Correlation Between Tissue Docosahexaenoic Acid Levels and Susceptibility to Light-Induced Retinal Degeneration

  • Masaki Tanito
  • Richard S. Brush
  • Michael H. Elliott
  • Lea D. Wicker
  • Kimberly R. Henry
  • Robert E. Anderson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)


In a mouse model of acute light-induced retinal degeneration, positive correlations between the levels of DHA, the levels of n3 PUFA lipid peroxidation, and the vulnerability to photooxidative stress were observed. On the other hand, higher sensitivity of the electroretinogram a-wave response, a measure of the amplification of the phototransduction cascade, was correlated with higher retinal DHA levels. These results highlight the dual roles of DHA in cellular physiology and pathology.


Outer Nuclear Layer Photooxidative Stress Outer Nuclear Layer Thickness Polyunsaturated Fatty Acid Level Outer Nuclear Layer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Financial support from the Foundation Fighting Blindness, Research to Prevent Blindness, Inc., the National Eye Institute (EY12190, EY04149, and EY00871), and National Center for Research Resources (RR17703) is gratefully acknowledged.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Masaki Tanito
    • 1
  • Richard S. Brush
    • 2
    • 3
    • 4
  • Michael H. Elliott
    • 2
    • 4
  • Lea D. Wicker
    • 2
    • 3
  • Kimberly R. Henry
    • 2
    • 3
  • Robert E. Anderson
    • 5
    • 3
    • 4
  1. 1.Department of OphthalmologyShimane University Faculty of MedicineShimaneJapan
  2. 2.Department of OphthalmologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  3. 3.Dean A. McGee Eye InstituteOklahomaUSA
  4. 4.Department of Cell BiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  5. 5.Department of Cell Biology and OphthalmologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA

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