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Correlation Between Tissue Docosahexaenoic Acid Levels and Susceptibility to Light-Induced Retinal Degeneration

  • Masaki Tanito
  • Richard S. Brush
  • Michael H. Elliott
  • Lea D. Wicker
  • Kimberly R. Henry
  • Robert E. Anderson
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)

Abstract

In a mouse model of acute light-induced retinal degeneration, positive correlations between the levels of DHA, the levels of n3 PUFA lipid peroxidation, and the vulnerability to photooxidative stress were observed. On the other hand, higher sensitivity of the electroretinogram a-wave response, a measure of the amplification of the phototransduction cascade, was correlated with higher retinal DHA levels. These results highlight the dual roles of DHA in cellular physiology and pathology.

Keywords

Outer Nuclear Layer Photooxidative Stress Outer Nuclear Layer Thickness Polyunsaturated Fatty Acid Level Outer Nuclear Layer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Financial support from the Foundation Fighting Blindness, Research to Prevent Blindness, Inc., the National Eye Institute (EY12190, EY04149, and EY00871), and National Center for Research Resources (RR17703) is gratefully acknowledged.

References

  1. Anderson RE, Penn JS (2004) Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function. Lipids 39:1121–1124CrossRefPubMedGoogle Scholar
  2. Awasthi YC, Yang Y, Tiwari NK et al (2004) Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radic Biol Med 37:607–619CrossRefPubMedGoogle Scholar
  3. Benolken RM, Anderson RE, Wheeler TG (1973) Membrane fatty acids associated with the electrical response in visual excitation. Science 182:1253–1254CrossRefPubMedGoogle Scholar
  4. Birch DG, Birch EE, Hoffman DR et al (1992) Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids. Invest Ophthalmol Vis Sci 33:2365–2376PubMedGoogle Scholar
  5. Bush RA, Reme CE, Malnoe A (1991) Light damage in the rat retina: the effect of dietary deprivation of N-3 fatty acids on acute structural alterations. Exp Eye Res 53:741–752CrossRefPubMedGoogle Scholar
  6. Bush RA, Malnoe A, Reme CE et al (1994) Dietary deficiency of N-3 fatty acids alters rhodopsin content and function in the rat retina. Invest Ophthalmol Vis Sci 35:91–100PubMedGoogle Scholar
  7. De La Paz MA, Anderson RE (1992) Lipid peroxidation in rod outer segments. Role of hydroxyl radical and lipid hydroperoxides. Invest Ophthalmol Vis Sci 33:2091–2096Google Scholar
  8. Fliesler SJ, Anderson RE (1983) Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipid Res 22:79–131CrossRefPubMedGoogle Scholar
  9. Jeffrey BG, Mitchell DC, Gibson RA et al (2002) n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. Invest Ophthalmol Vis Sci 43:2806–2814PubMedGoogle Scholar
  10. Kang JX, Wang J, Wu L et al (2004) Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature 427:504CrossRefPubMedGoogle Scholar
  11. Koutz CA, Wiegand RD, Rapp LM et al (1995) Effect of dietary fat on the response of the rat retina to chronic and acute light stress. Exp Eye Res 60:307–316CrossRefPubMedGoogle Scholar
  12. Mitchell DC, Niu SL, Litman BJ (2003) Enhancement of G protein-coupled signaling by DHA phospholipids. Lipids 38:437–443CrossRefPubMedGoogle Scholar
  13. Morrison WR, Smith LM (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol. J Lipid Res 5:600–608PubMedGoogle Scholar
  14. Niu SL, Mitchell DC, Lim SY et al (2004) Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. J Biol Chem 279:31098–31104CrossRefPubMedGoogle Scholar
  15. Organisciak DT, Darrow RM, Jiang YL et al (1996) Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. Invest Ophthalmol Vis Sci 37:2243–2257PubMedGoogle Scholar
  16. Organisciak DT, Darrow RM, Jiang YI et al (1992) Protection by dimethylthiourea against retinal light damage in rats. Invest Ophthalmol Vis Sci 33:1599–1609PubMedGoogle Scholar
  17. Spychalla JP, Kinney AJ, Browse J (1997) Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis. Proc Natl Acad Sci U S A 94:1142–1147CrossRefPubMedGoogle Scholar
  18. Tanito M, Anderson RE (2006) Bright cyclic light rearing-mediated retinal protection against damaging light exposure in adrenalectomized mice. Exp Eye Res 83:697–701CrossRefPubMedGoogle Scholar
  19. Tanito M, Kaidzu S, Anderson RE (2007) Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats. Invest Ophthalmol Vis Sci 48:1864–1872CrossRefPubMedGoogle Scholar
  20. Tanito M, Elliott MH, Kotake Y et al (2005) Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci 46:3859–3868CrossRefPubMedGoogle Scholar
  21. Tanito M, Yoshida Y, Kaidzu S et al (2006a) Detection of lipid peroxidation in light-exposed mouse retina assessed by oxidative stress markers, total hydroxyoctadecadienoic acid and 8-iso-prostaglandin F(2alpha). Neurosci Lett 398:63–68CrossRefPubMedGoogle Scholar
  22. Tanito M, Brush RS, Elliott MH et al (2009) High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res 50(5):807–819Google Scholar
  23. Tanito M, Haniu H, Elliott MH et al (2006b) Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. Free Radic Biol Med 41:1847–1859CrossRefPubMedGoogle Scholar
  24. Toyokuni S (1999) Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49:91–102CrossRefPubMedGoogle Scholar
  25. Tytell M, Barbe MF, Gower DJ (1989) Photoreceptor protection from light damage by hyperthermia. Prog Clin Biol Res 314:523–538PubMedGoogle Scholar
  26. Uchida K, Stadtman ER (1992) Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc Natl Acad Sci U S A 89:4544–4548CrossRefPubMedGoogle Scholar
  27. Wheeler TG, Benolken RM, Anderson RE (1975) Visual membranes: specificity of fatty acid precursors for the electrical response to illumination. Science 188:1312–1314CrossRefPubMedGoogle Scholar
  28. Wiegand RD, Giusto NM, Rapp LM et al (1983) Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Invest Ophthalmol Vis Sci 24:1433–1435PubMedGoogle Scholar
  29. Wiegand RD, Koutz CA, Stinson AM et al (1991) Conservation of docosahexaenoic acid in rod outer segments of rat retina during n-3 and n-6 fatty acid deficiency. J Neurochem 57:1690–1699CrossRefPubMedGoogle Scholar
  30. Winkler BS, Boulton ME, Gottsch JD et al (1999) Oxidative damage and age-related macular degeneration. Mol Vis 5:32PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Masaki Tanito
    • 1
  • Richard S. Brush
    • 2
    • 3
    • 4
  • Michael H. Elliott
    • 2
    • 4
  • Lea D. Wicker
    • 2
    • 3
  • Kimberly R. Henry
    • 2
    • 3
  • Robert E. Anderson
    • 5
    • 3
    • 4
  1. 1.Department of OphthalmologyShimane University Faculty of MedicineShimaneJapan
  2. 2.Department of OphthalmologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  3. 3.Dean A. McGee Eye InstituteOklahomaUSA
  4. 4.Department of Cell BiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  5. 5.Department of Cell Biology and OphthalmologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA

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