Skip to main content
SpringerLink
Log in

Nonradiological Treatment for Renal Tumors

  • Chapter
  • First Online:
Interventional Oncology

  • 1104 Accesses

Abstract

Traditionally, renal cell carcinoma (RCC) has been approached surgically via an open, flank approach with the goal of extirpation via nephrectomy. Recently, technical improvements stemming from a better understanding of the natural history of RCC have altered the approach to localized RCC, shifting treatment towards minimally invasive techniques and nephron-sparing surgery. Additionally, the benefit of cytoreductive surgery and metastasectomy has been realized in the era of antiangiogenic therapy for RCC. Herein, we review the most current trends in the surgical treatment of localized and metastatic RCC.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J Urol. 2006;176(6 Pt 1):2353–8.

    Article  PubMed  Google Scholar 

  2. Schwaibold HE, Stolzenburg JU. Laparoscopic partial nephrectomy. Arch Ital Urol Androl. 2009;81(2):72–5.

    PubMed  Google Scholar 

  3. Butler BP, Novick AC, Miller DP, Campbell SA, Licht MR. Management of small unilateral renal cell carcinomas: radical versus nephron-sparing surgery. Urology. 1995;45(1):34–40. discussion 40–1.

    Article  PubMed  CAS  Google Scholar 

  4. Steinbach F, Stockle M, Muller SC, et al. Conservative surgery of renal cell tumors in 140 patients: 21 years of experience. J Urol. 1992;148(1):24–9. discussion 29–30.

    PubMed  CAS  Google Scholar 

  5. Morgan WR, Zincke H. Progression and survival after renal-conserving surgery for renal cell carcinoma: experience in 104 patients and extended followup. J Urol. 1990;144(4):852–7. discussion 857–8.

    PubMed  CAS  Google Scholar 

  6. Patel MN, Krane LS, Bhandari A, et al. Robotic partial nephrectomy for renal tumors larger than 4 cm. Eur Urol. 2010;57(2):310–6.

    Article  PubMed  Google Scholar 

  7. Makhoul B, De La Taille A, Vordos D, et al. Laparoscopic radical nephrectomy for T1 renal cancer: the gold standard? A comparison of laparoscopic vs open nephrectomy. BJU Int. 2004;93(1):67–70.

    Article  PubMed  CAS  Google Scholar 

  8. Lane BR, Gill IS. 7-year oncological outcomes after laparoscopic and open partial nephrectomy. J Urol. 2010;183(2):473–9.

    Article  PubMed  Google Scholar 

  9. Licht MR, Novick AC, Goormastic M. Nephron sparing surgery in incidental versus suspected renal cell carcinoma. J Urol. 1994;152(1):39–42.

    PubMed  CAS  Google Scholar 

  10. Campbell SC, Novick AC, Belldegrun A, et al. Guideline for management of the clinical T1 renal mass. J Urol. 2009;182(4):1271–9.

    Article  PubMed  Google Scholar 

  11. Bird VG, Shields JM, Aziz M, Ayyathurai R, De Los Santos R, Roeter DH. Laparoscopic radical nephrectomy for patients with T2 and T3 renal-cell carcinoma: evaluation of perioperative outcomes. J Endourol. 2009;23(9):1527–33.

    Article  PubMed  Google Scholar 

  12. Gill IS, Kamoi K, Aron M, Desai MM. 800 laparoscopic partial nephrectomies: a single surgeon series. J Urol. 2010;183(1):34–41.

    Article  PubMed  Google Scholar 

  13. Flum AS, Wolf Jr JS. Laparoscopic partial nephrectomy for multiple ipsilateral renal tumors using a tailored surgical approach. J Endourol. 2010;24(4):557–61.

    Article  PubMed  Google Scholar 

  14. Clayman RV, Kavoussi LR, Figenshau RS, Chandhoke PS, Albala DM. Laparoscopic nephroureterectomy: initial clinical case report. J Laparoendosc Surg. 1991;1(6):343–9.

    Article  PubMed  CAS  Google Scholar 

  15. Luo JH, Zhou FJ, Xie D, et al. Analysis of long-term survival in patients with localized renal cell carcinoma: laparoscopic versus open radical nephrectomy. World J Urol. 2010;28(3):289–93.

    Article  PubMed  Google Scholar 

  16. Gill IS, Kavoussi LR, Lane BR, et al. Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol. 2007;178(1):41–6.

    Article  PubMed  Google Scholar 

  17. Novick AC. Laparoscopic and partial nephrectomy. Clin Cancer Res. 2004;10(18 Pt 2):6322S–7.

    Article  PubMed  Google Scholar 

  18. Ganpule AP, Sharma R, Thimmegowda M, Veeramani M, Desai MR. Laparoscopic radical nephrectomy versus open radical nephrectomy in T1-T3 renal tumors: an outcome analysis. Indian J Urol. 2008;24(1):39–43.

    Article  PubMed  Google Scholar 

  19. Breda A, Finelli A, Janetschek G, Porpiglia F, Montorsi F. Complications of laparoscopic surgery for renal masses: prevention, management, and comparison with the open experience. Eur Urol. 2009;55(4):836–50.

    Article  PubMed  Google Scholar 

  20. Dekernion JB, Ramming KP, Smith RB. The natural history of metastatic renal cell carcinoma: a computer analysis. J Urol. 1978;120(2):148–52.

    PubMed  CAS  Google Scholar 

  21. Mattar K, Finelli A. Expanding the indications for laparoscopic radical nephrectomy. Curr Opin Urol. 2007;17(2):88–92.

    Article  PubMed  Google Scholar 

  22. Sun M, Lughezzani G, Perrotte P, Karakiewicz PI. Treatment of metastatic renal cell carcinoma. Nat Rev Urol. 2010;7(6):327–38.

    Article  PubMed  CAS  Google Scholar 

  23. de Reijke TM, Bellmunt J, van Poppel H, Marreaud S, Aapro M. EORTC-GU group expert opinion on metastatic renal cell cancer. Eur J Cancer. 2009;45(5):765–73.

    Article  PubMed  Google Scholar 

  24. Flanigan RC, Mickisch G, Sylvester R, Tangen C, Van Poppel H, Crawford ED. Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol. 2004;171(3):1071–6.

    Article  PubMed  Google Scholar 

  25. Mickisch GH, Garin A, van Poppel H, de Prijck L, Sylvester R. European Organisation for Research and Treatment of Cancer (EORTC) Genitourinary Group. Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet. 2001;358(9286):966–70.

    Article  PubMed  CAS  Google Scholar 

  26. Flanigan RC, Salmon SE, Blumenstein BA, et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med. 2001;345(23):1655–9.

    Article  PubMed  CAS  Google Scholar 

  27. Campbell SC, Flanigan RC, Clark JI. Nephrectomy in metastatic renal cell carcinoma. Curr Treat Options Oncol. 2003;4(5):363–72.

    Article  PubMed  Google Scholar 

  28. Kutikov A, Uzzo RG, Caraway A, et al. Use of systemic therapy and factors affecting survival for patients undergoing cytoreductive nephrectomy. BJU Int. 2010;106(2):218–23.

    Article  PubMed  Google Scholar 

  29. Capitanio U, Jeldres C, Patard JJ, et al. Stage-specific effect of nodal metastases on survival in patients with non-metastatic renal cell carcinoma. BJU Int. 2009;103(1):33–7.

    Article  PubMed  Google Scholar 

  30. Leibovich BC, Blute ML. Lymph node dissection in the management of renal cell carcinoma. Urol Clin North Am. 2008;35(4):673–8. viii.

    Article  PubMed  Google Scholar 

  31. Blom JH, van Poppel H, Marechal JM, et al. Radical nephrectomy with and without lymph-node dissection: final results of European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881. Eur Urol. 2009;55(1):28–34.

    Article  PubMed  Google Scholar 

  32. Delacroix Jr SE, Wood CG. The role of lymphadenectomy in renal cell carcinoma. Curr Opin Urol. 2009;19(5):465–72.

    Article  PubMed  Google Scholar 

  33. Margulis V, Wood CG. The role of lymph node dissection in renal cell carcinoma: the pendulum swings back. Cancer J. 2008;14(5):308–14.

    Article  PubMed  Google Scholar 

  34. Wagner B, Patard JJ, Mejean A, et al. Prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma. Eur Urol. 2009;55(2):452–9.

    Article  PubMed  Google Scholar 

  35. Al Otaibi M, Youssif TA, Alkhaldi A, et al. Renal cell carcinoma with inferior vena caval extension: impact of tumour extent on surgical outcome. BJU Int. 2009;104(10):1467–70.

    Article  PubMed  Google Scholar 

  36. Sagalowsky AI, Kadesky KT, Ewalt DM, Kennedy TJ. Factors influencing adrenal metastasis in renal cell carcinoma. J Urol. 1994;151(5):1181–4.

    PubMed  CAS  Google Scholar 

  37. Kobayashi T, Nakamura E, Yamamoto S, et al. Low incidence of ipsilateral adrenal involvement and recurrences in patients with renal cell carcinoma undergoing radical nephrectomy: a retrospective analysis of 393 patients. Urology. 2003;62(1):40–5.

    Article  PubMed  Google Scholar 

  38. Pollak R, Prusak BF, Mozes MF. Anatomic abnormalities of cadaver kidneys procured for purposes of transplantation. Am Surg. 1986;52(5):233–5.

    PubMed  CAS  Google Scholar 

  39. Turkvatan A, Ozdemir M, Cumhur T, Olcer T. Multidetector CT angiography of renal vasculature: normal anatomy and variants. Eur Radiol. 2009;19(1):236–44.

    Article  PubMed  Google Scholar 

  40. Hernandez F, Ong AM, Rha KH, Pinto PA, Kavoussi LR. Laparoscopic renal surgery after spontaneous retroperitoneal hemorrhage. J Urol. 2003;170(3):749–51.

    Article  PubMed  Google Scholar 

  41. Becker F, Van Poppel H, Hakenberg OW, et al. Assessing the impact of ischaemia time during partial nephrectomy. Eur Urol. 2009;56(4):625–34.

    Article  PubMed  Google Scholar 

  42. Riggs SB, Larochelle JC, Belldegrun AS. Partial nephrectomy: a contemporary review regarding outcomes and different techniques. Cancer J. 2008;14(5):302–7.

    Article  PubMed  Google Scholar 

  43. McNeil BK, Flanigan RC. Complications of open renal surgery. In: Loughlin KR, editor. Complications of urologic surgery and practice: diagnosis, prevention, and management. New York, NY: Informa Healthcare USA; 2007. p. 65.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Massachusetts General Hospital, Boston, MA, USA

    Sarah P. Psutka & Brian H. Eisner

Authors
  1. Sarah P. Psutka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brian H. Eisner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sarah P. Psutka .

Editor information

Editors and Affiliations

  1. Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Fruit St. 55, Boston, 02114, Massachusetts, USA

    Peter Mueller

  2. Dept. Radiology, Guy’s and St. Thomas’ Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom

    Andreas Adam

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Psutka, S.P., Eisner, B.H. (2012). Nonradiological Treatment for Renal Tumors. In: Mueller, P., Adam, A. (eds) Interventional Oncology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1469-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-1469-9_11

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1468-2

  • Online ISBN: 978-1-4419-1469-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation