Genetics and Functional Pathology of Idiopathic Scoliosis

  • Nancy H. Miller


Idiopathic scoliosis is a fixed structural lateral curve of the spine of ≥10° affecting 2–3% of children making it the most common spinal abnormality in children. Clinically, it is characterized by a subtle, pain-free onset of bony deformity in otherwise normal individuals (see Fig. 8.1). Although the female-to-male ratio is approximately 1:1 for minor curves, the proportion of females increases dramatically as the curve magnitude increases for unknown reasons (Kane and Moe 1970). The wide variation of presentation, the limited therapeutic options, and the inability to detect individuals at risk for significant progression have led to the establishment of high-cost screening programs in the United States.


Adolescent Idiopathic Scoliosis Idiopathic Scoliosis Osteogenesis Imperfecta Curve Progression Early Onset Scoliosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We would like to thank Kandice Swindle, Shane Cook, Jeffrey Dunn for editorial assistance.


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Authors and Affiliations

  1. 1.Department of Orthopaedic Surgery, Musculoskeletal Research CenterThe Children’s Hospital and University of Colorado Denver, Anschutz Medical CampusAuroraUSA

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