Correlation Between Tissue Docosahexaenoic Acid Levels and Susceptibility to Light-Induced Retinal Degeneration
In a mouse model of acute light-induced retinal degeneration, positive correlations between the levels of DHA, the levels of n3 PUFA lipid peroxidation, and the vulnerability to photooxidative stress were observed. On the other hand, higher sensitivity of the electroretinogram a-wave response, a measure of the amplification of the phototransduction cascade, was correlated with higher retinal DHA levels. These results highlight the dual roles of DHA in cellular physiology and pathology.
KeywordsOuter Nuclear Layer Photooxidative Stress Outer Nuclear Layer Thickness Polyunsaturated Fatty Acid Level Outer Nuclear Layer Cell
Financial support from the Foundation Fighting Blindness, Research to Prevent Blindness, Inc., the National Eye Institute (EY12190, EY04149, and EY00871), and National Center for Research Resources (RR17703) is gratefully acknowledged.
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