A Role for eNOS in Oncogenic Ras-Driven Cancer

Part of the Cancer Drug Discovery and Development book series (CDD&D)


Nitric oxide (NO) is a highly diffusible gas that is generated by the family of nitric oxide synthases and is increasingly associated with tumorigenesis. While both pro- and anti-tumorigenic properties have been ascribed to NO signaling, recent evidence suggests that eNOS or endothelial nitric oxide synthase promotes tumor formation through its effects on proliferation, cell survival, and angiogenesis. In this chapter we discuss recent evidence that eNOS promotes tumorigenic growth through the activation of the Ras family of proteins.


Nitric oxide eNOS Tumorigenesis Pancreatic cancer Ras 


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© Springer Science + Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Pharmacology and Cancer Biology, Department of Radiation OncologyDuke University Medical CenterDurhamUSA

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