Electron Transfer as a Potential Cause of Diacetyl Toxicity in Popcorn Lung Disease
Bronchiolitis obliterans, a serious lung disease, arises in microwave popcorn plant workers who are exposed to butter-flavored volatiles, particularly diacetyl. Findings indicate that chronic inhalation of butter-flavoring volatiles compromises lung epithelial barrier function (Fedan et al. 2006).
KeywordsReactive Oxygen Species Electron Transfer Amyotrophic Lateral Sclerosis Electron Affinity Molecular Electrostatic Potential
Editorial assistance by Angelica Ruiz and Thelma Chavez is appreciated. ALC is partly supported through grant CHE-0719575 of the National Science Foundation.
- Berson A, Descatoire V, Sutton A, Fau D, Maulny B, Vadrot N, Feldmann G, Berthon B, Torkjmann T, Pessayre D (2001) Toxicity of alpidem, a peripheral benzodiazepine receptor ligand, but not zolpidem, in rat hepatocytes: Role of mitochondrial permeability transition and metabolic activation. J Pharmacol Exp Ther 299:793–800.Google Scholar
- Egilman D, Mailloux C, Valentin C (2007) Popcorn-worker lung caused by corporate and regulatory negligence: An avoidable tragedy. Int J Occup Environ Health 13:85–98.Google Scholar
- Halliwell B, Gutteridge JMC (1999) Free Radicals in Biology and Medicine, Oxford University Press, New York pp 1–897.Google Scholar
- Hanson DG (2009) OSHA withdraws diacetyl proposal. Chem Eng News 87:23.Google Scholar
- ILS (2007) Integrated Laboratory Systems Inc: Chemical Information Review Document for Artificial Butter Flavoring and Constituents Diacetyl [CAS No. 431-03-08] and Acetoin [CAS No. 513-86-0], http://ntp.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/Artificial_butter_flavoring.pdf 2007.
- Kovacic P, Jacintho JD (2001) Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer. Curr Med Chem 8:773–796.Google Scholar
- Kovacic P, Kassel MA, Popp WJ, Feinberg BA (1990) Mechanisms of antiviral action: Focus on electron transfer and oxidative stress. J Biopharmaceut Sci 1:315–330.Google Scholar
- Kovacic P, Somanathan R (2006b) In: New Research on Alcohol Abuse and Alcoholism. Brozner EY (ed), Nova Science, New York, pp 51–58.Google Scholar
- Kovacic P, Somanathan R (2009a) Zolipidem, a clinical hypnotic that affects electronic transfer, alters synaptic activity through potential GABA receptors in the nervous system without significant free radical generation. Oxid Med Cell Longev 2: 116–121.Google Scholar
- Kovacic P, Wakelin LPG (2001) DNA molecular electrostatic potential, novel perspectives for the mechanisms of action of anticancer drugs involving electron transfer and oxidative stress. Anti-Canc Drug Des 16:1–10.Google Scholar
- Mellado JMR, Montoya MR (1994b) Correlations between chemical reactivity and mutagenic activity against S. typhimurium mechanism TA100 for dicarbonyl compounds as proof of mutagenic mechanism. Mutat Res 304:261–264.Google Scholar
- Niufar NN, Haycock FL, Wesemann JL, MacStay JA, Heasley VL, Kovacic P (2002) Reduction potentials of conjugated aliphatic ketones, oximes and imines: Correlation with structure and bioactivity. Rev Chem Soc Mex 46:307–312.Google Scholar
- Otsuka M, Mine T, Ohuchi K, Ohmori S (1996) A detoxification route for acetaldehyde, metabolism of diacetyl, acetoin and 2,3-butanediol in liver homogenate perfused liver of rats. J Biochem (Tokyo) 119:246–251.Google Scholar
- Poli G, Cheeseman KH, Dianzani MU, Slater TF (1989) Free Radicals in the Pathogenesis of Liver Injury, Pergamon, New York, pp 1–330.Google Scholar
- Russell GA (1968) In: Radical Ions. Interscience. Kaiser ET, Kevan N (eds), New York, pp 91–106.Google Scholar
- Schlichter LC, Pahapill PA, Chung I (1992) Dual action of 2,3-bulanedione monoxime (BDM) on K+ currents in human T lymphocytes. J Pharmacol Exp Ther 261:438–446.Google Scholar
- Schneider A (2007) Seattle Post-Intelligencer, Dec: 21: p. A.1.Google Scholar
- Traverso N, Manini S, Cottalasso D, Odetti P, Marinari UM, Pronzato MA (1997) Mutual interaction between glycation and oxidation during non-enzymatic protein modification. Biochim Biophys Acta 1336:409–418.Google Scholar
- Walker GR, Feather MS (1983) The Maillard Reaction in Food and Nutrition, ACS Symposium Series. 215:ACS, Washington, DC, p 36.Google Scholar