Increased Expression of TGF-β1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice

  • Fan Yingchuan
  • Lei Chuntao
  • Chen Hui
  • Hu Jianbin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)


Retinal neovascularization (NV) is a major cause of the blindness associated with such ischemic retinal disorders as diabetic retinopathy, retinopathy of prematurity and retinal occlusion. Neovascularization is induced by complex interactions among growth factors and cytokines. Some studies confirm that VEGF play a central role in neovascularization, there remain some questions as to why VEGF antagonists are only partially effective. Transforming growth factor-β (TGF-β) has been implicated in the development of neovascularization (Gerard et al. 2000). Smad 4 plays the most important role in the TGF-β signal transduction (Zimowska 2006). In this study, we used the model of oxygen-induced retinopathy in neonatal mice to investigate the expression of TGF-β1 and Smad 4 mRNA in the retina, to explore their role in the development of retinal neovascularization.


Diabetic Retinopathy Retinal Neovascularization Single Endothelial Cell Vascular Tumor Growth Endothelial Cell Nucleus 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of OphthalmologySichuan Academy of Medical Sciences & Sichuan Provincial People’s HospitalSichuanChina
  2. 2.Department of OphthalmologySichuan Provincial People’s HospitalChengduChina

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