus radiofrequency ablation. Urology. 2006;68:7–13.PubMedCrossRefGoogle Scholar
  47. 47.
    Kaouk JH, Aron M, Rewcastle JC, Gill IS. Cryotherapy: clinical end points and their experimental foundations. Urology. 2006;68:38–44.PubMedCrossRefGoogle Scholar
  48. 48.
    Tuncali K, Morrison PR, Tatli S, et al. MRI-guided percutaneous cryoablation of renal tumors: use of external manual displacement of adjacent bowel loops. Eur J Radiol. 2006;59:198–202.PubMedCrossRefGoogle Scholar
  49. 49.
    Davol PE, Fulmer BR, Rukstalis DB. Long-term results of cryoablation for renal cancer and complex renal masses. Urology. 2006;68:2–6.PubMedCrossRefGoogle Scholar
  50. 50.
    Gill IS, Remer EM, Hasan WA, et al. Renal cryoablation: outcome at 3 years. J Urol. 2005;173:1903–7.PubMedCrossRefGoogle Scholar
  51. 51.
    Donnelly BJ, Saliken JC, Ernst DS, et al. Prospective trial of cryosurgical ablation of the prostate: five-year results. Urology. 2002;60:645–8.PubMedCrossRefGoogle Scholar
  52. 52.
    Bahn DK, Lee F, Badalament R, et al. Targeted cryoablation of the prostate: 7 year outcomes in the primary treatment of prostate cancer. Urology. 2002;60:3–11.PubMedCrossRefGoogle Scholar
  53. 53.
    Chin JL, Downey DB, Mulligan M, Fenster A. Three-dimensional transrectal ultrasound guided cryoablation for localized prostate cancer in nonsurgical candidates: a feasibility study and report of early results. J Urol. 1998;159:910–6.PubMedCrossRefGoogle Scholar
  54. 54.
    Cohen JK, Miller Jr RJ, Ahmed S, et al. Ten year biochemical disease control for prostate cancer patients treated with cryosurgery as primary therapy. Urology. 2008;71:515–8.PubMedCrossRefGoogle Scholar
  55. 55.
    Mouraviev V, Polascik TJ. Update on cryotherapy for prostate cancer in 2006. Curr Opin Urol. 2006;16:152–6.PubMedCrossRefGoogle Scholar
  56. 56.
    Veth R, Schreuder B, van Beem H, et al. Cryosurgery in aggressive, benign, and low-grade malignant bone tumours. Lancet Oncol. 2005;6:25–34.PubMedGoogle Scholar
  57. 57.
    Callstrom MR, Atwell TD, Charboneau JW, et al. Painful metastases involving bone: percutaneous image-guided cryoablation-prospective trial interim analysis. Radiology. 2006;241(2):572–80.PubMedCrossRefGoogle Scholar
  58. 58.
    Callstrom MR, Charboneau JW. Percutaneous ablation: safe, effective treatment of bone tumors. Oncology (Williston Park). 2005;19(11 Suppl 4):22–6.Google Scholar
  59. 59.
    Wang H, Littrup PJ, Duan Y, Zhang Y, Feng H, Nie Z. Thoracic masses treated with percutaneous cryotherapy: initial experience with more than 200 procedures. Radiology. 2005;235(1):289–98.PubMedCrossRefGoogle Scholar
  60. 60.
    Meijer S, de Rooij PD, Derksen EJ, et al. Cryosurgery for locally recurrent rectal cancer. Eur J Surg Oncol. 1992;18:255–7.PubMedGoogle Scholar
  61. 61.
    Davolos DM, Rubinsky B. Electrical impedence tomography of cell viability in tissue with application to cryosurgery. J Biomech Eng. 2004;126:305–9.CrossRefGoogle Scholar
  62. 62.
    Rossi MR, Tanaka D, Shimada K, Rabin Y. Computerized planning of prostate cryosurgery using variable cryoprobe insertion depth. Cryobiology. 2010;60:71–9.PubMedCrossRefGoogle Scholar
  63. 63.
    Yu TH, Liu J, Zhou YX. Selective freezing of target biological tissues after injection of solutions with specific thermal properties. Cryobiology. 2005;50:174–82.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Diagnostic ImagingRhode Island HospitalProvidenceUSA

Personalised recommendations